Molecular Genetics of Bacterial Pathogenesis: A Tribute to Stanley Falkow / Edition 1

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Overview

This volume offers a comprehensive overview of the progress in our understanding the microbial pathogenesis of important bacterial pathogens and also offers insights into how these advances have been made via use of recombinant DNA and other molecular techniques. Dr. Stanley Falkow stimulated much of this research through his own work and that of his students. Dr. Falkow's achievements include seminal discoveries on the nature of plasmids and transposons encoding antibiotic resistance, developing the first DNA probes for the diagnosis of bacterial infections, and being one of the first scientists to study the interactions of a wide variety of bacterial pathogens and host cells.

The introductory chapters and selections in Part 1 depict the state of the art at the time when Dr. Falkow and his staff first began their investigations in the 1960s, describe how key experiments arose, and give a flavor of the laboratory environment at that time. The 29 chapters in Parts 2 through 6 are topical reviews of key areas of molecular pathogenesis currently under investigation by alumni of the Falkow laboratory. All of the scientists contributing to this book worked in Dr. Falkow's laboratory.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Mark S. McBride, BS, PhD (University of Wisconsin-Milwaukee)
Description: This book is a tribute to Stanley Falkow, a founder and leader of the field of the molecular genetics of bacterial pathogenesis. It contains a number of chapters written by experts in their respective fields. The first chapters are entertaining historical accounts, although the later chapters survey the recent progress of the Falkow extended family (i.e., his former students and postdocs).
Purpose: The purpose is to survey recent progress in molecular biology of bacterial pathogenesis and present historical accounts of the development of the field. The emphasis is on the impact of Falkow and his students on the field. This is a worthy emphasis considering the staggering impact that the work of this one man has made. The book meets its overall objective well.
Audience: This book is intended for graduate students and other practicing scientists in the field of bacterial pathogenesis. The authors are experts in their fields and have produced a product that should serve this audience well.
Features: The quality of the illustrations, tables, and references varies somewhat between chapters, but is generally quite good. The table of contents and index are also adequate for the book.
Assessment: This is a useful book for students and scientists interested in bacterial pathogenesis. The first five chapters are entertaining for those who are familiar with the individual scientists. They may be less entertaining to the general public but do provide a historical context for the development of this field. Perhaps this section could have been a bit shorter. The remaining chapters are of generally high quality and present up-to-date reviews of the latest advances in this rapidly moving field.
From The Critics
Reviewer: Mark S. McBride, BS, PhD (University of Wisconsin-Milwaukee)
Description: This book is a tribute to Stanley Falkow, a founder and leader of the field of the molecular genetics of bacterial pathogenesis. It contains a number of chapters written by experts in their respective fields. The first chapters are entertaining historical accounts, although the later chapters survey the recent progress of the Falkow extended family (i.e., his former students and postdocs).
Purpose: The purpose is to survey recent progress in molecular biology of bacterial pathogenesis and present historical accounts of the development of the field. The emphasis is on the impact of Falkow and his students on the field. This is a worthy emphasis considering the staggering impact that the work of this one man has made. The book meets its overall objective well.
Audience: This book is intended for graduate students and other practicing scientists in the field of bacterial pathogenesis. The authors are experts in their fields and have produced a product that should serve this audience well.
Features: The quality of the illustrations, tables, and references varies somewhat between chapters, but is generally quite good. The table of contents and index are also adequate for the book.
Assessment: This is a useful book for students and scientists interested in bacterial pathogenesis. The first five chapters are entertaining for those who are familiar with the individual scientists. They may be less entertaining to the general public but do provide a historical context for the development of this field. Perhaps this section could have been a bit shorter. The remaining chapters are of generally high quality and present up-to-date reviews of the latest advances in this rapidly moving field.
Mark S. McBride
This book is a tribute to Stanley Falkow, a founder and leader of the field of the molecular genetics of bacterial pathogenesis. It contains a number of chapters written by experts in their respective fields. The first chapters are entertaining historical accounts, although the later chapters survey the recent progress of the Falkow extended family (i.e., his former students and postdocs). The purpose is to survey recent progress in molecular biology of bacterial pathogenesis and present historical accounts of the development of the field. The emphasis is on the impact of Falkow and his students on the field. This is a worthy emphasis considering the staggering impact that the work of this one man has made. The book meets its overall objective well. This book is intended for graduate students and other practicing scientists in the field of bacterial pathogenesis. The authors are experts in their fields and have produced a product that should serve this audience well. The quality of the illustrations, tables, and references varies somewhat between chapters, but is generally quite good. The table of contents and index are also adequate for the book. This is a useful book for students and scientists interested in bacterial pathogenesis. The first five chapters are entertaining for those who are familiar with the individual scientists. They may be less entertaining to the general public but do provide a historical context for the development of this field. Perhaps this section could have been a bit shorter. The remaining chapters are of generally high quality and present up-to-date reviews of the latest advances in this rapidly moving field.
Booknews
An overview of the progress in understanding microbial pathogenesis of important bacterial pathogens, offering insights into how these advances have been made via use of recombinant DNA and other molecular techniques. The first section of the book describes the experiments of Dr. Stanley Falkow, a pioneer in the field, during the 1960s. Alumni of the Falkow laboratory review key areas of molecular pathogenesis, such as adhesins, extracellular structures and products, and virulence gene regulation. Annotation c. Book News, Inc., Portland, OR booknews.com

