Molecular and Cellular Aspects of Muscle Contraction


This volume presents the proceedings of a muscle symposium, which was held as the Fourth Fujihara seminar on October 28 - November 1, 2002, at Hakone, Japan. This volume covers all fields of muscle biology, from molecules to humans. This book provides information about recent progress of muscle research as well as the problems that remain to be investigated. This volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle...

See more details below
Paperback (Softcover reprint of the original 1st ed. 2003)
$99.00 price
Other sellers (Paperback)
  • All (6) from $71.87   
  • New (5) from $71.87   
  • Used (1) from $141.00   
Sending request ...


This volume presents the proceedings of a muscle symposium, which was held as the Fourth Fujihara seminar on October 28 - November 1, 2002, at Hakone, Japan. This volume covers all fields of muscle biology, from molecules to humans. This book provides information about recent progress of muscle research as well as the problems that remain to be investigated. This volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle contraction.

Read More Show Less

Product Details

  • ISBN-13: 9781461347644
  • Publisher: Springer US
  • Publication date: 12/31/2013
  • Series: Advances in Experimental Medicine and Biology Series, #538
  • Edition description: Softcover reprint of the original 1st ed. 2003
  • Pages: 701
  • Product dimensions: 7.00 (w) x 10.00 (h) x 1.44 (d)

Table of Contents

Myosin Light Chain Composition in Non-Failing Donor and End-Stage Failing Human Ventricular Myocardium 3
Study of the Vertebrate MHC Multigene Family during Heart Development 17
Myosin-binding Protein C (MYBP-C) in Cardiac Muscle and Contractility 31
The Endocardial Endothelial Na[superscript +]/K[superscript +] ATPase and Cardiac Contraction 43
KLF5/BTEB2, a Kruppel-like Zinc-finger Type Transcription Factor, Mediates both Smooth Muscle Cell Activation and Cardiac Hypertrophy 57
Regulation of the Rho Signaling Pathway by Excitatory Agonists in Vascular Smooth Muscle 67
Human Heart Failure: Dilated Versus Familial Hypertrophic Cardiomyopathy 77
Regulation of Smooth Muscle Contraction by Calcium, Monomeric GTPases of the Rho Subfamily, and their Effector Kinases 89
Bio-nanomuscle Project: Contractile Properties of Single Actin Filaments in an A-band Motility Assay System 103
Development of an Apparatus to Control Load by Electromagnet for a Motility System In Vitro 111
High-Resolution Imaging of Myosin Motor in Action by a High-Speed Atomic Force Microscope 119
Translation Step Size Measured in Single Sarcomeres and Single Filament Pairs 129
Motor Function of Unconventional Myosin 143
Switch 1 Opens on Strong Binding to Action 159
Gene Transfer of Troponin I Isoforms, Mutants and Chimeras 169
A Hypothesis about Myosin Catalysis 175
In Vitro Actomyosin Motility in Deuterium Oxide 183
NMR Structural Study of Troponin C C-terminal Domain Complexed with Troponin I Fragment from Akazara Scallop 195
Calcium Binding to Troponin C as a Primary Step of the Regulation of Contraction 203
Isolation and Characterization of 190K Protein from Aorta Smooth Muscle 215
Several Aspects of Calcium Regulator, Mechanisms Linked to Troponin 221
X-ray Interference Evidence Concerning the Range of Cross-Bridge Movement, and Backbone Contributions to the Meridional Pattern 233
Modeling Analysis of Myosin-Based Meridional X-ray Reflections from Frog Skeletal Muscles in Relaxed and Contracting States 243
Myosin Filament Structure and Myosin Cross-bridge Dynamics in Fish and Insect Muscles 251
Use of Sinusoidal Length Oscillations to Detect Myosin Conformation by Time-Resolved X-ray Diffraction 267
Orientation and Motion of Myosin Light Chain and Troponin in Reconstituted Muscle Fibers as Detected by ESR with a New Bifunctional Spin-Label 279
Molecular Organizations of Myofibrils of Skeletal Muscle Studied by Atomic Force Microscopy 285
Three-dimensional Structural Analysis of Individual Myosin Heads under Various Functional States 295
Helical Order in Myosin Filaments and Evidence for One Ligand Inducing Multiple Myosin Conformations 305
Evidence for the Involvement of Myosin Subfragment 2 in Muscle Contraction 317
A Study of Lamellipodial Membrane Dynamics by Optical Trapping Technique: Implication of Motor Activity in Movements 335
Actin Dynamics in Neuronal Growth Cone Revealed with a Polarized Light Microscopy 347
Thermodynamic Mechano-Chemistry of Single Motor Enzymes 361
Cooperative Activation of Skeletal and Cardiac Muscle 371
Measurement of Force Developed by a Single Cardiac Myocyte Using Novel Carbon Fibers 381
The Special Structure and Function of Troponin I in Regulation of Cardiac Contraction and Relaxation 389
Pharmacological Calcium Sensitivity Modulation of Cardiac Myofilaments 403
20-Hydroxyeicosatetraenoic Acid Potentiates Contractile Activation of Canine Basilar Artery in Response to Stretch via Protein Kinase C[alpha]-Mediated Inhibition of Calcium-Activated Potassium Channel 411
Distinct Contractile Systems for Electromechanical and Pharmacomechanical Coupling in Smooth Muscle 417
Force Response to Stretches in Activated Frog Muscle Fibres at Low Tension 429
Molecular Step(s) of Force Generation: Temperature-Perturbation Experiments on Muscle Fibres 441
Rates of Force Generation in Drosophila Fast and Slow Muscle Types Have Opposite Responses to Phosphate 459
Does Cross-Bridge Activation Determine the Time Course of Myofibrillar Relaxation? 469
Inter-Sarcomere Dynamics in Muscle Fibres. A Negrected Subject? 481
Stretch-induced Force Enhancement and Stability of Skeletal Muscle Myofibrils 501
Adaptations in Titin's Spring Elements in Normal and Cardiomyopathic Hearts 517
An X-ray Diffraction Study on Contraction of Rat Papillary Muscle with Different Afterloads
Role of the T-system and the Na-K Pump on Fatigue Development in Phasic Skeletal Muscle 543
Mitochondrial Ca[superscript 2+] in Mouse Soleus Single Muscle Fibres in Response to Repeated Tetanic Contractions 557
Cellular Mechanisms of Skeletal Muscle Fatigue 563
Myofibrillar Determinants of Rate of Relaxation in Skinned Skeletal Muscle Fibers 573
Force, Sarcomere Shortening Velocity and ATPase Activity 583
Evidence for the High Mechanical Efficiency of Cross-Bridge Powerstroke in Skeletal Muscle 603
Rate of Actomyosin ATP Hydrolysis Diminishes during Isometric Contraction 613
Energy Storage during Stretch of Active Single Fibres 627
Three Dimensional Ultrasound Analysis of Fascicle Orientation in Human Tibialis Anterior Muscle Enables Analysis of Macroscopic Torque at the Cellular Level 635
General Discussion Part I 647
Special Talk: The Beginning of Low-Angle X-ray Diffraction Work on Living Muscles 655
General Discussion Part II 661
General Discussion Part III 671
Concluding Remarks: Progress in Determining the Detailed Mechanism of Muscle Contraction 683
Participants Photos 689
Participants 693
Subject Index 699
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)