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The Molecular Basis of Cancer: Expert Consult - Online and Print / Edition 3

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Overview

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and now as an Expert Consult title, it enables you to conveniently search the entire text online, download all of the book’s images for your personal use, and review periodic updates.
  • Offers online access the book's complete contents—fully searchable—along with periodic updates, and artwork from the text for your personal use.
  • Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty.
  • Offers a new, more user-friendly full-color format so the information that you need is easier to find.
  • Presents abundant figures—all redrawn in full color—illustrating major concepts for easier comprehension.
  • Features numerous descriptions of the latest clinical strategies—helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.

The book contains black-and-white illustrations.

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Editorial Reviews

From The Critics
“Each chapter is written by a well-known authority in the respective field...An outstanding achievement.” – Journal of the National Cancer Institute, review of the 1st edition

“Easy to read but contains a wealth of information...achieves its goal of being both educational and exhaustive.” – The Cancer Bulletin, review of the 1st edition

From the Publisher
"This is a well-organized and well-written book that improves readers' understanding of the diverse mechanisms involved in cancer risk, growth, and treatments. The book provides a unique experience, uniting basic science with clinical applications to provide an integrated appreciation of the diverse molecular biology of cancer. It should be in the library of anyone interested in cancer research and treatment."-Karen L Reckamp, MD, MS(City of Hope) Doody Review: 4 stars
Doody's Review Service
Reviewer: Karen L Reckamp, MD, MS (City of Hope)
Description: Cancer and its molecular basis encompasses a broad scope of biology that includes genetics and epigenetics, cell cycle regulation, tumor microenvironment and angiogenesis, and immunology partnered with clinical applications and complex bioinformatics to improve treatments for patients. The rapid pace of discovery in the molecular biology of cancer requires continued evaluation of the data to understand and integrate the advances. The objective of this book is to provide information regarding the mechanisms that result in carcinogenesis and therapeutic interventions for cancer.
Purpose: The aims are to explain the genetic and molecular mechanisms of cancer development, growth, and metastasis in a sequential manner, then describe the progress made in analytic technologies and bioinformatics that allow for precision medicine in cancer diagnostics and treatment. Finally, the book presents the underlying molecular biology and advances to demonstrate current cancer care and implications for future approaches.
Audience: The intended audience includes clinicians and healthcare professionals who care for cancer patients, as well as clinical and laboratory-based biomedical researchers and advanced students and trainees.
Features: With this fourth edition, the book has been expanded and the content adapted to reflect the evolving field of molecular biology in cancer to maintain its relevance in cancer care. This book brings together an exceptional group of authors with the expertise to educate its audience on the molecular underpinnings of cancer and its applications. Chapters can be read individually or in the context of the full work that moves through mechanisms and biology to the analysis of complex data and understanding of therapy. The figures and tables enhance comprehension.
Assessment: This is a well-organized and well-written book that improves readers' understanding of the diverse mechanisms involved in cancer risk, growth, and treatments. The book provides a unique experience, uniting basic science with clinical applications to provide an integrated appreciation of the diverse molecular biology of cancer. It should be in the library of anyone interested in cancer research and treatment.
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Product Details

  • ISBN-13: 9781416037033
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/26/2008
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 704
  • Product dimensions: 8.80 (w) x 11.10 (h) x 1.40 (d)

Table of Contents

Sect. I Malignant Transformation
1 Cancer: A Genetic Disorder 3
2 Regulation of the Cell Cycle 10
3 Programmed Cell Death and Senescence 19
4 Progressive Genetic Abnormalities in Human Neoplasia 41
5 Viral Carcinogenesis 71
6 Tumor Suppressor Genes 95
7 Oncogenes and Signal Transduction 115
Sect. II Growth and Spread of Cancer
8 Growth Factors and Their Receptors in Epithelial Malignancies 137
9 Metastasis and Angiogenesis: Molecular Dissection and Novel Applications 163
10 Tumor Angiogenesis 173
Sect. III Molecular Pathogenesis of Specific Malignancies
11 Molecular Biology of Non-Hodgkin's Lymphoma and Multiple Myeloma 189
12 Molecular Genetics of Acute Lymphoblastic Leukemia 213
13 Molecular Biology of Childhood Neoplasms 239
14 Molecular Biology of Lung Cancer 260
15 Molecular Abnormalities in Colon and Rectal Cancer 289
16 Molecular Basis of Breast Cancer 313
17 Molecular Biology of Prostate Cancer 343
18 Molecular Pathogenesis of Ovarian Cancer 361
19 Molecular Biology of Melanoma 385
Sect. IV Molecular Basis of Cancer Therapy
20 Natural and Acquired Resistance to Chemotherapeutic Agents 407
21 Radiation Therapy 423
22 Monoclonal Antibodies 467
23 Interferons and Hematopoietic Cytokines 503
24 Cellular Immunity and Cytokines 535
25 Cancer-Specific Vaccines 573
26 Gene Therapy 589
27 Molecular Markers in Cancer Therapy: Evolution of a Concept 605
28 Molecular Mechanisms of Chemoprevention and Differentiation Therapy 621
29 Counseling for Hereditary Cancer Risk 649
Index 667
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