Molecular Genetics of Liver Neoplasia / Edition 1

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More About This Textbook


An exciting overview of the advances in the genetics and biology of liver cancer, diagnosis, treatment and prevention Chapters range from genetics and environmental risk factors, genetics of liver development and pathogenesis, epigenetic changes associated with liver cancer, the utilities of genetic animal models, cancer stem cells, applying gene expression profiling by microarrays to liver cancer, to liver cancer genetics in the clinic Cancer is a genetic disease and cancer research is a broad discipline embracing investigators and clinicians with diverse backgrounds. This new edition of Molecular Genetics of Liver Neoplasia intends to provide a comprehensive view on genetics and mechanistic understanding of liver cancer. The book covers from molecular pathogenesis, cellular origin to translational genomics of liver cancer. The leading experts in the field of liver cancer have thoroughly summarized the latest developments and have provided current viewpoints and novel concepts. This cutting-edge monograph is a vital resource for today's basic cancer researchers, graduate students, medical students and clinicians who are interested in hepatocarcinogenesis.

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Product Details

  • ISBN-13: 9781441960818
  • Publisher: Springer New York
  • Publication date: 11/1/2010
  • Series: Cancer Genetics Series
  • Edition description: 2011
  • Edition number: 1
  • Pages: 399
  • Product dimensions: 6.30 (w) x 9.20 (h) x 1.10 (d)

Table of Contents

Part I Introduction

1 Biology of Hepatocellular Carcinoma: Past, Present and Beyond Xin Wei Wang Joe W. Grisham Snorri S. Thorgeirsson 3

2 Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum Joe W. Grisham Xin Wei Wang Snorri S. Thorgeirsson 19

Part II Liver Cancer Development and Pathogenesis

3 Pathology of Hepatocellular Carcinoma Masamichi Kojiro 37

Part III Genetics and Epidemiology of Liver Cancer

4 Epidemiology of Hepatocellular Carcinoma Donna L. White Hashem B. El-Serag 51

5 Genetics and Epidemiology of Cholangiocarcinoma Boris R.A. Blechacz Gregory J. Gores 75

Part IV Molecular Basis of Cancer Susceptibility

6 Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinoma Jack R. Wands Miran Kim 103

7 Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma David R. McGivern Stanley M. Lemon 129

8 DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinoma Yae Kanai Eri Arai 147

Part V Animal Models

9 Transgenic and Knockout Mouse Models of Liver Cancer Diego F. Calvisi Valentina M. Factor Snorri S. Thorgeirsson 163

10 Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinoma Lars Zender Scott W. Lowe 189

11 The Zebrafish Model for Liver Carcinogenesis Zhiyuan Gong Chor Hui Vivien Koh Anh Tuan Nguyen Huiqing Zhan Zhen Li Siew Hong Lam Jan M. Spitsbergen Alexander Emelyanov Serguei Parinov 197

Part VI Global Gene Expression Profiling of Human Liver Cancer

12 Integrative and Functional Genomics of HCC C├ędric Coulouarn Snorri S. Thorgeirsson 221

13 Molecular Signatures of Hepatocellular Carcinoma Metastasis Anuradha Budhu Xin Wei Wang 241

14 Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors Jessica Zucman-Rossi 259

Part VII Cancer Stem Cells

15 Cancer Stem Cells and Liver Cancer Jens U. Marquardt Snorri S. Thorgeirsson 279

16 Heterogeneity of Liver Cancer Stem Cells Taro Yamashita Masao Honda Shuichi Kaneko 301

17 Cancer Stem Cells in Liver Carcinoma Tania Roskams 319

Part VIII Liver Cancer Genetics in the Clinic

18 Molecular Signaling in Hepatocellular Carcinoma Hong Yang Wang Jin Ding 337

19 Molecular Events on Metastasis of Hepatocellular Carcinoma Zhao-You Tang Lun-Xiu Qin Hui-Chuan Sun Qing-Hai Ye 349

20 Molecular Pathogenesis of Hepatocellular Carcinoma Chun Ming Wong Judy Wai Ping Yam Irene O.L. Ng 373

Subject Index 397

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