Molecular Genetics & Gene Therapy of Cardiovascular Diseases

by S. C. Mockrin

Overview

Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases—including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nearly 50 investigators on the cutting-edge of pioneering research in the field.

Product Details

ISBN-13:	9780824794088
Publisher:	Taylor & Francis
Publication date:	01/02/1996
Series:	Fundamental and Clinical Cardiology , #26
Edition description:	New Edition
Pages:	616
Product dimensions:	8.25(w) x 11.00(h) x (d)

Table of Contents

Molecular Genetics and Its Application to Understanding Cardiovascular Disease

Identifying Genes in Humans

A Nonmathematical Overview of Modern Gene Mapping Techniques Applied to Human Diseases

Molecular Genetics of Human Hypertension

Arrythmias and Vascular Disease

Molecular Genetic Studies of Inherited Cardiomyopathies

Hyperlipidemia: Molecular Defects of Apolipoproteins B and E Responsible for Elevated Blood Lipids

Genetic Causes of Aortic Aneurysms

Marfan Syndrome

Genetic Risk Factors for Myocardial Infarction


Using Animals to Dissect Complex Traits

Using Animal Models to Dissect the Genetics of Complex Traits

Genetic Dissection of Hypertension in Experimental Animal Models

Hypertension Research with Genetically Altered Animals

Genetically Altered Mouse Models of Lipoprotein Disorders and Atherosclerosis

Homologous Recombination and Growth Factors

Gene Targeting of Adhesion Molecules in the Vasculature

Cardiogenesis and Molecular Physiology


Gene Transfer and Therapy

Gene Therapy for Cardiovascular Disease: An Introduction

Gene-Transfer Approaches to Vascular Disease

Gene Transfer Approaches to Myocardial Diseases

Gene Therapy Approaches to Metabolic and Cardiovascular Disorders

Vascular Smooth Muscle Cell Proliferation: Basic Investigations and New Therapeutic Approaches

Editorial Reviews

"
…gets you up to speed on this rapidly expanding area of research.
"-Bulletin of the British Society for Cardiovascular Research

From the Publisher

Reviewer: Elias G. Eleftheriadis, MD (Loyola University Stritch School of Medicine)
Description: This overview of the latest advances in molecular genetics of the cardiovascular diseases is part of the Fundamental and Clinical Cardiology series from Marcel Dekker Inc. There are chapters dedicated to the basic concepts, techniques, and methods currently used to study genetics in humans and in genetically modified animal models. The applications in cardiovascular diseases are also presented.
Purpose: The purpose is to provide the dimensions and highlights of the recent developments in gene mapping and manipulation as they pertain to cardiovascular research and medicine. Genetics in cardiovascular diseases are presented in sufficient detail. The overview in currently used genetically altered animal models to study these disorders makes the book a unique reference book.
Audience: The audience for this book is primarily the basic and clinical scientists interested in the field. The authors are major contributors in their fields and provide a very comprehensive and updated overview.
Features: It is an easy-to-read book with sufficient figures and tables. The references are current, pertinent, and a vital part of the chapters.
Assessment: This is an excellent book. The basics of cardiovascular genetics are explained, the current strategies used to understand the genesis of the cardiovascular diseases are discussed, and the advancements in future treatments, like gene therapy, are presented. Individuals interested in the field as well as academic libraries should have this book.

Doody's Review Service

This overview of the latest advances in molecular genetics of the cardiovascular diseases is part of the Fundamental and Clinical Cardiology series from Marcel Dekker Inc. There are chapters dedicated to the basic concepts, techniques, and methods currently used to study genetics in humans and in genetically modified animal models. The applications in cardiovascular diseases are also presented. The purpose is to provide the dimensions and highlights of the recent developments in gene mapping and manipulation as they pertain to cardiovascular research and medicine. Genetics in cardiovascular diseases are presented in sufficient detail. The overview in currently used genetically altered animal models to study these disorders makes the book a unique reference book. The audience for this book is primarily the basic and clinical scientists interested in the field. The authors are major contributors in their fields and provide a very comprehensive and updated overview. It is an easy-to-read book with sufficient figures and tables. The references are current, pertinent, and a vital part of the chapters. This is an excellent book. The basics of cardiovascular genetics are explained, the current strategies used to understand the genesis of the cardiovascular diseases are discussed, and the advancements in future treatments, like gene therapy, are presented. Individuals interested in the field as well as academic libraries should have this book.

Elias G. Eleftheriadis

...gets you up to speed on this rapidly expanding area of research.

Bulletin of the British Society for Cardiovascular Research

Assembles the recent advances and current trends in the genetic investigation and treatment of cardiovascular diseases. Covers methods of identifying genes in humans, using animals to dissect complex traits, and gene transfer and therapy. Among the specific topics are a non-mathematical overview of modern gene mapping techniques applied to human diseases, genetically altered mouse models of lipoprotein disorders and atherosclerosis, and basic investigations and new therapeutic approaches to vascular smooth- muscle-cell proliferation. Addressed to researchers and specialist clinicians with little or no background in genetics. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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