Molecular Biology / Edition 2

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Overview

"Clark effectively introduces basic concepts followed by more specific applications as the discussion evolves. He has included current research results and takes a thorough look at the medical, agricultural, and social aspects that shape modern-day molecular biology. This text is concisely written and beautifully illustrated in full color, to help student readers stay engaged and focused on understanding." Molecular Biology covers a broad range of topics to reinforce that molecular biology is applicable to more than just human medicine and health, but also applies to veterinary medicine, evolution, agriculture, and biotechnology.

Molecular biology is a fast-paced field that constantly provides new insights into the living world and the role of humans within it. Students and professionals need a clear understanding of new discoveries and applications, as well as a firm grasp of the fundmental concepts. Clark's Molecular Biology: Understanding the Genetic Revolution gives readers what they need in both regards.

Clark effectively introduces basic concepts followed by more specific applications as the text evolves. He has included research results as current as late 2004 when the gene count for humans was officially changed, and takes a thorough look at the medical, agricultural, and social aspects that shape modern-day molecular biology. This text is written in a straightforward manner and beautifully illustrated in full color.

Molecular Biology covers a deliberately broad range of topics to show that molecular biology is not applicable merely to human medicine and health, but also applies to veterinary medicine, evolution, agriculture, and other areas. Up to date description of genetic engineering, genomics, and related areas

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Editorial Reviews

Doody's Review Service
Reviewer: Ruben Mestril, PhD (Loyola University Medical Center)
Description: This is an excellent survey of the main topics in modern day molecular biology as well as the new and updated topics such as proteomics and molecular evolution, among others. The presentation is clear and straightforward and the accompanying illustrations, also updated, enhance student understanding. A nice feature is the tie-in to relevant Cell Press articles that introduce students to the process of analytical thinking. Each chapter is followed by a section of key concepts, review questions, and conceptual questions, helpful for review.
Purpose: The main purpose is to present a survey of current topics in molecular biology. The interesting chapters on genomics and systems biology (chap. 9), proteomics (chap. 15), and molecular evolution (chap. 26), provide an excellent roadmap to how molecular biology has impacted our understanding of life on earth and possible future applications.
Audience: The book is written primarily for upper-division students interested in the study of molecular biology and genomics. It provides a good primer for first year graduate students, but it also is a good starting point for biological investigators not familiar with the different aspects of modern day molecular biology as well as those who are interested in biotechnology, since this is the required precursor to a second book in this series, Biotechnology, by the same authors.
Features: The book's six units cover general areas of molecular biology: basic chemical and biological principles, the genome, the central dogma of molecular biology, regulating gene expression, subcellular life forms, and changing the DNA blueprint. Each unit has three to six chapters covering topics related to each of these areas of study. Since each unit can be read or studied independently of the other units, this permits instructors as well as students to concentrate on their area of interest. Some of the convenient features include, for example, the accompanying online animations, which help to illustrate important points, and the sections called "Focus on Relevant Research," which are helpful in integrating some of the original literature from Cell Press. In addition, the key concepts, review questions, and conceptual questions are an excellent aid for students to review the material.
Assessment: Overall, this is an excellent textbook for students interested in molecular biology and its potential applications. This second edition is a significant update, with new chapters that address recent advances in molecular biology. The "Focus on Relevant Research" is a welcome new feature that connects the various topics with recent original scientific journal publications. The accompanying online resources are also excellent tools for both students and instructors.
From the Publisher
"This is an excellent book. It is very lucidly written. Clark covers a suitable set of topics, and treats each topic very thoroughly...He is very up-to-date in his coverage of the material."
- John G. Burr, University of Texas at Dallas

"This textbook is very comprehensive, covering nearly all aspects of molecular biology and genetics. The textbook excels in defining key terms in a clear and understable way...The sprinkling of little side stories...keeps the reader interested, and kept me glued throughout the text."
- B. Franklin Pugh, Penn State University

"The author did a very good job covering this vast subject and offered many insightful perspectives."
- John F. Cannon, University of Missouri

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Product Details

  • ISBN-13: 9780123785947
  • Publisher: Elsevier Science
  • Publication date: 2/27/2012
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 928
  • Sales rank: 646,250
  • Product dimensions: 8.80 (w) x 11.10 (h) x 1.50 (d)

Meet the Author

Dr. Clark has taught courses in Molecular Biology and Bacterial Physiology and Biochemistry at Southern Illinois University since 1981.
Research into the Regulation of Alcohol Fermentation in E. coli has been funded by the U.S. Department of Energy, Office of Basic Energy Sciences from 1982 till present.
Supervised 11 master’s and 7 PhD students
Published approximately 70 articles in scientific journals
Previously published work includes "Molecular Biology Made Simple and Fun" coauthored with Lonnie Russell. (Cache River Press, Vienna, IL, First edition, 1997 and Second edition, 2000)
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Table of Contents

Ch. 1 Basic genetics 1
Ch. 2 Cells and organisms 21
Ch. 3 DNA, RNA and protein 51
Ch. 4 Genes, genomes and DNA 75
Ch. 5 Cell division and DNA replication 103
Ch. 6 Transcription of genes 132
Ch. 7 Protein structure and function 154
Ch. 8 Protein synthesis 197
Ch. 9 Regulation of transcription in prokaryotes 234
Ch. 10 Regulation of transcription in eukaryotes 262
Ch. 11 Regulation at the RNA level 281
Ch. 12 Processing of RNA 302
Ch. 13 Mutations 333
Ch. 14 Recombination and repair 368
Ch. 15 Mobile DNA 396
Ch. 16 Plasmids 425
Ch. 17 Viruses 453
Ch. 18 Bacterial genetics 484
Ch. 19 Diversity of lower eukaryotes 508
Ch. 20 Molecular evolution 533
Ch. 21 Nucleic acids : isolation, purification, detection, and hybridization 567
Ch. 22 Recombinant DNA technology 599
Ch. 23 The polymerase chain reaction 634
Ch. 24 Genomics and DNA sequencing 662
Ch. 25 Analysis of gene expression 693
Ch. 26 Proteomics : the global analysis of proteins 717
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