Molecular Basis of Cancer

Overview

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating the latest advances and newest research, this text also gives thorough descriptions of everything from the basic mechanisms of ...

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Overview

The state-of-the-art 2nd Edition of this acclaimed reference explains the principles that form the scientific basis for our understanding of malignant transformation and the pathogenesis and treatment of cancer. Readers will find a broad update on the scientific principles of new diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating the latest advances and newest research, this text also gives thorough descriptions of everything from the basic mechanisms of malignant cells and molecular abnormalities in common cancers to new approaches for cancer therapy. Each chapter discusses the clinical implications for treatment. Numerous examples of the latest clinical interventions help readers understand and assess the products of the biotechnology revolution.

• IMPORTANT new topics, including chemo-prevention, programmed cell death (apoptosis), genetic counselling, tumour-specific vaccines, genetic abnormalities in the origin and progression of cancer, monoclonal antibody therapy, and molecular predictors of prognosis and response to treatment

• NEW and revised chapters, covering new basic science knowledge, new approaches to treatment and keeping all information on the cutting-edge of the specialty

• ABUNDANT illustrations, most of them new, to clarify and explain difficult concepts.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780721672915
  • Publisher: Elsevier Health Sciences
  • Publication date: 7/2/2001
  • Edition description: REV
  • Edition number: 2
  • Pages: 720
  • Product dimensions: 8.78 (w) x 11.45 (h) x 1.28 (d)

Table of Contents

Section I: Malignant Transformation
1. Cancer: A Genetic Disorder
2. Regulation of the Cell Cycle
3. Programmed Cell Death and Senescence
4. Progressive Genetic Abnormalities in Human Neoplasia
5. Viral Carcinogenesis
6. Tumor Suppressor Genes
7. Oncogenes and Signal Transduction

Section II: Growth and Spread of Cancer
8. Growth Factors and Their Receptors in Epithelial Malignancies
Metastasis and Angiogenesis: Molecular Dissection and Novel Applications
9. Adhesions and Mechanisms
10. Tumor Angiogenesis and Antiangiogenesis

Section III: Molecular Pathogenesis of Specific Malignancies
11. Molecular Biology of Non-Hodgkin's Lymphoma and Multiple Myeloma
12. Molecular Genetics of Acute Lymphoblastic Leukemia
13. Molecular Biology of Childhood Neoplasms
14. Molecular Biology of Lung Cancer
15. Molecular Abnormalities in Colon and Rectal Cancer
16. Molecular Basis of Breast Cancer
17. Prostate Cancer
18. Molecular Pathogenesis of Ovarian Cancer
19. Molecular Biology of Melanoma

Section IV: Molecular Basis of Cancer Therapy
20. Natural and Acquired Resistance to Chemotherapeutic Agents
21. Radiation Therapy
22. Monoclonal Antibodies
23. Interferons and Hematopoietic Cytokines
24. Cellular Immunity and Cytokines
25. Cancer-Specific Vaccines
26. Molecular Basis of Cancer Therapy
27. Molecular Markers in Cancer Therapy: Evolution of a Concept
28. Molecular Mechanisms of Chemoprevention and Differentiation Therapy
29. Counseling for Hereditary Cancer Risk

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