Molecular Biology for Oncologists / Edition 2

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The pathophysiology, cell proliferation kinetics and metastasis of cancers and their responses to the currently employed therapies are increasingly being understood in terms of their genetic control mechanisms. Parallel genetic investigations are being aggressively pursued for normal tissue systems. The resultant greatly enhanced understanding is leading to clinically useful predictors of prognosis and the beginnings of new therapeutic strategies so as to augment the differential effect on tumour and normal tissues. This includes not only manoeuvres which deploy the currently available treatment methods with greater effect, but also the intro­ duction into the clinic of conceptually different treatment strategies, with the potential of great positive impact. Development in the field of basic genetics of cancer biology, cell cycle control, angiogenesis, immunology, etc. have been extraordinarily rapid with exceptional importance to medicine. This area has attracted some of the keenest intellects and greatest enthusiasm in biology and medicine. To illustrate the vigour and the growth rate of the research activity in this area, note that the numbers of journal articles published with the words gene and cancer (carcinoma, sarcoma, neoplasm, tumour) in the title or abstract for 1975 was 14 and for 1995 was 14 593. This number has increased dramatically over the past two decades. The entire field of oncology (clinical and laboratory) has, likewise, been growing at a remarkable pace.

"...explains how new techniques involving the manipulation of genetic material in cells & organisms are providing dramatic insights into how cell behavior is subverted in common human cancers."

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Product Details

  • ISBN-13: 9780412712708
  • Publisher: Taylor & Francis
  • Publication date: 1/28/1996
  • Edition description: 2ND
  • Edition number: 2
  • Pages: 368
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

List of contributors
What are cancer genes and how do they upset cell behaviour? 3
Mechanisms of activation and inactivation of dominant oncogenes and tumour suppressor genes 16
Hereditary predisposition and gene discovery 27
Chromosomal translocations in cancer 38
Signal transduction and cancer 45
G proteins, Ras and cancer 63
Cell cycle control and cancer 75
Human papillomaviruses and cancer of the cervix 83
The p53 gene in human cancer 92
Cell adhesion, motility and cancer 103
Differentiation and cancer 112
Multistage carcinogenesis 122
Genomic instability and cancer 134
Inherited predispositions to cancer: opportunities for genetic counselling 155
Molecular basis of radiation sensitivity 166
How do cells repair DNA damage caused by ionizing radiation? 176
Chemotherapeutic drug-induced DNA damage and repair 185
Molecular basis of drug resistance 198
Drug discovery and cancer genetics 208
The molecular biology of endocrine responsiveness in breast cancer 217
Apoptosis as a therapeutic target 230
Tumour angiogenesis as a therapeutic target 240
Antibody technology has been transformed 250
Current and future aspects of gene therapy for cancer 261
Directed enzyme prodrug therapies: ADEPT and GDEPT 269
Oligonucleotide therapies 275
Introduction to gene structure and expression 295
Chromatin structure and nuclear function 303
The PCR revolution 316
Techniques of molecular biology 322
Glossary 332
Index 343
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