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Doody's Review ServiceReviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: This textbook teaches upper-level bacterial genetics at the college and graduate level, starting with the basics of molecular structure and building to the mapping of bacterial genomes..
Purpose: The purpose of this sixth edition is to provide an update of the field. In the six years since the previous edition, there has been an extraordinary increase in both the information on bacterial genetics and the techniques used to study them.
Audience: Higher-level students studying bacterial genetics are the intended audience.
Features: The book starts with basic principles of DNA structure, including the various forms DNA takes. It then presents the basic information on hybridization and transcription as well as translation. The explanation of gene organization includes how start and stop codons influence expression and how changes can influence tertiary structure. This is the foundation for the rest of the book, which covers such topics as genetic evolution that relies on variability in the genetic replication, the mechanisms that allow mutations to occur, and how bacterial genes are transferred to other bacterial strains. Later chapters cover new developments and techniques that have contributed to new information such as expression plasmids and specific mutagenesis to examine function. Additional chapters discuss comparative genomics and the analysis of gene expression. The book also demonstrates the relationship of growth in the knowledge of bacterial genomics to other fields such as biotechnology and bioengineering.
Assessment: This update of a popular textbook provides the latest information and techniques used to study bacterial genetics. It provides descriptive information, experimental methods, and clear descriptions of bacterial molecular genetics.