Molecular Basis of Thrombosis and Hemostasis / Edition 1

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Overview

This unique, single-source reference provides comprehensive coverage of the molecular biology and genetics of the factors involved in blood clotting and fibrinolytic systems as well as the antiproteases that control those reactions.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Gerald A Soff, M.D.(Northwestern University Feinberg School of Medicine)
Description: This is a complete molecular biology guide to thrombosis and hemostasis. It is a multiauthored effort and thoroughly explores current knowledge of the field of blood coagulation.
Purpose: It serves as a reference for those scientists and clinicians with a clinical or research interest in blood coagulation. Although narrowly focused, it is well done and will add to our information resources.
Audience: It is a reference for clinical and research hematologists, and any doing research in blood coagulation. Some clinical pathologists may also find it useful.
Features: It is a well-written, well-presented text, and the figures (all black-and-white) are well done. The index is helpful, but some smaller subtopics are not indexed. The references are current and comprehensive. The overall presentation and appearance are very good.
Assessment: This will be a valuable reference for medical libraries. Only devoted students of hematology will likely buy their own copy, but those that do will find it helpful in research and education. It compares favorably to the other new thrombosis texts, but the potential audience is limited by the pure basic science focus of the text.
Gerald A. Soff
This is a complete molecular biology guide to thrombosis and hemostasis. It is a multiauthored effort and thoroughly explores current knowledge of the field of blood coagulation. It serves as a reference for those scientists and clinicians with a clinical or research interest in blood coagulation. Although narrowly focused, it is well done and will add to our information resources. It is a reference for clinical and research hematologists, and any doing research in blood coagulation. Some clinical pathologists may also find it useful. It is a well-written, well-presented text, and the figures (all black-and-white) are well done. The index is helpful, but some smaller subtopics are not indexed. The references are current and comprehensive. The overall presentation and appearance are very good. This will be a valuable reference for medical libraries. Only devoted students of hematology will likely buy their own copy, but those that do will find it helpful in research and education. It compares favorably to the other new thrombosis texts, but the potential audience is limited by the pure basic science focus of the text.
Booknews
Summarizes recent advances in the field of hemostasis and thrombosis, with an emphasis on findings that have emerged through the application of molecular biology to coagulation. Following introductory overview chapters on molecular genetics and the coagulation reactions, the volume contains 30 chapters grouped in four sections: procoagulant proteins; anticoagulant proteins and their regulators; fibrinolytic system; and platelets. Among the specific topics: the molecular bases of von Willebrand disease; tissue factor pathway inhibitor; plasminogen activator inhibitors; and the molecular and cellular biology of thrombopoietin, the MPL ligand. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824795016
  • Publisher: Taylor & Francis
  • Publication date: 1/1/1995
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 688
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.50 (d)

Table of Contents

Molecular Genetics: An Overview, Peter J. Larson and Katherine A. High Overview of the Coagulation Reactions, Harold R. Roberts and Aldo Hugo Tabares

Procoagulant Proteins

Fibrinogen, Susan T. Lord Prothrombin, Sandra J. Friezner Degen Tissue Factor, James H. Morrissey Factor V, Thomas L. Ortel, Frank G. Keller, and William H. Kane Factor VII, Lars C. Petersen, Peter Wildgoose, and Ulla Hedner Factor VIII, E. G. D. Tuddenham The Molecular Bases of Von Willebrand Disease, Jerry Ware and Zaverio M. Ruggeri Factor IX, Katherine A. High and Harold R. Roberts Factor X, Herbert H. Watzke and Katherine A. High Factor XI, Kazuo Fujikawa and Dominic W. Chung Factor XII, Prekallikrein, and High-Molecular-Weight Kininogen, Hidehiko Saito and Tetsuhito Kojima Factor XIII, Thung-Shenq Lai and Charles S. Greenberg Vitamin K-Dependent g-glutamyl Carboxylase, David J. Wright, Daniel P. Morris, and Darrel W. Stafford

Anticoagulant Proteins and Their Regulators

Tissue Factor Pathway Inhibitor, Tze-Chein Wun Antithrombin: Structure and Function, William P. Sheffield, Ye I. Wu, and Morris A. Blajchman Heparin Cofactor II, Frank C. Church, Rebecca A. Shirk, and Jeanne E. Phillips Protein C, Koji Suzuki Thrombomodulin, William A. Ditman and Stephen C. Nelson Protein C Inhibitor, Rebecca A. Shirk, Jeanne E. Phillips, and Frank C. Church Protein S, Koji Suzuki

Fibrinolytic System

Tissue-Type Plasminogen Activator, M. Sharon Stack, Edwin L. Madison, and Salvatore V. Pizzo Plasminogen, Francis J. Castellino Plasminogen Activator Inhibitors, Daniel A. Lawrence and David Ginsburg a2-Plasmin Inhibitor, Nobuo Aoki

Platelets

Human Platelet Glycoprotein Ib and the Ib-V-IX System: The Receptor for Platelet Adhesion in Arteries, Gerald J. Roth Platelet Glycoproteins IIb and IIIa, Joel S. Bennett and Mortimer Poncz Platelet Integrins Other than Glycoprotein IIb-IIIa, (aIIbb3), Samuel A. Santoro Thrombospondins, Jack Lawler Platelet Thrombin Receptor, Shaun R. Coughlin The Molecular and Cellular Biology of Thrombopoietin, The MPL Ligand, Kenneth Kaushansky and Si Lok

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