Molecular Biology of RNA / Edition 1

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Overview


For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA in the evolution of life itself.

Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles as catalysts and regulatory molecules.

Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment.

Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever.

Online Resource Centre
The Online Resource Centre to accompany Molecular Biology of RNA features:

For registered adopters:
Figures from the book in electronic format

For students:
A hyperlinked bibliography of literature articles cited in the text

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Editorial Reviews

From the Publisher

"All aspects of RNA biology are described clearly... One type of molecule, one book, up to date... A book on RNA like this is just in time. " - Dr. J. Kooter, Vrije Universiteit Amsterdam

"There are currently no suitable textbooks (on Molecular Biology of RNA) that I am aware of, and thus this book fills a very useful niche. " - Dr. S. Valadkhan, Case Western Reserve University

Molecular Biology of RNA was featured in The Quarterly Review of Biology.

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Product Details

  • ISBN-13: 9780199288373
  • Publisher: Oxford University Press, USA
  • Publication date: 2/2/2011
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 460
  • Sales rank: 1,437,451
  • Product dimensions: 7.60 (w) x 10.40 (h) x 0.80 (d)

Meet the Author

David Elliott is a Reader in Genetics at the Institute of Human Genetics, Newcastle University, UK
Michael Ladomery is Principal Investigator in the RNA Biology group, School of Life Sciences, University of the West of England, UK.

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Table of Contents

1. Introduction: what is post-transcriptional gene regulation?
2. The versatility of RNA structure
3. RNA catalysis
4. The RNA binding proteins
5. Capping, cleavage and nuclear polyadenylation
6. Pre-mRNA splicing- Part 1, nuts and bolts
7. Pre-mRNA splicing- Part 2, the central role of introns and splicing in eukaryotic gene expression
8. Regulated RNA processing- How pre-mRNAs are decoded by the splicing machinery
9. Regulated RNA processing- Alternative splicing
10. pre-mRNA processing in development and disease
11. Nucleocytoplasmic traffic of mRNAs
12. Nucleocytoplasmic traffic of noncoding RNAs
13. mRNA localisation
14. mRNA translation
15. mRNA stability and decay
16. rRNA and tRNA processing
17. RNA Editing
18. RNA interference and microRNAs
19. Long non-coding RNAs
20. RNA techniques

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