Molecular Biology in Cellular Pathology / Edition 1

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Molecular biology has had a major impact on the practice of pathology in recent years and this continues with the new approaches being developed in genomics and proteomics. Knowledge of the molecular organization of the cell has led to the development of powerful new techniques which bring greater accuracy and objectivity to the diagnosis, prognosis and management of many diseases, and to the study of pathological states. This book is a completely revised and updated version of the popular Molecular Biology in Histopathology, with added material covering the latest methodologies and now featuring colour plates. It describes the molecular techniques available and provides an overview of how they can be applied. It is aimed at histopathologists in training, clinicians and biologists studying for post-graduate qualifications and will also be of interest to biochemists, physiologists, pharmacologists and biotechnologists, in academia, clinical medicine and industry.
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Product Details

  • ISBN-13: 9780470844755
  • Publisher: Wiley
  • Publication date: 5/23/2003
  • Edition description: Subsequent
  • Edition number: 1
  • Pages: 400
  • Product dimensions: 7.03 (w) x 9.78 (h) x 1.18 (d)

Table of Contents

Preface to Molecular Biology in Histopathology
List of Contributors
1 Blotting Techniques: Methodology and Applications 1
2 In-situ Hybridisation in Histopathology 19
3 DNA Flow Cytometry 49
4 Interphase Cytogenetics 61
5 Oncogenes 79
6 Molecular and Immunological Aspects of Cell Proliferation 105
7 Interphase Nucleolar Organiser Regions in Tumour Pathology 137
8 Apoptosis and Cell Senescence 153
9 The Polymerase Chain Reaction 193
10 Laser Capture Microdissection: Technique and Applications in the Molecular Analysis of the Cancer Cell 213
11 The In-situ Polymerase Chain Reaction 233
12 TaqMan Technology and Real-Time Polymerase Chain Reaction 251
13 Gene Expression Analysis Using Microarrays 269
14 Comparative Genomic Hybridisation in Pathology 287
15 DNA Sequencing and the Human Genome Project 307
16 Monoclonal Antibodies: The Generation and Application of 'Tools of the Trade' Within Biomedical Science 329
17 Proteomics 351
Index 371
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