Molecular Biophysics of the Extracellular Matrix / Edition 1

Molecular Biophysics of the Extracellular Matrix / Edition 1

ISBN-10:
0896030512
ISBN-13:
9780896030510
Pub. Date:
10/19/1984
Publisher:
Springer-Verlag New York, LLC
ISBN-10:
0896030512
ISBN-13:
9780896030510
Pub. Date:
10/19/1984
Publisher:
Springer-Verlag New York, LLC
Molecular Biophysics of the Extracellular Matrix / Edition 1

Molecular Biophysics of the Extracellular Matrix / Edition 1

Hardcover

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Product Details

ISBN-13: 9780896030510
Publisher: Springer-Verlag New York, LLC
Publication date: 10/19/1984
Series: Molecular Biology and Biophysics Series
Edition description: 1984
Pages: 189
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

1 Structure and Associations of Proteoglycans in Cartilage.- Structure.- Preparation.- Link-Free Aggregates.- Link-Stable Aggregates.- The Secretion and Assembly of Proteoglycan Aggregates.- Diversity of Proteoglycan Structure.- 2 The Dilute Solution Properties of Glycosaminoglycans and Proteoglycans.- The Relevance of the Term “Dilute Solution”.- Hyaluronate.- The Sulfated Glycosaminoglycans.- Proteoglycans.- Conclusions.- 3 X-Ray Diffraction Analyses of Glycosaminoglycans.- The Relevance of Fiber Diffraction Studies.- Accuracy and Precision in Fiber Diffraction Analyses.- Polymorphism of Glycosaminoglycan Helices.- Detailed Structural Studies of Hyaluronate Allomorphs.- Detailed Structural Studies of Chondroitin Sulfate Allomorphs.- Detailed Structural Studies of Dermatan Sulfate Allomorphs.- The Roles of Cations in Conformation and Packing.- Proteoglycans and Heterotypic Interactions.- Conclusions.- 4 Conformation of Individual Residues and Chain Segments of Glycosaminoglycans in Solution by Spectroscopic Methods.- Conformation of Individual Residues.- Conformation of Chain Segments.- 5 Self-Association of Copolymeric Glycosaminoglycans (Proteoglycans).- Dermatan Sulfate.- Affinity Chromatography.- Gel Chromatography.- Light Scattering.- Chemistry.- Heparan Sulfate.- Gel Chromatography.- Light Scattering.- Chemistry.- Proteodermatan Sulfate.- Extraction and Purification.- Characterization.- Characterization of the Proteoglycan Subfractions.- Self-Association of Scleral Proteoglycans.- 6 Transport of Molecules in Connective Tissue Polysaccharide Solutions.- The State of Polysaccharides in Connective Tissue.- Modes of Transport.- Diffusion in a Binary System.- Diffusional Transport Within a Homogeneous Polymer Matrix.- Transport Across a Matrix (or Membrane).- Transport in an Inhomogeneous Matrix.- Interpretation of Translational Transport Data.- Diffusion of Low Molecular Weight Solutes in Polymer Matrices—Concept of Microviscosity.- Mutual Diffusion of Macromolecular Solutes in a Binary System.- Diffusion of Macromolecular Solutes in Matrices.- Summarizing View.- Rotational Diffusion.- Transport of Electrolytes.- Simple Electrolytes.- Polyelectrolytes.- Formation and Transport of Matrix Structures.- Observation of Very Rapid Polymer Transport in Concentrated Ternary Systems.- Visualization of the Anomalous Transport.- A Tentative Explanation of the Phenomenon.- Biological Implications.- 7 Glycosaminoglycan Chains in the Biological State.- Introduction—Molecular Species.- Molecular Shapes.- Molecular Assemblies.- References.
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