Molecular Genetics of Cancer / Edition 2

Molecular Genetics of Cancer / Edition 2

by John Cowell
     
 

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ISBN-10: 185996169X

ISBN-13: 9781859961698

Pub. Date: 04/01/2001

Publisher: Taylor & Francis

Molecular Genetics of Cancer, Second Edition, provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to

Overview

Molecular Genetics of Cancer, Second Edition, provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.

Product Details

ISBN-13:
9781859961698
Publisher:
Taylor & Francis
Publication date:
04/01/2001
Pages:
536
Product dimensions:
6.14(w) x 9.21(h) x 1.19(d)

Table of Contents

THE GENETICS OF BREAST AND OVARIAN CANCER
Introduction.
Hereditary breast and ovarian cancer syndromes.
Non-hereditary breast and ovarian cancer.
Conclusions.
GENETICS OF VON HIPPEL-LINDAU DISEASE
Introduction.
Clinical aspects.
VHL disease and isolated features of VHL disease.
Molecular genetics of VHL disease.
Genotype/phenotype.
VHL and sporadic tumorigenesis.
VHL and development.
VHL gene function.
Conclusion.
GENETICS OF NF1 AND NF2
History and nomenclature of NF1 and NF2.
Clinical features of NF1.
Genetics of NF1.
Tumor genetics.
NF2 clinical and genetic information.
The NF2 gene and protein.
Germline NF2 mutations.
The NF2 gene is a tumor suppressor.
Conclusions and future directions.
GENETICS OF GASTRIC CANCER
Epidemiology.
Pathology.
Genetic alterations and gastric carcinogenesis.
Genomic instability and gastric cancer.
Conclusions.
MULTIPLE ENDOCRINE NEOPLASIA TYPE 1
Introduction.
Clinical manifestations.
Positional cloning of the MEN1 gene.
The MEN1 gene.
The functions of the MEN1 gene.
Homologous genes.
MEN1 mutations.
Genotype-phenotype correlation.
Mitogenic factors and chromosome instability.
Conclusions.
MULTIPLE ENDOCRINE NEOPLASIA TYPE 2
Introduction.
Clinical features of MEN2.
Genetics of MEN2.
Germline RET mutations in Hirschsprung disease.
Clinical management of individuals-at-risk.
The RET proto-oncogene.
Animal models.
The triumph of molecular oncology and the dilemma of penetrance and expressional modification.
TP53 IN CANCER ORIGIN AND TREATMENT
Introduction.
TP53 gene structure and regulation.
Cell growth control by TP53.
Mechanisms of TP53 regulation.
TP53 in the organism.
TP53 in the tumor.
TP53 and cancer treatment.
CORORECTAL CANCER
Introduction.
Family history and CRC risk.
Genetic factors predisposing to CRC.
Inherited CRC predisposition.
Modifiers and genes of minor effect: allelic variants.
Personal history and risk.
Prevention.
Social considerations.
Conclusions.
GENETICS OF PROSTATE CANCER
Introduction.
Somatic genetic changes in prostate cancer development.
Inherited susceptibility to prostate cancer - overview.
Epidemiological evidence for the presence of prostate cancer susceptibility genes.
Segregation analyses.
Linkage studies.
Association analyses.
Possible correlations of phenotype and genotype.
TUBEROUS SCLEROSIS COMPLEX
Clinical aspects of tuberous sclerosis complex.
Genes involved in the tuberous sclerosis complex.
Functional characterisation of the TEC1 and TSC2 gene products.
Genetic counselling for TSC.
RETINOBLASTOMA: PATIENTS, TUMORS, GENE AND PROTEIN CONTRIBUTE TO THE UNDERSTANDING OF CANCER
Introduction.
Retinoblastoma tumors and the RB1 gene.
Therapy of retinoplastoma.
Disruption of the RB pathway in neoplasia.
Cellular function of pRB.
Summary.
GENETICS OF WILMS TUMOR
Introduction.
The 11p13 locus and the wilms tumor suppressor gene.
The 11p15 locus and loss imprinting in wilms tumor.
Other genetic loci associated with wilms tumor.
Conclusions.
GENETICS OF NEUROBLASTOMA
Introduction.
Neuroblastoma predisposition.
Loss of genetic material and inactivation of tumor suppressor genes.
Gain of genetic material and oncogene activation.
Alterations in gene expression.
Genetic model of neuroblastoma development.
GENETICS OF BRAIN TUMORS
Introduction.
Astrocytomas.
Oligodendrogliomas.
Ependymonas.
Medulloblastomas.
Meningioma and schwannoma.
atypical teratoid/rhabdoid tumors.
Summary.
MOLECULAR GENETICS OF LUNG CANCER
Introduction.
Histologic types of lung cancer.
Cytogenetics of lung cancer.
Recessive genes frequently targeted in lung cancer.
Dominant oncogenes in lung cancer.
Therapeutic considerations.
Conclusions.
GENETICS OF LIVER CANCER
Introduction.
Pathogenesis.
Tumor suppressors and cyclin-dependant kinase inhibitors.
Oncogenes.
Allelotype.
DNA methylation.
Tumors of multifocal origin and intrahepatic metastases.
A molecular model of human hepatocarcinogenesis.
THE GENETICS OF BLADDER CENTRE
Aetiology and epidemiology.
Chromosomal alterations in TCC.
Oncogenes involved in TCC development.
A model for TCC progression.
Genetics of schistomomiasis- associated bladder cancer.
Conclusion.
GENETICS OF RHABDOMYOSARCOMA
Introduction.
Chromosomal translocations in ARMS.
11p15 allelic loss in ERMS.
Other genetic changes in RMS.
Altered pathways in sporadic RMS and inherited cancer predisposition syndromes.
RMS mouse models.
Conclusions.
ROLE OF TELOMERES AND TELOMERASE IN AGING AND CANCER
Introduction.
Dyskeratosis congenita.
Ataxia telangiectasia.
Nijmegan breakage syndrome.
Werner syndrome.
Progeria.
Fanconi anemia.
Li fraumeni syndrome.
Additional disorders associated with chromosome instability.
Conclusions.
INDEX.

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