Molecular and Cellular Glycobiology / Edition 2

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Overview

"Glycobiology is now taking a central role in our understanding of cell function. This book is a comprehensive update of recent progress in the area, with emphasis on the structure, biosynthesis and function of carbohydrates in development and disease. Topics covered include: cell-type specific expression of cell surface carbohydrates, the roles of cell surface carbohydrates in leukocyte-endothelium interaction, O-GlcNAc glycoproteins in the nucleus and cytoplasm, the roles of sphingolipids and glycosphingolipids in membranes, and transgenic approaches to the analysis of carbohydrate function." "Molecular and Cellular Glycobiology also describes in detail our current knowledge of diseases caused by anomalies of carbohydrate biosynthesis and approaches to develop therapeutic agents based on carbohydrates." "Molecular and Cellular Glycobiology covers recent developments in this important field in a comprehensive yet focused manner. It will be of major interest to all researchers who study carbohydrates or biological molecules modified by glycosylation."--BOOK JACKET.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: The field of glycobiology has lagged somewhat behind that of protein and nucleic acid biology primarily because of the technical difficulties associated with saccharide chemistry.
Purpose: This volume highlights several recent developments in the area and can serve as an introduction to current work. The focus is on the role of glycoconjugates in recognition, regulation, and development.
Audience: Investigators interested in the areas discussed will find authoritative reviews with helpful bibliographies.
Features: The first chapter reviews the structures of N- and O-linked glycans. This is followed by sections on the function of cell surface carbohydrates in recognition and development. A discussion of deficiency diseases reviews recent work on specific enzymatic defects that lead to incompletely glycosylated proteins. A chapter on transgenic animals reviews what is currently known about knockouts. There is a short discussion of the role of some glycolipids, cytosolic O-glycosylation, and a recap of potential saccharide based drugs.
Assessment: The volume makes no attempt to be comprehensive and does not discuss recent work on proteoglycans or studies on the conformational effects of saccharide substitution on proteins. Those interested in the role of these molecules in plants will turn elsewhere.
Eugene A. Davidson
The field of glycobiology has lagged somewhat behind that of protein and nucleic acid biology primarily because of the technical difficulties associated with saccharide chemistry. This volume highlights several recent developments in the area and can serve as an introduction to current work. The focus is on the role of glycoconjugates in recognition, regulation, and development. Investigators interested in the areas discussed will find authoritative reviews with helpful bibliographies. The first chapter reviews the structures of N- and O-linked glycans. This is followed by sections on the function of cell surface carbohydrates in recognition and development. A discussion of deficiency diseases reviews recent work on specific enzymatic defects that lead to incompletely glycosylated proteins. A chapter on transgenic animals reviews what is currently known about knockouts. There is a short discussion of the role of some glycolipids, cytosolic O-glycosylation, and a recap of potential saccharide based drugs. The volume makes no attempt to be comprehensive and does not discuss recent work on proteoglycans or studies on the conformational effects of saccharide substitution on proteins. Those interested in the role of these molecules in plants will turn elsewhere.
Booknews
Provides an update of recent progress in the area of glycobiology, emphasizing the structure, biosynthesis, and function of carbohydrates in development and disease. Topics covered include cell-type specific expression of cell surface carbohydrates, the roles of cell surface carbohydrates in leukocyte-endothelium interaction, O-GlcNAc glycoproteins in the nucleus and cytoplasm, the roles of sphingolipids and glycosphingolipids in membranes, and transgenic approaches to the analysis of carbohydrate function. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780199638062
  • Publisher: Oxford University Press, USA
  • Publication date: 9/28/1999
  • Series: Frontiers in Molecular Biology Series , #30
  • Edition description: REV
  • Edition number: 2
  • Pages: 316
  • Product dimensions: 7.10 (w) x 9.30 (h) x 0.50 (d)

Table of Contents

List of contributors Abbreviations
1. Cell surface carbohydrates: cell type-specific expression, Minoru Fukuda
1. Introduction
2. Structure of N-glycans
3. Cell type-specific expression of N-glycans
4. O-glycans
5. Roles of cell surface carbohydrates
6. Glycobiology--new frontiers in cell and molecular biology Acknowledgements References
2. Carbohydrate recognition in leukocyte-endothelial cell interactions, Jonathon W. Homeister and John B. Lowe
1. Introduction
2. Oligosaccharides in lymphocyte homing
3. Oligosaccharide-dependent cell adhesion mediated by E-selectin
4. Oligosaccharide-dependent cell adhesion mediated by P-selectin
5. The sequential, multi-molecule model for leukocyte rolling, adhesion and transmigration Acknowledgements References
3. Polysialic acid in neural cell development: roles, regulation and mechanism, Juan L. Brus├ęs and Urs Rutishauser
1. Introduction
2. Biological roles of PSA
3. Regulation of PSA expression
4. Mechanisms of PSA action
5. Epilogue: the phylogeny of PSA-NCAM References
4. Diseases with deficiencies in asparagine-linked glycosylation
A. Carbohydrate-deficient glycoprotein syndromes, Harry Schachter
1. Introduction
2. Carbohydrate-deficient glycoprotein syndrome type I
3. Complex N-glycan synthesis within the Golgi apparatus
4. Carbohydrate-deficient glycoprotein syndrome tupe II (CDGII)
Acknowledgements References
B. Congenital dyserythropoietic anemia tupe II, Michiko N. Fukuda
1. Introduction
2. Incidence and symptoms of HEMPAS
3. Biochemical characteristics of HEMPAS
4. Genetic analysis of HEMPAS
5. An animal model of HEMPAS
6. Why does a glycosylation defect result in anemia?
7. Unsolved problems Acknowledgements References
5. Functions of carbohydrates revealed by transgenic technology, Pamela Stanley
1. Introduction
2. The first mouse glycosylation mutants
3. Insights from transgenic mice that misexpress or overexpress a glycosyltransferase
4. Insights from mice with targeted gene mutations
5. Considerations for the next generation of mouse glycosylation mutants
6. Challenges for the new millennium Acknowledgements References
6. Functional significance of O-GlcNAc glycoproteins in the nucleus and cytoplasm, Lisa K. Kreppel and Gerald W. Hart
1. Introduction
2. Dynamic O-GlcNAcylation of proteins
3. Nuclear O-GlcNAcylation
4. Cytoplasmic O-GlcNAcylation
5. Conclusion References
7. Roles of sphingolipids and glycosphingolipids in biological membranes, Yoshio Hirabayashi and Shinichi Ichikawa
1. Introduction
2. General features of membrane sphingolipids
3. Metabolism of complex sphingolipids
4. Roles of sphingolipids revealed by studies of mutant cells
5. Studies of sphingolipid function at the whole-animal level
6. Conclusion References
8. Carbohydrates in medicine, Joseph C. McAuliffe and Ole Hindsgaul
1. Introduction
2. Why carbohydrates?
3. Targets of carbohydrate therapeutics
4. Examples of carbohydrate-based drugs
5. Examples of carbohydrate-modified drugs
6. Examples of carbohydrates in drug delivery
7. Conclusion Acknowledgements References
Index

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