Molecular Hematology / Edition 2

Molecular Hematology / Edition 2

by Drew Provan
     
 

The treatment of blood disease has been revolutionised in recent years by the use of therapies borne out of the fruits of the application of molecular biology. Haematology, more than any other discipline, relies on molecular biology for the diagnosis and management of patients. Haematologists need to understand the molecular biology that underpins many of the

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Overview

The treatment of blood disease has been revolutionised in recent years by the use of therapies borne out of the fruits of the application of molecular biology. Haematology, more than any other discipline, relies on molecular biology for the diagnosis and management of patients. Haematologists need to understand the molecular biology that underpins many of the treatments that are now used in day to day practice. However, there are few books available devoted specifically to molecular haematology, and those that are available are highly detailed reference texts of value only to those familiar with the subject. Molecular Haematology is a unique text which bridges this gap and provides a core knowledge base for those with little exposure to molecular biological methods. The text comprises 16 chapters, each of which is devoted to a specific area of haematology. There is coverage of malignant and non-malignant disease, anaemias, blood transfusion, and molecular therapeutics. Each article summarises the impact made by molecular research on our understanding of the pathogenesis of the disorder, and highlights the molecular strategies that exist, or are being currently investigated, both therapeutically and for investigative purposes. Presented in an extremely readable style with clear two-colour line diagrams, this text summarises the enormous impact that molecular biology has already had on the clinical practice of haematology, and identifies opportunities in clinical care in the future. Molecular Haematology provides essential reading for those with minimal exposure to, or understanding of, molecular biological techniques. There is an extensive glossary and each chapter is written with the non-specialist in mind.

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Product Details

ISBN-13:
9781405112550
Publisher:
Wiley
Publication date:
02/28/2005
Edition description:
REV
Pages:
344
Product dimensions:
8.40(w) x 10.90(h) x 1.00(d)

Meet the Author

Drew Provan MD FRCP FRCPath

Senior Lecturer, Centre for Haematology, Institute of Cell and Molecular Science, Barts and The London School of Medicine & Dentistry, The Royal London Hospital, London, UK

John G. Gribben MD DSc FMedSci

Professor, Centre for Experimental Cancer Medicine, Institute of Cancer, Barts and The London School of Medicine & Dentistry, London, UK

Table of Contents

1Beginnings : the molecular pathology of hemoglobin1
2Molecular cytogenetics18
3Stem cells25
4The genetics of acute myeloid leukemias41
5Secondary myelodysplasia/acute myelogenous leukemia - assessment of risk47
6Detection of minimal residual disease in hematological malignancies53
7Chronic myeloid leukemia72
8Myelodysplastic syndromes82
9Myeloproliferative disorders90
10Lymphoid neoplasms105
11The molecular biology of multiple myeloma115
12The molecular basis of anemia125
13The molecular basis of iron metabolism150
14Hemoglobinopathies due to structural mutations159
15Molecular coagulation and thrombophilia173
16The molecular basis of hemophilia184
17The molecular basis of von Willebrand disease199
18Platelet disorders210
19The molecular basis of blood cell alloantigens225
20Functions of blood group antigens241
21Autoimmune hematological disorders251
22Hematopoietic growth factors267
23Molecular therapeutics in hematology280
24Gene expression profiling in the study of lymphoid malignancies298

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