The Molecular Basis of Human Cancer / Edition 2

Hardcover (Print)
Not Available on


Internationally renowned basic and clinical scientists provide an acco unt of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molec ular mechanisms governing neoplastic transformation in the breast, pro state, lung, liver, colon, and skin, and in the leukemias and lymphoma s. Their discussion illuminates both recent developments and establish ed concepts in epidemiology, molecular techniques, oncogenesis, and mu tation mechanisms, as well as the chemical, viral, and physical mechan isms in cancer induction.

"...covers general molecular concepts in neoplastic trans- formation, state-of-the-art descriptions of molecular mecha- nisms in specific human cancers, & rapidly evolving aspects of cancer research & treatment."

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book provides current information on the molecular basis of tumorigenesis. The contributors are well known basic and clinical scientists, mainly from the United States.
Purpose: The purpose is to provide an overview of unifying concepts that pertain to carcinogenesis and then to demonstrate how these concepts are integrated in particular cancers. Detailed mechanisms relating to cancer development are provided for the more common cancers including breast and prostate.
Audience: The book is geared primarily to graduate and medical students, but it would also be useful to seasoned researchers as it provides a good overview of a number of important themes in carcinogenesis.
Features: The book is divided into seven parts. The first five parts, which make up about half the book, provide an overview of the causes of human cancers and of pertinent themes in oncogenesis. Part six provides in-depth information on mechanisms governing cancer development in the breast, prostate, lung, liver, colon, skin, leukemias, and lymphomas. Part seven describes how the information in the earlier parts of the book can help in the diagnosis and treatment of cancers. It is an easy to read book with a number of good illustrations. It is also very well referenced, though the references are slightly outdated.
Assessment: On the whole, this is a well-written and well-referenced book on the genetics of cancer. It does provide easy-to-read information on a number of important themes pertaining to carcinogenesis. Unfortunately, like many other such books, it is a little outdated. Overall, this book would be useful to those who are interested in getting an overview of the field of human carcinogenesis.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9781934115183
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/1/2011
  • Edition number: 2
  • Pages: 800

Table of Contents

Pt. I Introduction
1 Cancer Epidemiology: Incidence and Etiology of Human Neoplasms 3
Pt. II Essential Concepts in Molecular Biology
2 Essential Concepts and Techniques in Molecular Biology 25
Pt. III Molecular Themes in Oncogenesis
3 Cancer Genes 45
4 Positive Mediators of Cell Proliferation in Neoplastic Transformation 65
5 Inactivation of Negative Growth Regulators During Neoplastic Transformation 81
Pt. IV Mechanisms of Mutation
6 The Role of Genomic Instability in the Development of Human Cancer 115
7 Chromosomes and Chromosomal Instability in Human Cancer 143
8 Hereditary Cancer 159
Pt. V Etiology of Human Cancers
9 Evolution of Research in Cancer Etiology 189
10 Cellular Responses to Chemical Carcinogens 203
11 Physical Agents in Human Carcinogenesis 223
12 Viral Mechanisms of Human Carcinogenesis 233
Pt. VI Human Tumor Systems
13 The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway 251
14 Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma 269
15 The Molecular Basis of Breast Carcinogenesis 347
16 The Molecular Basis of Prostate Carcinogenesis 365
17 The Molecular Basis of Lung Carcinogenesis 379
18 The Molecular Basis of Skin Carcinogenesis 407
19 The Molecular Biology of Leukemias 427
20 Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma 461
Pt. VII Future Directions
21 Cancer Genetic Counseling 477
22 Molecular Genetic Diagnosis of Inherited Cancer Predisposition 497
23 Novel Molecular Targets for Cancer Drug Discovery 521
24 Gene Therapy in the Treatment of Human Cancer 541
Index 567
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)