The Molecular Basis of Blood Diseases / Edition 2

The Molecular Basis of Blood Diseases / Edition 2

by George Stamatoyannopoulos, Arthur W. Nienhuis, Philip W. Majerus, Harold E. Varmus
     
 

The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such

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Overview

The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such as signaling and antigen presentation by B-lymphocytes, molecular oncogenesis and more!

Product Details

ISBN-13:
9780721647357
Publisher:
Elsevier Health Sciences
Publication date:
01/28/1994
Edition description:
Older Edition
Pages:
986
Product dimensions:
8.66(w) x 11.42(h) x (d)

Meet the Author

Professor of Medicine, Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA

Professor of Medicine and Biological Chemistry, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO

Executive Vice President of Basic Research, Merck Research Laboratories, Rahway, NJ

President and Chief Executive Officer, Memorial Sloan-Kettering Cancer Center, Professor of Cell Biology and Genetics, Cornell Medical School, New York, NY

Table of Contents

Sect. IBasic Concepts
1Methods of Molecular Genetics3
2Mechanisms of Eukaryotic Gene Regulation33
3Hematopoiesis71
Sect. IIRed Cells and Erythropoiesis
4Hemoglobin Switching107
5The Thalassemias157
6Sickle Hemoglobin and Other Hemoglobin Mutants207
7The Erythrocyte Membrane and Cytoskeleton: Structure, Function, and Disorders257
8Red Cell Membrane Antigens293
9The Molecular Biology of Enzymes of Erythrocyte Metabolism331
10Molecular Mechanisms of Iron Metabolism351
Sect. IIILymphopoiesis
11Gene Rearrangements in Lymphoid Cells381
12Lymphopoiesis425
13Antigen Processing and T-Cell Effector Mechanisms463
Sect. IVWhite Cells
14Genetic Disorders of Phagocyte Function493
15The Molecular Basis of White Blood Cell Motility541
Sect. VHemostasis
16Vitamin K-Dependent Proteins565
17The Protein C Anticoagulant System599
18Regulation of Blood Coagulation by Protease Inhibitors629
19Hemophilia A, Hemophilia B, and von Willebrand Disease657
20The Molecular Biology of Fibrin701
21Fibrinolysis and the Control of Hemostasis725
22Platelets753
Sect. VIMolecular Oncology
23Molecular Aspects of Oncogenesis789
24Mechanisms of Leukemogenesis835
Sect. VIIViruses
25The Molecular and Biological Properties of the Human Immunodeficiency Virus863
26Viral Pathogenesis of Hematological Disorders909
Introduction910
A. B19 Parvovirus911
B. Retroviruses (HTLVs)929
C. Herpesviruses943
Index957

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