Molecular Hematology / Edition 2

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The treatment of blood disease has been revolutionised in recent years by the use of therapies borne out of the fruits of the application of molecular biology. Haematology, more than any other discipline, relies on molecular biology for the diagnosis and management of patients. Haematologists need to understand the molecular biology that underpins many of the treatments that are now used in day to day practice. However, there are few books available devoted specifically to molecular haematology, and those that are available are highly detailed reference texts of value only to those familiar with the subject. Molecular Haematology is a unique text which bridges this gap and provides a core knowledge base for those with little exposure to molecular biological methods. The text comprises 16 chapters, each of which is devoted to a specific area of haematology. There is coverage of malignant and non-malignant disease, anaemias, blood transfusion, and molecular therapeutics. Each article summarises the impact made by molecular research on our understanding of the pathogenesis of the disorder, and highlights the molecular strategies that exist, or are being currently investigated, both therapeutically and for investigative purposes. Presented in an extremely readable style with clear two-colour line diagrams, this text summarises the enormous impact that molecular biology has already had on the clinical practice of haematology, and identifies opportunities in clinical care in the future. Molecular Haematology provides essential reading for those with minimal exposure to, or understanding of, molecular biological techniques. There is an extensive glossary and each chapter is written with the non-specialist in mind.

The book contains both black-and-white and color illustrations.

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Editorial Reviews

Written with the non-specialist in mind, this book demonstrates the relevance of advances in molecular biology to hematologists' day-to- day practice<-->highlighting the impact molecular biology has had on the diagnostic aspects of disease management as well as therapeutic strategies that have been developed as a result of basic molecular biological investigation. Provan (Southampton General Hospital, UK) and Gribben (Harvard Medical School) have assembled 16 chapters covering topics such as molecular cytogenetics; detection of minimal residual disease in hematological malignancies; hemoglobinopathies due to structural mutations; hematopoietic growth factors; and molecular therapeutics in hematology. Annotation c. Book News, Inc., Portland, OR (
From the Publisher
"This is a well-written book in which there seems to be a genuine desire to communicate the practical value as well as the insights into aetiology provided by successive developments in the field of molecular haematology." (The Bulletin, 1 October 2011)
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Product Details

  • ISBN-13: 9781405112550
  • Publisher: Wiley
  • Publication date: 2/28/2005
  • Edition description: REV
  • Edition number: 2
  • Pages: 344
  • Product dimensions: 8.40 (w) x 10.90 (h) x 1.00 (d)

Meet the Author

Drew Provan MD FRCP FRCPath

Senior Lecturer, Centre for Haematology, Institute of Cell and Molecular Science, Barts and The London School of Medicine & Dentistry, The Royal London Hospital, London, UK

John G. Gribben MD DSc FMedSci

Professor, Centre for Experimental Cancer Medicine, Institute of Cancer, Barts and The London School of Medicine & Dentistry, London, UK

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Table of Contents

1 Beginnings : the molecular pathology of hemoglobin 1
2 Molecular cytogenetics 18
3 Stem cells 25
4 The genetics of acute myeloid leukemias 41
5 Secondary myelodysplasia/acute myelogenous leukemia - assessment of risk 47
6 Detection of minimal residual disease in hematological malignancies 53
7 Chronic myeloid leukemia 72
8 Myelodysplastic syndromes 82
9 Myeloproliferative disorders 90
10 Lymphoid neoplasms 105
11 The molecular biology of multiple myeloma 115
12 The molecular basis of anemia 125
13 The molecular basis of iron metabolism 150
14 Hemoglobinopathies due to structural mutations 159
15 Molecular coagulation and thrombophilia 173
16 The molecular basis of hemophilia 184
17 The molecular basis of von Willebrand disease 199
18 Platelet disorders 210
19 The molecular basis of blood cell alloantigens 225
20 Functions of blood group antigens 241
21 Autoimmune hematological disorders 251
22 Hematopoietic growth factors 267
23 Molecular therapeutics in hematology 280
24 Gene expression profiling in the study of lymphoid malignancies 298
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