Molecular Basis of Cancer / Edition 1

Molecular Basis of Cancer / Edition 1

by John Mendelsohn, Peter M. Howley, Lance A. Liotta, Mark A. Israel
     
 

ISBN-10: 0721664830

ISBN-13: 9780721664835

Pub. Date: 12/28/1994

Publisher: Elsevier Health Sciences

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and…  See more details below

Overview

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and practice.
Incorporating the latest advances and newest research, this text also gives thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for Numerous examples of the latest clinical interventions help readers understand and assess the products of the biotechnology revolution. Each chapter discusses the clinical implications for treatment.

Product Details

ISBN-13:
9780721664835
Publisher:
Elsevier Health Sciences
Publication date:
12/28/1994
Edition description:
Older Edition
Pages:
573
Product dimensions:
8.66(w) x 11.02(h) x (d)

Table of Contents

Sect. IMalignant Transformation
1Cancer: A Genetic Disorder3
2Regulation of the Cell Cycle10
3Programmed Cell Death and Senescence19
4Progressive Genetic Abnormalities in Human Neoplasia41
5Viral Carcinogenesis71
6Tumor Suppressor Genes95
7Oncogenes and Signal Transduction115
Sect. IIGrowth and Spread of Cancer
8Growth Factors and Their Receptors in Epithelial Malignancies137
9Metastasis and Angiogenesis: Molecular Dissection and Novel Applications163
10Tumor Angiogenesis173
Sect. IIIMolecular Pathogenesis of Specific Malignancies
11Molecular Biology of Non-Hodgkin's Lymphoma and Multiple Myeloma189
12Molecular Genetics of Acute Lymphoblastic Leukemia213
13Molecular Biology of Childhood Neoplasms239
14Molecular Biology of Lung Cancer260
15Molecular Abnormalities in Colon and Rectal Cancer289
16Molecular Basis of Breast Cancer313
17Molecular Biology of Prostate Cancer343
18Molecular Pathogenesis of Ovarian Cancer361
19Molecular Biology of Melanoma385
Sect. IVMolecular Basis of Cancer Therapy
20Natural and Acquired Resistance to Chemotherapeutic Agents407
21Radiation Therapy423
22Monoclonal Antibodies467
23Interferons and Hematopoietic Cytokines503
24Cellular Immunity and Cytokines535
25Cancer-Specific Vaccines573
26Gene Therapy589
27Molecular Markers in Cancer Therapy: Evolution of a Concept605
28Molecular Mechanisms of Chemoprevention and Differentiation Therapy621
29Counseling for Hereditary Cancer Risk649
Index667

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