The Molecular Basis of Human Cancer / Edition 1

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Internationally renowned basic and clinical scientists provide an acco unt of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molec ular mechanisms governing neoplastic transformation in the breast, pro state, lung, liver, colon, and skin, and in the leukemias and lymphoma s. Their discussion illuminates both recent developments and establish ed concepts in epidemiology, molecular techniques, oncogenesis, and mu tation mechanisms, as well as the chemical, viral, and physical mechan isms in cancer induction.

"...covers general molecular concepts in neoplastic trans- formation, state-of-the-art descriptions of molecular mecha- nisms in specific human cancers, & rapidly evolving aspects of cancer research & treatment."

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Editorial Reviews

Doody's Review Service
Reviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book provides current information on the molecular basis of tumorigenesis. The contributors are well known basic and clinical scientists, mainly from the United States.
Purpose: The purpose is to provide an overview of unifying concepts that pertain to carcinogenesis and then to demonstrate how these concepts are integrated in particular cancers. Detailed mechanisms relating to cancer development are provided for the more common cancers including breast and prostate.
Audience: The book is geared primarily to graduate and medical students, but it would also be useful to seasoned researchers as it provides a good overview of a number of important themes in carcinogenesis.
Features: The book is divided into seven parts. The first five parts, which make up about half the book, provide an overview of the causes of human cancers and of pertinent themes in oncogenesis. Part six provides in-depth information on mechanisms governing cancer development in the breast, prostate, lung, liver, colon, skin, leukemias, and lymphomas. Part seven describes how the information in the earlier parts of the book can help in the diagnosis and treatment of cancers. It is an easy to read book with a number of good illustrations. It is also very well referenced, though the references are slightly outdated.
Assessment: On the whole, this is a well-written and well-referenced book on the genetics of cancer. It does provide easy-to-read information on a number of important themes pertaining to carcinogenesis. Unfortunately, like many other such books, it is a little outdated. Overall, this book would be useful to those who are interested in getting an overview of the field of human carcinogenesis.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896036345
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 8/28/2001
  • Edition description: 2002
  • Edition number: 1
  • Pages: 588
  • Product dimensions: 8.50 (w) x 11.90 (h) x 1.60 (d)

Table of Contents

Part I. Introduction

Cancer Epidemiology: Incidence and Etiology of Human Neoplasms

William B. Coleman and Gregory J. Tsongalis

Part II. Essential Concepts in Molecular Biology

Essential Concepts and Techniques in Molecular Biology

Sharon Collins Presnell

Part III. Molecular Themes in Oncogenesis

Cancer Genes

John J. Reinartz

Positive Mediators of Cell Proliferation in Neoplastic Transformation

James N. Welch and Susan A. Chrysogelos

Inactivation of Negative Growth Regulators During Neoplastic Transformation

Kara N. Smolinski and Stephen J. Meltzer

Part IV. Mechanisms of Mutation

The Role of Genomic Instability in the Development of Human Cancer

William B. Coleman and Gregory J. Tsongalis

Chromosomes and Chromosomal Instability in Human Cancer

Takashi Shimamoto and Kazuma Ohyashiki

Hereditary Cancer

Bruce M. Boman, Lael Melchert, and Jeremy Z. Fields

Part V. Etiology of Human Cancers

Evolution of Research in Cancer Etiology

Lorenzo Tomatis and James Huff

Cellular Responses to Chemical Carcinogens

Edward L. Loechler, Bryan Henry, and Kwang-Young Seo

Physical Agents in Human Carcinogenesis

Cynthia R. Timblin, Yvonne Janssen-Heininger, and Brooke T. Mossman

Viral Mechanisms of Human Carcinogenesis

Felix Hoppe-Seyler and Karin Butz

Part VI. Human Tumor Systems

The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway

J. Milburn Jessup, Gary Gallick, and Bo Liu

Molecular Genetic Alterations in Primary Hepaellular Neoplasms: Hepaellular Adenoma, Hepaellular Carcinoma, and Hepatoblastoma

Joe W. Grisham

The Molecular Basis of Breast Carcinogenesis

April Charpentier and C. Marcelo Aldaz

The Molecular Basis of Prostate Carcinogenesis

Allen C. Gao and John T. Isaacs

The Molecular Basis of Lung Carcinogenesis

Kwun M. Fong, Yoshitaka Sekido, and John D. Minna

The Molecular Basis of Skin Carcinogenesis

Caterina Missero, Mariarosaria D'Errico, Gian Paolo Dotto, and Eugenia Dogliotti

The Molecular Biology of Leukemias

Arnold B. Gelb and L. Jeffrey Medeiros

Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma

Gregory J. Tsongalis and William N. Rezuke

Part VII. Future Directions

Cancer Genetic Counseling

Katherine Schneider, Kristen Shannon, Anu Chittenden, Elaine Hiller, and Stephanie Kieffer

Molecular Genetic Diagnosis of Inherited Cancer Predisposition

Elizabeth M. Petty and Beverly M. Yashar

Novel Molecular Targets for Cancer Drug Discovery

John K. Buolamwini

Gene Therapy in the Treatment of Human Cancer

Jesús Gómez-Navarro, Guadalupe Bilbao, and David T. Curiel

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