Molecular Hematology / Edition 2by Drew Provan
Pub. Date: 02/28/2005
The treatment of blood disease has been revolutionised in recent years by the use of therapies borne out of the fruits of the application of molecular biology. Haematology, more than any other discipline, relies on molecular biology for the diagnosis and management of patients. Haematologists need to understand the molecular biology that underpins many of the… See more details below
The treatment of blood disease has been revolutionised in recent years by the use of therapies borne out of the fruits of the application of molecular biology. Haematology, more than any other discipline, relies on molecular biology for the diagnosis and management of patients. Haematologists need to understand the molecular biology that underpins many of the treatments that are now used in day to day practice. However, there are few books available devoted specifically to molecular haematology, and those that are available are highly detailed reference texts of value only to those familiar with the subject. Molecular Haematology is a unique text which bridges this gap and provides a core knowledge base for those with little exposure to molecular biological methods. The text comprises 16 chapters, each of which is devoted to a specific area of haematology. There is coverage of malignant and non-malignant disease, anaemias, blood transfusion, and molecular therapeutics. Each article summarises the impact made by molecular research on our understanding of the pathogenesis of the disorder, and highlights the molecular strategies that exist, or are being currently investigated, both therapeutically and for investigative purposes. Presented in an extremely readable style with clear two-colour line diagrams, this text summarises the enormous impact that molecular biology has already had on the clinical practice of haematology, and identifies opportunities in clinical care in the future. Molecular Haematology provides essential reading for those with minimal exposure to, or understanding of, molecular biological techniques. There is an extensive glossary and each chapter is written with the non-specialist in mind.
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Table of Contents
List of Contributors.
1 Beginnings: The Molecular Pathology of Hemoglobin.
2 Molecular Cytogenetics.
3 Stem Cells.
4 The Genetics of Aacute Myeloid Leukemias.
5 Secondary Myelodysplasia/acute Myelogenous Leukemia—assessment of Risk.
6 Detection of Minimal Residual Disease in Hematological Malignancies.
7 Chronic Myeloid Leukaemia.
8 Myelodysplastic Syndromes.
9 Myeloproliferative Disorders.
10 Lymphoid Neoplasms.
11 The Molecular Biology of Multiple Myeloma.
12 The Molecular Basis of Anaemia.
13 The Moloecular Basis of Iron Metabolism.
14 Hemoglobinopathies Due to Structural Mutations.
15 Molecular Coagulation and Thrombophilia.
16 The Molecular Basis of Haemophilia.
17 The Moloecular Basis of Von Willebrands Disease.
18 Platelet Disorders.
19 The Molecular Basis of Blood Cell Alloantigens.
20 Functions of Blood Group Antigens.
21 Autoimmune Hematological Disorders.
22 Hemotopoietic Growth Factors.
23 Molecular Therapeutics in Hematology.
24 Gene Expression Profiling in the Study of Lymphoid Malignancies.
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