Molecular Biology for Oncologists / Edition 2

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Overview

This volume explains how molecular biology is providing insights into the way cell behaviour is subverted in common human cancers. It also shows how the manipulation of genetic material in cells and organisms is improving the understanding and effectiveness of radiation and drug actions.

"...explains how new techniques involving the manipulation of genetic material in cells & organisms are providing dramatic insights into how cell behavior is subverted in common human cancers."

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Product Details

  • ISBN-13: 9780412712708
  • Publisher: Taylor & Francis
  • Publication date: 1/28/1996
  • Edition description: 2ND
  • Edition number: 2
  • Pages: 368
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

List of contributors
Foreword
Preface
What are cancer genes and how do they upset cell behaviour? 3
Mechanisms of activation and inactivation of dominant oncogenes and tumour suppressor genes 16
Hereditary predisposition and gene discovery 27
Chromosomal translocations in cancer 38
Signal transduction and cancer 45
G proteins, Ras and cancer 63
Cell cycle control and cancer 75
Human papillomaviruses and cancer of the cervix 83
The p53 gene in human cancer 92
Cell adhesion, motility and cancer 103
Differentiation and cancer 112
Multistage carcinogenesis 122
Genomic instability and cancer 134
Inherited predispositions to cancer: opportunities for genetic counselling 155
Molecular basis of radiation sensitivity 166
How do cells repair DNA damage caused by ionizing radiation? 176
Chemotherapeutic drug-induced DNA damage and repair 185
Molecular basis of drug resistance 198
Drug discovery and cancer genetics 208
The molecular biology of endocrine responsiveness in breast cancer 217
Apoptosis as a therapeutic target 230
Tumour angiogenesis as a therapeutic target 240
Antibody technology has been transformed 250
Current and future aspects of gene therapy for cancer 261
Directed enzyme prodrug therapies: ADEPT and GDEPT 269
Oligonucleotide therapies 275
Introduction to gene structure and expression 295
Chromatin structure and nuclear function 303
The PCR revolution 316
Techniques of molecular biology 322
Glossary 332
Index 343
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