Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion / Edition 1

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Overview

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

This book contains black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: Kevan C. Herold, MD (Columbia University College of Physicians and Surgeons)
Description: This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable.
Purpose: The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes.
Audience: The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date.
Features: In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified.
Assessment: This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful.
From The Critics
Reviewer: Kevan C. Herold, MD(Columbia University College of Physicians and Surgeons)
Description: This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable.
Purpose: The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes.
Audience: The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date.
Features: In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified.
Assessment: This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful.
Kevan C. Herold
This is the first of a new two-part series designed to review the latest in diabetes research in a comprehensive but concise manner. In this volume, the authors have invited contributions pertaining to factors affecting beta cell function, including autoimmunity, the genetics of diabetes, and molecular mechanisms of insulin synthesis and secretion. Because the field has evolved rapidly, a concise summary of the latest developments is very valuable. The book is written primarily for researchers and others with particular interests in the pathogenesis of diabetes. However, there is a great deal of valuable information for specialists in diabetes that has bearing on approaches to disease and future treatment. The text is not overly bogged down with experimental details, and so it would also be valuable to one interested in keeping abreast of research developments in the field. The authors and contributors are recognized authorities in the field of diabetes. The book is easy to read, but there are relatively few illustrations. Those that are included deal primarily with presentation of data rather than summary of concepts. The references are, in general, up-to-date. In general, the book includes broadly based reviews of essential areas. Overall, the chapters are well written. However, they do tend to focus on the author's own biases, and a more balanced approach would improve the quality of the book. However, this is also a strength of this book. Each of the contributors is an outstanding researcher in the field, and has made significant contributions. Thus, the approaches taken are justified. This is an essential book for a medical library to have, and it is a welcome addition to thelibrary of investigators in the field. Specialists in diabetes will also find this book very useful.
Booknews
The first of two volumes comprising a comprehensive survey and synthesis of current knowledge on the molecular biology of diabetes and insulin action. Part I focuses exclusively on the genetic basis of diabetes and the molecular biology of insulin synthesis, secretion, and regulation. The topics include pathogenesis of autoimmune diabetes, gene structure and regulation of insulin, and glucose toxicity and the insulin gene. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896032866
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/2/1994
  • Edition description: 1995
  • Edition number: 1
  • Pages: 404
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.94 (d)

Table of Contents

Section I: Molecular Mechanisms of Autoimmunity and Genetics of Diabetes. Molecular Targets of the Autoimmunity of Type I Diabetes. Murine Transgenic Models of IDDM. Pancreatic Islet Transplantation. Pathogenesis of Autoimmune Diabetes. Section II: Molecular and Cellular Aspects of Insulin Synthesis and Secretion. Insulin Gene Structure and Regulation. Molecular Engineering of Glucose-Regulated Insulin Secretion. Glucokinase Gene Expression and Regulation. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A- and B-Cells. Glucose Toxicity and the Insulin Gene. Proinsulin-Processing Endopeptidases. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis. Beta Cell Receptors: Mechanisms of Signal Transduction. Molecular Biology of the Ion Channels in the Pancreatic b-Cell. Molecular Biology of Gap-Junction Proteins. The Gluco-Incretin Hormone Glucagon-Like Peptide-1 and Its b-Cell Receptor. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion. Index.

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