Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics / Edition 2

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics / Edition 2

by Lauren Pecorino
     
 

ISBN-10: 0199211485

ISBN-13: 9780199211487

Pub. Date: 05/06/2008

Publisher: Oxford University Press, USA

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics presents a fresh approach to the study of the molecular basis of cancer. Shows how an understanding of the molecular processes underpinning cancer can be directly applied to the development of new therapeutics, giving students a clear appreciation of how the theory translates to tackling the

Overview

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics presents a fresh approach to the study of the molecular basis of cancer. Shows how an understanding of the molecular processes underpinning cancer can be directly applied to the development of new therapeutics, giving students a clear appreciation of how the theory translates to tackling the disease, Provides a carefully structured overview of the molecular mechanisms that regulate cell growth, and relates defects in these mechanisms to the onset of cancer, so that students can clearly see the link between the two, Draws on the latest research in this dynamic field and presents it with a unique clarity, making cutting-edge science readily accessible to students.

Product Details

ISBN-13:
9780199211487
Publisher:
Oxford University Press, USA
Publication date:
05/06/2008
Edition description:
Older Edition
Pages:
320
Product dimensions:
7.40(w) x 9.60(h) x 0.60(d)

Table of Contents

Preface vii

Acknowledgments xi

1 Introduction 1

1.1 What is cancer? 2

1.2 Evidence suggests that cancer is a genetic disease at the cellular level 4

1.3 Influential factors in human carcinogenesis 9

1.4 Principles of conventional cancer therapies 12

1.5 Clinical trials 14

1.6 The role of molecular targets in cancer therapies 15

2 DNA structure and stability: mutations versus repair 21

2.1 Gene structure-two parts of a gene: the regulatory region and the coding region 22

2.2 Mutations 23

2.3 Carcinogenic agents 24

2.4 DNA repair and predispositions to cancer 36

Therapeutic strategies 39

2.5 Conventional therapies: chemotherapy and radiation therapy 39

3 Regulation of gene expression 47

3.1 Transcription factors and transcriptional regulation 47

3.2 Chromatin structure 54

3.3 Epigenetic regulation of transcription 55

3.4 Evidence of a role for epigenetics in carcinogenesis 58

3.5 Telomeres and telomerase 60

Therapeutic strategies 64

3.6 Epigenomic and histonomic drugs 64

3.7 Telomerase inhibitors 65

4 Growth factor signaling and oncogenes 69

4.1 Epidermal growth factor signaling: an important paradigm 70

4.2 Oncogenes 78

Therapeutic strategies 86

4.3 Kinase inhibitors 87

4.4 RAS-directed therapies 91

5 The cell cycle 95

5.1 Cyclins and cyclin-dependent kinases (cdks) 96

5.2 Mechanisms of cdk regulation 99

5.3 Progression through the G[subscript 1] checkpoint 101

5.4 The G[subscript 2] checkpoint 103

5.5 The mitotic checkpoint 104

5.6 The cell cycle and cancer 106

Therapeutic strategies 108

5.7 Cyclin-dependent kinase inhibitors 109

5.8 Other cell cycle kinase targets 109

5.9 Inhibitors of themitotic spindle 110

6 Growth inhibition and tumor suppressor genes 113

6.1 Definitions of tumor suppressor genes 113

6.2 The retinoblastoma gene 117

6.3 Mutations in the RB pathway and cancer 118

6.4 The p53 pathway 119

6.5 Mutations in the p53 pathway and cancer 127

6.6 Interaction of DNA viral protein products with RB and p53 129

Therapeutic strategies 130

6.7 Targeting of the p53 pathway 130

7 Apoptosis 137

7.1 Molecular mechanisms of apoptosis 139

7.2 Apoptosis and cancer 148

7.3 Apoptosis and chemotherapy 152

Therapeutic strategies 154

7.4 Apoptotic drugs 154

8 Stem cells and differentiation 161

8.1 Stem cells and cancer 162

8.2 Differentiation and the regulation of transcription 171

Therapeutic strategies 176

8.3 Inhibitors of the Wnt pathway 177

8.4 Inhibitors of the Hh pathway 178

8.5 Leukemia and differentiation therapies 180

9 Metastasis 185

9.1 Steps of metastasis 186

9.2 Tools of cell migration: cell adhesion molecules, integrins, and proteases 186

9.3 Intravasation 189

9.4 Transport 191

9.5 Extravasation 191

9.6 Metastatic colonization 192

9.7 The angiogenic switch 194

9.8 Parallels between early development and metastasis 199

9.9 Other means of tumor neovascularization 200

Therapeutic strategies 201

9.10 Metalloproteinase inhibitors (MPIs) 201

9.11 Anti-angiogenic therapy and vascular targeting 202

9.12 Targeting several steps of metastasis at once 207

10 Infections and inflammation 211

10.1 Identifying infectious agents as carcinogens 212

10.2 Inflammation and cancer 217

Therapeutic strategies 223

10.3 A national vaccination program against Hepatitis B virus in Taiwan 224

10.4 Eradication of H. pylori and the relationship to prevention of gastric cancer 225

10.5 Cancer vaccines to prevent cervical cancer 225

10.6 Inhibition of inflammation 227

11 Nutrients, hormones, and gene interactions 231

11.1 Causative factors 233

11.2 Preventative factors: microconstituents of fruits and vegetables 237

11.3 Metabolic changes in tumor cells 242

11.4 Genetic polymorphisms and diet 244

11.5 Vitamin D: a link between nutrients and hormone action 245

11.6 Hormones and cancer 247

Therapeutic strategies 251

11.7 'Enhanced' foods and dietary supplements for chemoprevention 251

11.8 Drugs that target energy pathways 252

11.9 Drugs that target estrogen 252

12 The cancer industry: drug development and clinical trial design 259

12.1 Strategies of drug development 259

12.2 Development of imatinib 263

12.3 Second-generation therapeutics 265

12.4 Pharmacogenomics 266

12.5 Improved clinical trial design 267

12.6 A career in cancer research 270

13 Cancer in the future: focus on diagnostics and immunotherapy 275

13.1 Cancer vaccines 276

13.2 Microarrays and expression profiling 283

13.3 Diagnostics and prognostics 285

13.4 Imaging 287

13.5 Cancer research bioinformatics 288

13.6 Cancer nanotechnology 289

13.7 Treating cancer symptoms 291

13.8 Are we making progress? 291

Appendix 1 Cell Cycle Regulation 297

Appendix 2 Centers for Cancer Research 298

Glossary 302

Index 311

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