3 Stars from Doody
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Product Details

  • ISBN-13: 9781555810825
  • Publisher: ASM Press
  • Publication date: 10/28/1994
  • Edition number: 1
  • Pages: 529
  • Product dimensions: 6.98 (w) x 9.80 (h) x 1.36 (d)

Table of Contents

Contributors
Foreword
Research and Training Legacy of Stanley Falkow
A Look through the Retrospectoscope
Photographs
1 Molecular Nature, Conjugal Transfer, and Replication of Extrachromosomal Elements, 1961 to 1973 3
2 R Plasmids and Antibiotic Resistances 17
3 Transposon Tn3, 1973 to 1980 43
4 Enterotoxigenic Escherichia coli, 1971 to 1979 55
5 Molecular Epidemiology: Development and Application of Molecular Methods To Solve Infectious Disease Mysteries 63
6 Adherence Mechanisms in Urinary Tract Infections 79
7 Escherichia coli Type 1 Pili 91
8 Mechanisms of Pilus Antigenic Variation in Neisseria gonorrhoeae 113
9 Type 4 Pili in the Families Moraxellaceae and Neisseriaceae 127
10 Genes for the Filamentous Hemagglutinin and Fimbriae of Bordetella pertussis: Colocation, Coregulation, and Cooperation? 145
11 Early Events in the Pathogenesis of Haemophilus influenzae Disease 157
12 Molecular Pathogenesis of Enteropathogenic Escherichia coli 173
13 Murine Colonic Hyperplasia 197
14 Genetic Approaches to Understanding Salmonella Pathogenicity 215
15 Mechanisms of Yersinia Entry into Mammalian Cells 235
16 Cell Biology of Salmonella Pathogenesis 249
17 Intracellular Trafficking of Legionella pneumophila within Phagocytic Cells 263
18 Cellular Biology of Listeria monocytogenes Infection 279
19 Determinants of Chlamydial Pathogenesis and Immunity 295
20 Genetic Analysis of the Escherichia coli K1 Capsule Gene Cluster 313
21 Type III Capsular Polysaccharide of Group B Streptococci: Role in Virulence and the Molecular Basis of Capsule Expression 327
22 Unorthodox Secretion by Gram-Negative Bacteria 341
23 Holistic Perspective on the Escherichia coli Hemolysin 351
24 Yops of the Pathogenic Yersinia spp 365
25 Role of Flagella in Campylobacter Pathogenesis 383
26 Molecular Biology and Role in Disease of the Verotoxins (Shiga-Like Toxins) of Escherichia coli 391
27 Coordinate Regulation of Virulence in Bordetella pertussis Mediated by the vir (bvg) Locus 407
28 Methylation-Dependent and Lrp-Dependent Fimbrial Gene Regulation in Escherichia coli 423
29 The Tao of Urease 437
30 pJM1 Plasmid-Mediated Iron Transport-Virulence System of Vibrio anguillarum 451
31 Role of Sucrose Metabolism in the Cariogenicity of the Mutans Streptococci 465
32 How Many Bacteria Does It Take To Cause Diarrhea and Why? 479
33 Genetics as a Route toward Mucosal Vaccine Development 491
34 Phylogenetic Diversity of Microbial Pathogens 507
Index 519
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