Molecular Genetics of Bacterial Pathogenesis: A Tribute to Stanley Falkow / Edition 1

Molecular Genetics of Bacterial Pathogenesis: A Tribute to Stanley Falkow / Edition 1

by Stanley Falkow
     
 

ISBN-10: 1555810829

ISBN-13: 9781555810825

Pub. Date: 10/28/1994

Publisher: ASM Press

This volume offers a comprehensive overview of the progress in our understanding the microbial pathogenesis of important bacterial pathogens and also offers insights into how these advances have been made via use of recombinant DNA and other molecular techniques. Dr. Stanley Falkow stimulated much of this research through his own work and that of his students. Dr.

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Overview

This volume offers a comprehensive overview of the progress in our understanding the microbial pathogenesis of important bacterial pathogens and also offers insights into how these advances have been made via use of recombinant DNA and other molecular techniques. Dr. Stanley Falkow stimulated much of this research through his own work and that of his students. Dr. Falkow's achievements include seminal discoveries on the nature of plasmids and transposons encoding antibiotic resistance, developing the first DNA probes for the diagnosis of bacterial infections, and being one of the first scientists to study the interactions of a wide variety of bacterial pathogens and host cells.

The introductory chapters and selections in Part 1 depict the state of the art at the time when Dr. Falkow and his staff first began their investigations in the 1960s, describe how key experiments arose, and give a flavor of the laboratory environment at that time. The 29 chapters in Parts 2 through 6 are topical reviews of key areas of molecular pathogenesis currently under investigation by alumni of the Falkow laboratory. All of the scientists contributing to this book worked in Dr. Falkow's laboratory.

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Product Details

ISBN-13:
9781555810825
Publisher:
ASM Press
Publication date:
10/28/1994
Pages:
529
Product dimensions:
6.98(w) x 9.80(h) x 1.36(d)

Table of Contents

Contributors
Foreword
Research and Training Legacy of Stanley Falkow
A Look through the Retrospectoscope
Photographs
1Molecular Nature, Conjugal Transfer, and Replication of Extrachromosomal Elements, 1961 to 19733
2R Plasmids and Antibiotic Resistances17
3Transposon Tn3, 1973 to 198043
4Enterotoxigenic Escherichia coli, 1971 to 197955
5Molecular Epidemiology: Development and Application of Molecular Methods To Solve Infectious Disease Mysteries63
6Adherence Mechanisms in Urinary Tract Infections79
7Escherichia coli Type 1 Pili91
8Mechanisms of Pilus Antigenic Variation in Neisseria gonorrhoeae113
9Type 4 Pili in the Families Moraxellaceae and Neisseriaceae127
10Genes for the Filamentous Hemagglutinin and Fimbriae of Bordetella pertussis: Colocation, Coregulation, and Cooperation?145
11Early Events in the Pathogenesis of Haemophilus influenzae Disease157
12Molecular Pathogenesis of Enteropathogenic Escherichia coli173
13Murine Colonic Hyperplasia197
14Genetic Approaches to Understanding Salmonella Pathogenicity215
15Mechanisms of Yersinia Entry into Mammalian Cells235
16Cell Biology of Salmonella Pathogenesis249
17Intracellular Trafficking of Legionella pneumophila within Phagocytic Cells263
18Cellular Biology of Listeria monocytogenes Infection279
19Determinants of Chlamydial Pathogenesis and Immunity295
20Genetic Analysis of the Escherichia coli K1 Capsule Gene Cluster313
21Type III Capsular Polysaccharide of Group B Streptococci: Role in Virulence and the Molecular Basis of Capsule Expression327
22Unorthodox Secretion by Gram-Negative Bacteria341
23Holistic Perspective on the Escherichia coli Hemolysin351
24Yops of the Pathogenic Yersinia spp365
25Role of Flagella in Campylobacter Pathogenesis383
26Molecular Biology and Role in Disease of the Verotoxins (Shiga-Like Toxins) of Escherichia coli391
27Coordinate Regulation of Virulence in Bordetella pertussis Mediated by the vir (bvg) Locus407
28Methylation-Dependent and Lrp-Dependent Fimbrial Gene Regulation in Escherichia coli423
29The Tao of Urease437
30pJM1 Plasmid-Mediated Iron Transport-Virulence System of Vibrio anguillarum451
31Role of Sucrose Metabolism in the Cariogenicity of the Mutans Streptococci465
32How Many Bacteria Does It Take To Cause Diarrhea and Why?479
33Genetics as a Route toward Mucosal Vaccine Development491
34Phylogenetic Diversity of Microbial Pathogens507
Index519

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