The Molecular Basis of Human Cancer / Edition 2

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Overview

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

"...covers general molecular concepts in neoplastic trans- formation, state-of-the-art descriptions of molecular mecha- nisms in specific human cancers, & rapidly evolving aspects of cancer research & treatment."

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Editorial Reviews

Doody's Review Service
Reviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book provides current information on the molecular basis of tumorigenesis. The contributors are well known basic and clinical scientists, mainly from the United States.
Purpose: The purpose is to provide an overview of unifying concepts that pertain to carcinogenesis and then to demonstrate how these concepts are integrated in particular cancers. Detailed mechanisms relating to cancer development are provided for the more common cancers including breast and prostate.
Audience: The book is geared primarily to graduate and medical students, but it would also be useful to seasoned researchers as it provides a good overview of a number of important themes in carcinogenesis.
Features: The book is divided into seven parts. The first five parts, which make up about half the book, provide an overview of the causes of human cancers and of pertinent themes in oncogenesis. Part six provides in-depth information on mechanisms governing cancer development in the breast, prostate, lung, liver, colon, skin, leukemias, and lymphomas. Part seven describes how the information in the earlier parts of the book can help in the diagnosis and treatment of cancers. It is an easy to read book with a number of good illustrations. It is also very well referenced, though the references are slightly outdated.
Assessment: On the whole, this is a well-written and well-referenced book on the genetics of cancer. It does provide easy-to-read information on a number of important themes pertaining to carcinogenesis. Unfortunately, like many other such books, it is a little outdated. Overall, this book would be useful to those who are interested in getting an overview of the field of human carcinogenesis.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781934115183
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/1/2011
  • Edition number: 2
  • Pages: 800

Table of Contents

Preface
Dedication
Contributors
Pt. I Introduction
1 Cancer Epidemiology: Incidence and Etiology of Human Neoplasms 3
Pt. II Essential Concepts in Molecular Biology
2 Essential Concepts and Techniques in Molecular Biology 25
Pt. III Molecular Themes in Oncogenesis
3 Cancer Genes 45
4 Positive Mediators of Cell Proliferation in Neoplastic Transformation 65
5 Inactivation of Negative Growth Regulators During Neoplastic Transformation 81
Pt. IV Mechanisms of Mutation
6 The Role of Genomic Instability in the Development of Human Cancer 115
7 Chromosomes and Chromosomal Instability in Human Cancer 143
8 Hereditary Cancer 159
Pt. V Etiology of Human Cancers
9 Evolution of Research in Cancer Etiology 189
10 Cellular Responses to Chemical Carcinogens 203
11 Physical Agents in Human Carcinogenesis 223
12 Viral Mechanisms of Human Carcinogenesis 233
Pt. VI Human Tumor Systems
13 The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway 251
14 Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma 269
15 The Molecular Basis of Breast Carcinogenesis 347
16 The Molecular Basis of Prostate Carcinogenesis 365
17 The Molecular Basis of Lung Carcinogenesis 379
18 The Molecular Basis of Skin Carcinogenesis 407
19 The Molecular Biology of Leukemias 427
20 Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma 461
Pt. VII Future Directions
21 Cancer Genetic Counseling 477
22 Molecular Genetic Diagnosis of Inherited Cancer Predisposition 497
23 Novel Molecular Targets for Cancer Drug Discovery 521
24 Gene Therapy in the Treatment of Human Cancer 541
Index 567
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