Molecular and Cellular Glycobiology / Edition 2

Molecular and Cellular Glycobiology / Edition 2

by Minoru Fukuda, Ole Hindsgual
     
 

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ISBN-10: 0199638063

ISBN-13: 9780199638062

Pub. Date: 11/28/2000

Publisher: Oxford University Press, USA

This book covers the recent progress in understanding the biological roles of carbohydrates and includes basic knowledge of carbohydrates in mammals. Emphasis in on structure, biosynthesis and function of carbohydrates in development and disease, in particular, biological significance in immune cells, neural cells and cytoplasmic and nuclear proteins. It also

Overview

This book covers the recent progress in understanding the biological roles of carbohydrates and includes basic knowledge of carbohydrates in mammals. Emphasis in on structure, biosynthesis and function of carbohydrates in development and disease, in particular, biological significance in immune cells, neural cells and cytoplasmic and nuclear proteins. It also updates the knowledge of diseases caused by anomalies of carbohydrate biosynthesis and the animal models used to investigate the physiological roles of carbohydrates including carbohydrates attached to lipids and attempts to develop therapeutic agents based on carbohydrates.

Product Details

ISBN-13:
9780199638062
Publisher:
Oxford University Press, USA
Publication date:
11/28/2000
Series:
Frontiers in Molecular Biology Series, #30
Edition description:
REV
Pages:
316
Product dimensions:
7.10(w) x 9.30(h) x 0.50(d)

Table of Contents

List of contributors
Abbreviations
1. Cell surface carbohydrates: cell type-specific expression, Minoru Fukuda
1. Introduction
2. Structure of N-glycans
3. Cell type-specific expression of N-glycans
4. O-glycans
5. Roles of cell surface carbohydrates
6. Glycobiology—new frontiers in cell and molecular biology
Acknowledgements
References
2. Carbohydrate recognition in leukocyte-endothelial cell interactions, Jonathon W. Homeister and John B. Lowe
1. Introduction
2. Oligosaccharides in lymphocyte homing
3. Oligosaccharide-dependent cell adhesion mediated by E-selectin
4. Oligosaccharide-dependent cell adhesion mediated by P-selectin
5. The sequential, multi-molecule model for leukocyte rolling, adhesion and transmigration
Acknowledgements
References
3. Polysialic acid in neural cell development: roles, regulation and mechanism, Juan L. Brusés and Urs Rutishauser
1. Introduction
2. Biological roles of PSA
3. Regulation of PSA expression
4. Mechanisms of PSA action
5. Epilogue: the phylogeny of PSA-NCAM
References
4. Diseases with deficiencies in asparagine-linked glycosylation
A. Carbohydrate-deficient glycoprotein syndromes, Harry Schachter
1. Introduction
2. Carbohydrate-deficient glycoprotein syndrome type I
3. Complex N-glycan synthesis within the Golgi apparatus
4. Carbohydrate-deficient glycoprotein syndrome tupe II (CDGII)
Acknowledgements
References
B. Congenital dyserythropoietic anemia tupe II, Michiko N. Fukuda
1. Introduction
2. Incidence and symptoms of HEMPAS
3. Biochemical characteristics of HEMPAS
4. Genetic analysis of HEMPAS
5. An animal model of HEMPAS
6. Why does a glycosylation defect result in anemia?
7. Unsolved problems
Acknowledgements
References
5. Functions of carbohydrates revealed by transgenic technology, Pamela Stanley
1. Introduction
2. The first mouse glycosylation mutants
3. Insights from transgenic mice that misexpress or overexpress a glycosyltransferase
4. Insights from mice with targeted gene mutations
5. Considerations for the next generation of mouse glycosylation mutants
6. Challenges for the new millennium
Acknowledgements
References
6. Functional significance of O-GlcNAc glycoproteins in the nucleus and cytoplasm, Lisa K. Kreppel and Gerald W. Hart
1. Introduction
2. Dynamic O-GlcNAcylation of proteins
3. Nuclear O-GlcNAcylation
4. Cytoplasmic O-GlcNAcylation
5. Conclusion
References
7. Roles of sphingolipids and glycosphingolipids in biological membranes, Yoshio Hirabayashi and Shinichi Ichikawa
1. Introduction
2. General features of membrane sphingolipids
3. Metabolism of complex sphingolipids
4. Roles of sphingolipids revealed by studies of mutant cells
5. Studies of sphingolipid function at the whole-animal level
6. Conclusion
References
8. Carbohydrates in medicine, Joseph C. McAuliffe and Ole Hindsgaul
1. Introduction
2. Why carbohydrates?
3. Targets of carbohydrate therapeutics
4. Examples of carbohydrate-based drugs
5. Examples of carbohydrate-modified drugs
6. Examples of carbohydrates in drug delivery
7. Conclusion
Acknowledgements
References
Index

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