Molecular Assembly of Biomimetic Systems / Edition 1by Junbai Li, Qiang He, Xuehai Yan
In nature, biological systems and physiological processes have evolved over millions of years to improve their properties and functions. Biomimetics is the study and use of the structured and function of living things to create materials or products by reverse engineering. A major advantage of these systems is that both biochemical and physical parameters can be… See more details below
In nature, biological systems and physiological processes have evolved over millions of years to improve their properties and functions. Biomimetics is the study and use of the structured and function of living things to create materials or products by reverse engineering. A major advantage of these systems is that both biochemical and physical parameters can be precisely controlled, therefore enabling the utilization of biomimetic systems experimental model s for guiding the research on the biological mutation and evolution in the organisms. Some bioactive molecular such as peptides, proteins, nucleic acids and lipids can undergo self-assembly into well defined structures similar to the assembly in living organs. Biomimetrics is not limited to just copying nature because with the development of modern biology, scientists can direct utilize biological units themselves to construct new types of systems sometimes as hybrid nanostructured materials. This book covers fundamental aspects and practical techniques of molecular assembly of biomimetic systems, especially, the layer-by-layer assembly, self-assembly, microcontact printing, electron beam lithography and chemical nanolithography. Aimed at graduate students as well as researchers carrying out research and development in nanotechnology, biotechnology and materials sciences.
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Table of Contents
Layer-by-Layer Assembly of Biomimetic Microcapsules.
FoF1-ATP Synthase-Based Active Biomimetic Systems.
Kinesin–Microtubule-Driven Active Biomimetic Systems.
Peptide-Based Biomimetic Materials.
1 Biomimetic Membranes.
1.2 Lipid Monolayers.
1.2.1 Phospholipid Monolayers at the Air/Water Interface.
1.2.2 Phospholipid Monolayers at the Oil/Water Interface.
1.2.3 Interfacial Behavior of Phospholipid Monolayers.
1.2.4 Protein Layers at the Oil/Water Interface.
184.108.40.206 Kinetics of Protein Adsorption.
220.127.116.11 Formation of “Skin-Like” Protein Films on a Curved Interface.
1.2.5 Interfacial Behavior of Phospholipid/Protein Composite Layers.
18.104.22.168 Dynamic Adsorption and Mechanism.
22.214.171.124 Assembly of “Skin-Like” Complex Films on a Curved Interface.
1.3 Modeling Membrane Hydrolysis In Vitro.
1.4 Polyelectrolyte-Supported Lipid Bilayers.
1.4.1 Polyelectrolyte Multilayers on Planar Surfaces.
1.4.2 Polyelectrolyte Multilayers on Curved Surfaces.
1.5 Conclusions and Perspectives.
2 Layer-by-Layer Assembly of Biomimetic Microcapsules.
2.2 Layer-by-layer Assembly of Polyelectrolyte Multilayer Microcapsules.
2.2.1 General Aspects.
2.2.2 Permeation and Mechanical Properties of LbL Microcapsules.
2.3 Biointerfacing Polyelectrolyte Microcapsules – A Multifunctional Cargo System.
2.3.1 Lipid Bilayer-Modifi ed Polyelectrolyte Microcapsules.
2.3.2 Formation of Asymmetric Lipid Bilayers on the Surface of LbL-Assembled Capsules.
2.3.3 Assembly of Lipid Bilayers on Covalently LbL-Assembled Protein Capsules.
2.4 Application of Biomimetic Microcapsules.
2.4.1 Integrating Specifi c Biofunctionality for Targeting.
2.4.2 Adsorption of Antibodies on the Surface of Biomimetic Microcapsules.
2.5 Conclusions and Perspectives.
3 FoF1-ATP Synthase-Based Active Biomimetic Systems.
3.2 FoF1-ATPase – A Rotary Molecular Motor.
3.2.1 Structure of H+FoF1-ATPase.
3.2.2 Direct Observation of the Rotation of Single ATPase Molecules.
3.3 Reconstitution of FoF1-ATPase in Cellular Mimic Structures.
3.3.1 FoF1-ATPase-incorporated Liposome – A Classical Biomembrane Mimic.
126.96.36.199 Bacteriorhodopsin uses Light to Pump Protons.
188.8.131.52 Proton Gradients Produced by Artificial Photosynthetic Reactions.
3.3.2 ATP Biosynthesis from Biomimetic Microcapsules.
184.108.40.206 Generation of Proton Gradients in Polymer Capsules by the Change of pH Values.
220.127.116.11 Proton Gradients in Protein Capsules Supplied by the Oxidative Hydrolysis of Glucoses.
18.104.22.168 Proton Gradients Generated by GOD Capsules.
3.3.3 Reassembly of FoF1-ATPase in Polymersomes.
3.4 Conclusions and Perspectives.
4 Kinesin–Microtubule-Driven Active Biomimetic Systems.
4.2 Kinesin–Microtubule Active Transport Systems.
4.3 Active Biomimetic Systems Based on the Kinesin–Microtubule Complex.
4.3.1 Bead Geometry.
4.3.2 Gliding Geometry.
4.3.3 Transport Direction and Distance of Assembled Systems.
4.4 Layer-by-Layer Assembled Capsules as Cargo – A Promising Biomimetic System.
4.4.1 Layer-by-Layer Assembled Hollow Microcapsules.
4.4.2 Kinesin–Microtubule-Driven Microcapsule Systems.
22.214.171.124 Fabrication in a Beaded Geometry.
126.96.36.199 Fabrication in a Gliding Geometry.
4.5 Conclusions and Perspectives.
5 Biomimetic Interface.
5.2 Preparation and Characterization of Biomolecule Patterning.
5.2.1 Electrostatic Immobilization of Proteins for Surface Assays.
188.8.131.52 Lipid-Modified HSA Patterns for the Targeted Recognition.
184.108.40.206 Lipid-Modified HSA Patterns for Escherichia coli Recognition.
5.2.2 Covalent Immobilization of Proteins.
5.2.3 Covalent Immobilization of Lipid Monolayers.
5.3 Polymer Brush Patterns for Biomedical Application.
5.3.1 Thermosensitive Polymer Patterns for Cell Adhesion.
5.3.2 Fabrication of Complex Polymer Brush Gradients.
5.4 Conclusions and Perspectives.
6 Peptide-Based Biomimetic Materials.
6.2 Peptides as Building Blocks for the Bottom-up Fabrication of Various Nanostructures.
6.2.1 Aromatic Dipeptides.
220.127.116.11 Nanotubes, Nanotube Arrays, and Vesicles.
18.104.22.168 Nanofibrils and Ribbons.
22.214.171.124 Ordered Molecular Chains on Solid Surfaces.
6.2.4 Amphiphilic Peptides.
6.3 Peptide–Inorganic Hybrids.
6.3.1 Nonspecific Attachment of Inorganic Nanoparticles on Peptide-Based Scaffolds.
6.3.2 Peptide-Based Biomineralization.
6.3.3 Adaptive Hybrid Supramolecular Networks.
6.4 Applications of Peptide Biomimetic Nanomaterials.
6.4.1 Biological Applications.
126.96.36.199 Three-Dimensional Cell Culture Scaffolds for Tissue Engineering.
188.8.131.52 Delivery of Drugs or Genes.
6.4.2 Nonbiological Applications.
6.5 Conclusions and Perspectives.
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