Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease

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The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease · the molecular basis of ischemic disease, thrombosis and hypertension · genetic mapping approaches to inherited disorders · biologically targeted agents for hypertension and heart failure · and much more. Abundant figures and tables ...

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Overview

The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease · the molecular basis of ischemic disease, thrombosis and hypertension · genetic mapping approaches to inherited disorders · biologically targeted agents for hypertension and heart failure · and much more. Abundant figures and tables illustrate key concepts.

• Addresses most common cardiovascular problems from a molecular standpoint.
• Explores developing treatments for cardiovascular problems based on genetics.
• Provides references to Braunwald's Heart Disease, 6th Edition

• Examines today's cutting edge advances in molecular cardiology and the future of gene therapy,
• Examines the implications of cellular cholesterol metabolism in health and disease.
• Delivers up-to-date information on understanding the origin of inherited disease.

With 55 additional contributing experts.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Product Details

  • ISBN-13: 9780721664019
  • Publisher: Elsevier Health Sciences
  • Publication date: 10/19/1998
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 637

Table of Contents

Sect. 1 General principles of molecular cardiology
1 Biotechnology and cardiovascular medicine : recombinant protein therapy 1
2 Human genome project and cardiovascular disease genes 16
3 Model organisms for cardiac disease gene discovery 39
4 Generation and cloning of genetically modified animals 49
5 Mouse models of human cardiovascular disease 72
6 Toward stem cell therapy 107
7 Cardiovascular signaling pathways 123
8 Genetic approaches to cardiovascular disease 175
9 Gene transfer approaches for cardiovascular disease 195
Sect. 2 Cardiac development and congenital heart disease
10 Cardiac development and congenital heart disease 217
11 Development of cardiac pacemaking and conduction system lineages 225
12 Cardiac laterality and congenital heart disease 238
13 Pharyngeal apparatus and cardiac neural crest defects 249
14 Monogenic causes of congenital heart disease 261
Sect. 3 Cardiac muscle diseases
15 Molecular pathways for cardiac hypertrophy and heart failure progression 273
16 Molecular genetics of inherited cardiomyopathies 293
17 Molecular pathways for dilated cardiomyopathy 306
18 Excitability and conduction 311
19 Cardiac arrhythmias : inherited molecular mechanisms 336
Sect. 4 Atherogenesis
20 Inflammation and immunity in atherogenesis 349
21 Molecular biology of lipoproteins and dyslipidemias 365
22 Lipoprotein oxidation, macrophages, immunity, and atherogenesis 385
23 Cellular cholesterol metabolism in health and disease 414
Sect. 5 Ischemic diseases and angiogenesis
24 Angiogenesis in cardiovascular disease 433
25 Coronary restenosis 455
26 Molecular basis for the potential use of NMDA receptor open-channel blockers in the treatment of cerebral ischemia and other brain insults 470
Sect. 6 Thrombosis
27 Platelets and antiplatelet therapy in cardiovascular disease : molecular mechanisms 479
28 Blood coagulation and atherothrombosis 498
29 Thrombosis and thrombolytic therapy 519
Sect. 7 Hypertension
30 Molecular targets of antihypertensive drug therapy 539
31 Mechanisms and molecular pathways in hypertension 566
Sect. 8 Environmental and genetic modifications of cardiovascular disease
32 Molecular biology of transplantation and xenotransplantation 649
33 Viral infections of the heart 667
Index 684
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