Preface: E.S. Gonos, I.P. Trougakos, and N. Chondrogianni.
Part I: Overview of Mammalian Aging and Senescence:.
1. Clonal attenuation of somatic cells in aging mammals: a review of supportive evidence and its biomedical significance: G. Martin.
Part II: Cell Signaling and Replicative Senescence:.
2. Exposure of human diploid fibroblasts to hypoxia extends proliferative lifespan: E. Poulios, I.P. Trougakos, N. Chondrogianni, E.S. Gonos.
3. Cyclin D1 over-expression permits the reproducible detection of senescent human vascular smooth muscle cells: D.G.A. Burton, A.N. Sheerin, E.L. Ostler, K. Smith, P.J. Giles, J. Lowe, W. Rhys-Williams, D.G. Kipling, R.G.A. Faragher.
Part III: Biomarkers of Aging:.
4. Morphological changes associated with aging: age spots and the micro-inflammatory model of skin aging: E. Goyarts, N. Muizzuddin, D. Maes, P.U. Giacomoni.
5. Molecular mechanisms of skin aging: State of the art: E. Makrantonaki, C.C. Zouboulis.
Part IV: DNA Repair and Aging:.
6. Acquisition of oxidative DNA damage during senescence: the first step towards carcinogenesis?: S. Martien, C. Abbadie.
7. The effect of the histone deacetylase inhibitor, trichostatin A, in human peripheral blood lymphocytes as a function of donor age: T.G. Sourlingas, Y. Ninios, K.P. Kypreou, G.N. Topakas, I.N. Karchilaki, C. Stavropoulos-Giokas, K.E. Sekeri-Pataryas.
Part V: Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance:.
8. Transient increased extracellular release of H2O2 during establishment of UVB induced premature senescence: C. Borlon, A. Chretien, F. Debacq-Chainiaux, O. Toussaint.
9. Importance of the Lon Protease in Mitochondrial Maintenance and the Significance of Declining Lon in Aging: J. K. Ngo, K. J. A. Davies.
10. Protein oxidative modifications and replicative senescence of WI-38 human embryonic fibroblasts: T. Jung, N. Bader, T. Grune.
11. Lipofuscin: formation, distribution and metabolic consequences: T. Jung, N. Bader, T. Grune.
Part VI: Intervention:.
12. Stress-Mediated Hormetic Modulation of Aging, Wound Healing and Angiogenesis in Human Cells: S.I.S. Rattan, H. Sejersen, R.A. Fernandes, W. Luo.
13. Retarding aging in humans in reality by diminishing risks to health: Ü. Kristjuhan.
14. Zinc, metallothioneins and longevity. Effect of zinc supplementation: Zincage study: E. Mocchegiani, R. Giacconi, C. Cipriano, L. Costarelli, E. Muti, S. Tesei, C. Giuli, R. Papa, F. Marcellini, E. Mariani, L. Rink, G. Herbein, A. Varin, T. Fulop, D. Monti, J. Jajte, G. Dedoussis, E.S. Gonos, I.P. Trougakos, M. Malavolta.
15. Ghrelin receptor (GHS-R1a) agonists show potential as interventive agents during aging: R.G. Smith, Y. Sun, H. Jiang, R. Albarran-Zeckler, N. Timchenko.
Part VII: Molecular Links between Aging and Cancer:.
16. Functional significance of minor structural and expression changes of stress chaperone mortalin: C.C. Deocaris, N. Widodo, T. Ishii, S.C. Kaul, R. Wadhwa.
17. GRO-alpha: A Potential Marker for Cancer and Aging Silenced by RNA Interference: S. Fimmel, L. Devermann, A. Hermann, C.C. Zouboulis.
18. Caspase-3 and Bcl-2 expression along ageing in adrenal zona reticularis after dexamethasone administration: H. Almeida, L. Matos, D. Neves.
Part VIII: Age-Related Diseases:.
19. Nutraceutical strategy in ageing: Targeting heat shock protein and inflammatory profile via IL-6 polymorphism understanding: F. Marotta, K. Koike, A. Lorenzetti, Y. Naito, F. Fayet, Y. Shimizu, P. Marandola.
20. Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful ageing: C.R. Balistreri, G. Candore, F. Listi, T. Fazio, S. Ganci, E. Incalcatera, M. Caruso, M. Li Vecchi, D. Lio, C. Caruso.
21. Pro-NGF, sortilin and age-related neurodegeneration: R. Al-Shawi, A. Hafner, S. Chun, S. Raza, K. Crutcher, C. Thrasivoulou, P. Simons, T. Cowen.
22. Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection: T. Chiba, S. Fujita, H. Kubota, D. Inoue, A. Mizuno, T. Komatsu, H. Yamaza, Y. Higami, I. Shimokawa.
23. Acute myocardial infarction and pro-inflammatory gene variants: F. Licastro, M. Chiapelli, C.M. Caldarera, C. Caruso, D. Lio, E.H. Corder.
24. Bone mineral density in Ukrainan women of different age: V.V. Povoroznyuk, N. Dzerovich, T.A. Karasevskaya.
Part IX: Model Organisms:.
25. Sex-specific effects of the DAF-12 steroid receptor on ageing in Caenorhabditis elegans: D. McCulloch, D. Gems.
26. Modulating longevity in Drosophila by over- and under-expression of glutamate-cysteine ligase: J. Luchak, I. Prabhudesai, R. Sohal, S. Radyuk, W.C. Orr.
27. Modelling Werner’s syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease: L. Cox, D.J. Clancy, I. Boubriak, R.D.C. Saunders.
28. Protein synthesis is a novel determinant of ageing in C. Elegans: P. Syntichaki, K. Troulinaki, N. Tavernarakis.
Part X: Evolutionary and Epidemiological Aspects of Aging:.
29. Calorie restriction, post-reproductive life span and programmed aging: a plea for rigour: A.D.N.J. de Grey.
30. Non-pathological senescence arises from unsuitable external influences: A. Khalyavkin, A. Yashin