Molecular Biology for Oncologists / Edition 2

Molecular Biology for Oncologists / Edition 2

by McMillan, T.J. (University of Lancaster), M. Stratton, J. Yarnold
     
 

ISBN-10: 0412712709

ISBN-13: 9780412712708

Pub. Date: 01/28/1996

Publisher: Taylor & Francis

This volume explains how molecular biology is providing insights into the way cell behaviour is subverted in common human cancers. It also shows how the manipulation of genetic material in cells and organisms is improving the understanding and effectiveness of radiation and drug actions.

Overview

This volume explains how molecular biology is providing insights into the way cell behaviour is subverted in common human cancers. It also shows how the manipulation of genetic material in cells and organisms is improving the understanding and effectiveness of radiation and drug actions.

Product Details

ISBN-13:
9780412712708
Publisher:
Taylor & Francis
Publication date:
01/28/1996
Edition description:
2ND
Pages:
368
Product dimensions:
9.21(w) x 6.14(h) x 0.88(d)

Table of Contents

What is molecular biology? How does it relate to cell biology and biochemistry. Cancer genetics. What are cancer genes? How are cancer genes mutated? Hereditary predisposition and gene discovery. Important chromosomal translocations in cancer. Signal transduction and cancer. GTP-binding proteins and cancer. Cell cycle controls and cancer. Viruses and human cancer. Cell adhesion, motility and cancer. Differentiation and cancer. Multistage carcinogenesis. Chromatin structure and nuclear function. Genomic instability and cancer. Strategies for cancer prevention and cure. Opportunities for genetic counselling. Molecular basis of radiation sensitivity. How do cells repair DNA damage by radiation? Radiation-induced cytokines and growth factors. Chemotherapeutic drug-induced DNA damage and repair. Molecular basis of drug resistance. Drug discovery and cancer genetics. The molecular biology of endocrine responsiveness in breast cancer. Apoptosis as a therapeutic target. Tumour angiogenesis as a therapeutic target. Antibody technology is being transformed. Strategies for gene therapy of cancer. Prodrug therapies. Oligonucleotide therapies.

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