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Protozoans are interesting creatures for several reasons, not least of which is their ability to live inside or among the cells of their hos t while resisting the host's cellular defences. The rigours of their l ifestyle have resulted in the evolution of some remarkable adaptation at the biochemical level; many parasites have dispensed with entire me tabolic pathways, and have evolved complex mechanisms for transmission to new hosts. Parasitic protozoa cause some of the major infectious d iseases of humans and domestic animals. In recent years, new molecular biological techniques have opened up the study of the biology of thes e parasites, and tremendous advances have been made. This book covers this interesting and fast-moving field at an advanced level for which there is no other up-to-date book.
The book contains black-and-white illustrations.
1. Trypanosomatid genetics
2. The three genomes of Plasmodium
3. Toxoplasma as a model genetic system
4. Kinetoplast DNA: structure and replication
5. Developmental regulation of gene expression in African trypanosomes
6. Trans-splicing in trypanosomatid protozoa
7. RNA editing. Post-transcriptional restructuring of genetic information
8. Biogenesis of specialized organelles: glycosomes and hydrogenosomes
9. Mechanism of drug resistance in protozoan parasites
10. Glycosyl-phosphatidylinositols and the surface architecture of parasitic protozoa