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Doody's Review ServiceReviewer: Patricia Wong, MD (Stanford University Medical Center)
Description: This is an outstanding reference that thoroughly explains dysfunctional molecular pathways causing the development of skin cancer. Numerous diagrams depict the signaling mechanisms and how mutations in the genes controlling cell kinetics lead to uncontrollable growth and tumors.
Purpose: The purpose is to provide current information on molecular assays for specific genetic mutations and explain how to use this information in determining therapies targeting culprit receptors.
Audience: The audience is dermatologists and any medical care professionals involved in treating patients with skin cancers.
Features: The authors have wonderfully accomplished the task of explaining genetics, DNA synthesis, mutations, and the molecular nuances of disruption leading to potentially lethal tumors and combining this knowledge with practical applications for treating patients. When, why, and who should have these special assays performed is discussed not in an esoteric manner, but in terms of what real dermatologists need to know in making prognostic and therapeutic decisions for their patients.
Assessment: This book is a gem. Every page should be studied. There are no extraneous words. The material discussed is the key to understanding all of dermatology and how to most effectively go down the path to curing melanoma, cutaneous lymphomas, and a host of other potentially fatal diseases.