The Molecular Basis of Blood Diseases / Edition 2

The Molecular Basis of Blood Diseases / Edition 2

by George Stamatoyannopoulos, Arthur W. Nienhuis, Philip W. Majerus, Harold E. Varmus
     
 

ISBN-10: 0721647359

ISBN-13: 9780721647357

Pub. Date: 01/28/1994

Publisher: Elsevier Health Sciences

The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such

Overview

The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such as signaling and antigen presentation by B-lymphocytes, molecular oncogenesis and more!

Product Details

ISBN-13:
9780721647357
Publisher:
Elsevier Health Sciences
Publication date:
01/28/1994
Edition description:
Older Edition
Pages:
986
Product dimensions:
8.66(w) x 11.42(h) x (d)

Table of Contents

PART I: Hematopoiesis
Stem Cell Biology
Hemopoietic Growth Factors and Receptors
Transcriptional Factors that Regulate Lineage Decisions
Growth Factor Signaling

PART II: Red Cells
Hemoglobin Switching
The Thalassemias
Human Hemoglobins: Sickle Cell Hemoglobin and Other Mutants
The Erythrocyte Membrane and Cytoskeleton: Structure, Function, and Disorders
Red Blood Cell Antigenes
Molecular Basis of Iron Metabolism

PART III: Lymphopoiesis
Gene rearrangements in Lymhoic Cells
Lymphoiesis
Antigen Processing and T-Cell Effector Mechanisms

PART IV: Myelopoiesis/White Blood Cells
Integrins, Selectins, and LAD
Chemokines
Genetic Disorders of Phagocyte Function
Paroxymal Nocturnal Hemoglobins

PART V: Hemostasis
Vitamin K-Dependent Proteins
The Protein C Anticoagulant System
Regulation of Blood Coagulation by Protease Inhibitors
Hemophilia A, Hemophilia B, and von Willenbrand Disease
The Molecular Basis of Fibrin
Fibrinilysis and the Control of Hemostasis
Platelets

PART VI: Molecular Oncology
Molecular Aspects of Oncogenesis
Mechanisms of Leukemogenesis

PART VII: Viruses
The Molecular and Biological Properties of the Human Immunodeficiency Virus
Viral Pathogenesis of Hematological Disorders
B19 Parvoviruses
HTLVs
Herpesviruses
Gene Therapy of Hemopoietic Diseases

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