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Molecular Biology of Cardiovascular Diseases

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This timely resource offers up-to-the-minute coverage of basic science and important clinical advances as well as future challenges and opportunities in the application of molecular and cellular biology to cardiovascular diseases.

The book contains black-and-white illustrations.

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Overview

This timely resource offers up-to-the-minute coverage of basic science and important clinical advances as well as future challenges and opportunities in the application of molecular and cellular biology to cardiovascular diseases.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Allen Mark Samarel, MD (Loyola University Stritch School of Medicine)
Description: This multiauthored text edited by two internationally renowned experts in cardiovascular molecular biology consists of three major parts. The first part is a primer of molecular biology for the cardiovascular specialist. The second part focuses on transmembrane signaling in cells of the cardiovascular system. The third part addresses specific topics in the field of vascular biology and the regulation of cellular growth.
Purpose: The editors have assembled contributions from 33 different authors with the hope of providing a thoughtful, forward-looking summary of exciting discoveries in cardiovascular research. This is a very worthy objective, because there are few available resource books in this rapidly growing field.
Audience: The editors hope to provide a basic text targeted to cardiology students, fellows, and practicing clinicians, but they also hope that the volume will provide pertinent summaries for experts in the specific fields of interest.
Features: The book features outstanding contributions by leaders in the fields of signal transduction, the structure and function of ion channels, and the molecular biology of congenital cardiovascular diseases. Individual chapters are usually well referenced and up-to-date. Illustrations are informative and well presented.
Assessment: The book has many strengths, but it suffers somewhat from an overall lack of focus. It seems that the editors have tried to accomplish too much. In their attempt to be inclusive, parts of the book may be irrelevant to their target audience. In addition, other areas have been omitted. For instance, an entire chapter is devoted to direct gene injection into the myocardium, but the use of adenoviral and other gene delivery methods is largely ignored. This lack of focus detracts from other excellent contributions in cell signaling and the molecular biology of ion channels, either of which could be the major focus of a text of this size.
Clinical and Applied Thrombosis/Hemostasis
Competing with the excitement generated by risk management and interventional cardiology, the Molecular Biology of Cardiovascular Disease is now gathering the attention of young cardioloigsts, hematologists, and those in training to better understand vascular biology, ion channels, cell growth, and signaling.... ...bridge[s] the substantial gap between the limited educational resources available only a few years ago and the cutting edge of modern understanding that extends beyond inquiry, examination, imaging, and pharmacology.
Bulletin of the British Society for Cardiovascular Research
...a thoroughly good read, very well laid out, educational and stimulating.
Allen M. Samarel
This multiauthored text edited by two internationally renowned experts in cardiovascular molecular biology consists of three major parts. The first part is a primer of molecular biology for the cardiovascular specialist. The second part focuses on transmembrane signaling in cells of the cardiovascular system. The third part addresses specific topics in the field of vascular biology and the regulation of cellular growth. The editors have assembled contributions from 33 different authors with the hope of providing a thoughtful, forward-looking summary of exciting discoveries in cardiovascular research. This is a very worthy objective, because there are few available resource books in this rapidly growing field. The editors hope to provide a basic text targeted to cardiology students, fellows, and practicing clinicians, but they also hope that the volume will provide pertinent summaries for experts in the specific fields of interest. The book features outstanding contributions by leaders in the fields of signal transduction, the structure and function of ion channels, and the molecular biology of congenital cardiovascular diseases. Individual chapters are usually well referenced and up-to-date. Illustrations are informative and well presented. The book has many strengths, but it suffers somewhat from an overall lack of focus. It seems that the editors have tried to accomplish too much. In their attempt to be inclusive, parts of the book may be irrelevant to their target audience. In addition, other areas have been omitted. For instance, an entire chapter is devoted to direct gene injection into the myocardium, but the use of adenoviral and other gene delivery methods is largelyignored. This lack of focus detracts from other excellent contributions in cell signaling and the molecular biology of ion channels, either of which could be the major focus of a text of this size.
Booknews
Twenty-one contributions provide an introduction to the power and breadth of molecular and cellular biology as it applies to the cardiovascular system, with discussion of vascular biology, ion channels, cell growth, and signalling. Arrangement is in sections on methodology and techniques, transmembrane signaling, and signalling in disease states. Coverage includes the basics of the field, as well as clinically relevant questions and discussion of the challenges and opportunities for advances in the next five to ten years. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824794057
  • Publisher: Taylor & Francis
  • Publication date: 2/20/1997
  • Series: Fundamental and Clinical Cardiology Series , #30
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 560
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.00 (d)

Table of Contents

Overview of Methodology and Introduction to Techniques

DNA and RNA, Loewe O. Go Cloning and Expression, Andrew R. Marks Expression Cloning and Screening for Unknown Genes, Mark E. Lieb Gene Transfer into Adult Cardiac Myocytes in Vivo by Direct Injection of DNA, Koji Hasegawa and Richard N. Kitsis Studies of Cardiac Myocytes in Culture: A Developmental Perspective, D. Stave Kohtz Congenital Heart Disease: Gene Defects and Molecular Biological Studies, Bruce D. Gelb

Transmembrane Signaling

Molecular Biology of Nitric Oxide Synthases, Thomas Michel, Santiago Lamas, and Kazuhiro Sase Signaling Through Heterotrimeric G Proteins, Yibang Chen, Anya Harry, and Ravi Iyengar Molecular Physiology of Cardiac Sodium Channels, Sarah K. England and Michael M. Tamkun Molecular Properties of Cardiac Potassium Channels in Health and Disease, Marie-Noelle S. Langan and Diomedes E. Logothetis Plasma membrane Calcium Channels, Andrew R. Marks Structure and Function of Calcium Release Channels, Andrew R. Marks Advances in the Molecular Characterization of the Na+/Ca2+ Exchanger, Dan H. Schulze and W. J. Lederer

Signaling in Disease States

Tyrosine Kinases in the Regulation of Vascular Smooth Muscle Function, Marshall A. Corson and Bradford C. Berk Myocardial Growth Factors, W. Robb MacLellan, James Hawker, and Michael D. Schneider Gene Therapy and the Vessel Wall, Jonathan D. Marmur The Extracellular Matrix and Smooth Muscle Cell Migration, Andrea S. Weintraub and Mark B. Taubman Microfibril Pathology and Cardiovascular Manifestations in Marfan Syndrome, Lygia V. Pereira, Hui Zhang, and Francesco Ramirez The Role of Tissue Factor in Arterial Thrombosis and Atherosclerosis, Mark B. Taubman Regulation of the Production of Lipoproteins Containing Apolipoprotein B, Edward A. Fisher Platelets and Cardiovascular Disease, Christine M. Grimaldi and Deborah L. French

Glossary

Appendix: Genetic Cardiovascular Disease

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