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Doody's Review ServiceReviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book provides current information on the molecular basis of tumorigenesis. The contributors are well known basic and clinical scientists, mainly from the United States.
Purpose: The purpose is to provide an overview of unifying concepts that pertain to carcinogenesis and then to demonstrate how these concepts are integrated in particular cancers. Detailed mechanisms relating to cancer development are provided for the more common cancers including breast and prostate.
Audience: The book is geared primarily to graduate and medical students, but it would also be useful to seasoned researchers as it provides a good overview of a number of important themes in carcinogenesis.
Features: The book is divided into seven parts. The first five parts, which make up about half the book, provide an overview of the causes of human cancers and of pertinent themes in oncogenesis. Part six provides in-depth information on mechanisms governing cancer development in the breast, prostate, lung, liver, colon, skin, leukemias, and lymphomas. Part seven describes how the information in the earlier parts of the book can help in the diagnosis and treatment of cancers. It is an easy to read book with a number of good illustrations. It is also very well referenced, though the references are slightly outdated.
Assessment: On the whole, this is a well-written and well-referenced book on the genetics of cancer. It does provide easy-to-read information on a number of important themes pertaining to carcinogenesis. Unfortunately, like many other such books, it is a little outdated. Overall, this book would be useful to those who are interested in getting an overview of the field of human carcinogenesis.