Molecular Biology for Oncologists / Edition 2

Molecular Biology for Oncologists / Edition 2

by McMillan, T.J. (University of Lancaster), M. Stratton, J. Yarnold
     
 

ISBN-10: 0412712709

ISBN-13: 9780412712708

Pub. Date: 01/28/1996

Publisher: Taylor & Francis

This volume explains how molecular biology is providing insights into the way cell behaviour is subverted in common human cancers. It also shows how the manipulation of genetic material in cells and organisms is improving the understanding and effectiveness of radiation and drug actions.  See more details below

Overview

This volume explains how molecular biology is providing insights into the way cell behaviour is subverted in common human cancers. It also shows how the manipulation of genetic material in cells and organisms is improving the understanding and effectiveness of radiation and drug actions.

Product Details

ISBN-13:
9780412712708
Publisher:
Taylor & Francis
Publication date:
01/28/1996
Edition description:
2ND
Pages:
368
Product dimensions:
9.21(w) x 6.14(h) x 0.88(d)

Table of Contents

List of contributors
Foreword
Preface
What are cancer genes and how do they upset cell behaviour?3
Mechanisms of activation and inactivation of dominant oncogenes and tumour suppressor genes16
Hereditary predisposition and gene discovery27
Chromosomal translocations in cancer38
Signal transduction and cancer45
G proteins, Ras and cancer63
Cell cycle control and cancer75
Human papillomaviruses and cancer of the cervix83
The p53 gene in human cancer92
Cell adhesion, motility and cancer103
Differentiation and cancer112
Multistage carcinogenesis122
Genomic instability and cancer134
Inherited predispositions to cancer: opportunities for genetic counselling155
Molecular basis of radiation sensitivity166
How do cells repair DNA damage caused by ionizing radiation?176
Chemotherapeutic drug-induced DNA damage and repair185
Molecular basis of drug resistance198
Drug discovery and cancer genetics208
The molecular biology of endocrine responsiveness in breast cancer217
Apoptosis as a therapeutic target230
Tumour angiogenesis as a therapeutic target240
Antibody technology has been transformed250
Current and future aspects of gene therapy for cancer261
Directed enzyme prodrug therapies: ADEPT and GDEPT269
Oligonucleotide therapies275
Introduction to gene structure and expression295
Chromatin structure and nuclear function303
The PCR revolution316
Techniques of molecular biology322
Glossary332
Index343

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