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Doody's Review ServiceReviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This text deals with the new language of biology, molecular structure, physiology of the normal heart, cardiac and vascular remodeling, genetics for the non-geneticist, gene therapy, and cell transplantation.
Purpose: The purpose is to make available a short, well-written summary of what cellular molecular biology brings to cardiology. It is an important objective since many cardiologists are trained in anatomy and physiology. The book is well written.
Audience: It is intended for clinicians and primary care physicians and deals with the knowledge explosion in the cellular molecular cardiac area in the past five years or so.
Features: The book begins with definitions from mitosis and cell division to the genetic code in the Human Genome Project. The basic tools of molecular biology such as probes and oligonucleotides, restriction enzymes, and the polymerase chain reaction are described. There are many excellent tables listing membrane protein families as well as ion channels and other important areas. The text is well illustrated with black-and-white drawings so the reader can follow the text with the help of the illustrations. There is a discussion of the genetics of hyperlipidemia and a brief discussion of the use of gene therapy. An important section is a glossary of terms.
Assessment: This second edition is certainly worthwhile in an area that is showing such rapid development. The text represents an opportunity for clinical cardiologists to drill down to the cellular molecular area where their previous experience in education has been based on anatomy and hemodynamics. It is a worthwhile addition to the cardiac literature.