Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion / Edition 1

Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion / Edition 1

by Boris Draznin
     
 

ISBN-10: 0896032868

ISBN-13: 9780896032866

Pub. Date: 09/02/1994

Publisher: Springer-Verlag New York, LLC

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated

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Overview

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

Product Details

ISBN-13:
9780896032866
Publisher:
Springer-Verlag New York, LLC
Publication date:
09/02/1994
Edition description:
1994
Pages:
404
Product dimensions:
5.98(w) x 9.02(h) x 0.04(d)

Table of Contents

Section I: Molecular Mechanisms of Autoimmunity and Genetics of Diabetes. Molecular Targets of the Autoimmunity of Type I Diabetes. Murine Transgenic Models of IDDM. Pancreatic Islet Transplantation. Pathogenesis of Autoimmune Diabetes. Section II: Molecular and Cellular Aspects of Insulin Synthesis and Secretion. Insulin Gene Structure and Regulation. Molecular Engineering of Glucose-Regulated Insulin Secretion. Glucokinase Gene Expression and Regulation. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A- and B-Cells. Glucose Toxicity and the Insulin Gene. Proinsulin-Processing Endopeptidases. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis. Beta Cell Receptors: Mechanisms of Signal Transduction. Molecular Biology of the Ion Channels in the Pancreatic b-Cell. Molecular Biology of Gap-Junction Proteins. The Gluco-Incretin Hormone Glucagon-Like Peptide-1 and Its b-Cell Receptor. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion. Index.

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