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Molecular Hematology / Edition 3

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Overview

Now in its third edition, Molecular Hematology has been thoroughly updated to incorporate recent advances in molecular research. The aim of the book remains the same – to provide a core knowledge base for those with little exposure to molecular biological techniques.

Molecular biology has had a significant impact on the understanding of blood diseases and this book shows how molecular techniques can be used in diagnosis and treatment. In each chapter the authors summarize the impact made by molecular research on the understanding of the pathogenesis of the disorder featured, and highlight the molecular strategies that exist, or are being currently investigated, for therapeutic purposes. There are six brand new chapters in this edition:

  • History and development of molecular biology
  • Pharmacogenomics
  • Anemia of chronic disease
  • Molecular pathogenesis of malaria
  • Molecular basis of transplantation
  • Cancer stem cells

Presented in an extremely readable style with clear two-color line diagrams, this book is designed for the non-specialist and will be an invaluable resource for all trainee hematologists.

The book contains both black-and-white and color illustrations.

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Editorial Reviews

From the Publisher
"This is a well-written book in which there seems to be a genuine desire to communicate the practical value as well as the insights into aetiology provided by successive developments in the field of molecular haematology." (The Bulletin, 1 October 2011)
Booknews
Written with the non-specialist in mind, this book demonstrates the relevance of advances in molecular biology to hematologists' day-to- day practice<-->highlighting the impact molecular biology has had on the diagnostic aspects of disease management as well as therapeutic strategies that have been developed as a result of basic molecular biological investigation. Provan (Southampton General Hospital, UK) and Gribben (Harvard Medical School) have assembled 16 chapters covering topics such as molecular cytogenetics; detection of minimal residual disease in hematological malignancies; hemoglobinopathies due to structural mutations; hematopoietic growth factors; and molecular therapeutics in hematology. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781405182317
  • Publisher: Wiley
  • Publication date: 5/17/2010
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 428
  • Product dimensions: 8.60 (w) x 10.90 (h) x 1.10 (d)

Meet the Author

Drew Provan MD FRCP FRCPath

Senior Lecturer, Centre for Haematology, Institute of Cell and Molecular Science, Barts and The London School of Medicine & Dentistry, The Royal London Hospital, London, UK

John G. Gribben MD DSc FMedSci

Professor, Centre for Experimental Cancer Medicine, Institute of Cancer, Barts and The London School of Medicine & Dentistry, London, UK

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Table of Contents

List of Contributors.

Foreword.

Preface.

Abbreviations.

1 Beginnings: The Molecular Pathology of Hemoglobin (David Weatherall).

2 Molecular cytogenetics and array based genomic analysis (Debra M. Lillington, Silvana Debernardi & Bryan D. Young).

3 Stem Cells (Eyal C. Attar & David T. Scadden).

4 The Genetics of Acute Myeloid Leukemias (Carolyn J. Owen & Jude Fitzgibbon).

5 Secondary myelodysplasia/acute myelogenous leukemia – assessment of risk (John G. Gribben).

6 Detection of Minimal Residual Disease in Hematologic Malignancies (Drew Provan).

7 Chronic Myelogenous Leukemia (Alfonso Quintás-Cardama, Jorge Cortes, Hagop Kantarjian, Susan O’Brien).

8 Myelodysplastic Syndromes (M. Mansour Ceesay, Wendy Ingram, Ghulam J Mufti).

9 Myeloproliferative Disorders (Anthony J. Bench, George S. Vassiliou & Anthony R. Green).

10 Lymphoma Genetics (Anthony G. Letai & John G. Gribben).

11 The Molecular Biology of Multiple Myeloma (Wee Joo Chng and P. Leif Bergsagel).

12 The Molecular Basis of Anemia (Lucio Luzzatto & Anastasios Karadimitris).

13 Anemia of chronic disease (Tomas Ganz).

14 Molecular Basis of Iron Metabolism (Nancy C. Andrews and Tomas Ganz).

15 Hemoglobinopathies due to Structural Mutations (D. Mark Layton and Ronald L. Nagel).

16 Molecular Pathogenesis of Malaria (David Roberts).

17 Molecular Coagulation and Thrombophilia (Björn Dahlbäck & Andreas Hillarp).

18 The Molecular Basis of Hemophilia (Paul L. F. Giangrande).

19 The Molecular basis of von Willebrand Disease (Luciano Baronciani and Pier Mannuccio Mannucci).

20 Platelet Disorders (Kenneth J. Clemetson).

21 The Molecular Basis of Blood Cell Alloantigens (Willem H. Ouwehand & Cristina Navarrete).

22 Functions of Blood Group Antigens (Marilyn J. Telen).

23 Autoimmune hematologic disorders (Drew Provan, John W. Semple & Adrian C. Newland).

24 Hematopoietic Growth Factors: A 40 Year Journey from Crude “Activities” to Therapeutic Proteins (Graham Molineux and Stephen J. Szilvassy).

25 Molecular Therapeutics in Hematology: Gene Therapy (Jeffrey A. Medin).

26 Pharmacogenomics (Leo Kager and William E. Evans).

27 Gene expression profiling in the study of lymphoid malignancies (Ulf Klein & Riccardo Dalla-Favera).

28 An Introduction to Molecular Biology (Paul Moss).

29 Cancer stem cells (David C. Taussig and Dominique Bonnet).

30 Molecular basis of transplant (Francesco Dazzi).

Index.

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