Molecular Mechanisms of Desensitization to Signal Molecules

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Product Details

  • ISBN-13: 9783642717840
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 7/31/2012
  • Series: Nato ASI Subseries H: (closed) , #6
  • Edition description: Softcover reprint of the original 1st ed. 1987
  • Edition number: 1
  • Pages: 356
  • Product dimensions: 6.69 (w) x 9.61 (h) x 0.74 (d)

Table of Contents

Chemotaxis and Chemosensing.- Behavioral adaptation in prokaryotes.- Discussion.- Surface receptor mediated activation and adaptation of adenylate cyclase in Dictyostelium discoideum.- Discussion.- Adaptation of Dictyostelium discoideum cells to chemotactic signals.- Discussion.- Adaptation, periodic signalling, and receptor modification.- Discussion.- Adenylate Cyclase-Coupled Systems.- Glucagon desensitization of adenylate cyclase in hepaytes: an action mediated by a distinct population of glucagon receptors coupled to stimulate inositol phospholipid metabolism.- Discussion.- Cellular adaptation to signal molecules: activation and interaction of different signal transduction systems.- Discussion.- Desensitization of the—-adrenergic coupled adenylate cyclase. The—-adrenergic receptor kinase phosphorylates agonist-occupied cyclase-coupled receptors.- Discussion.- Structural microheterogeneity of ß1-adrenoceptors in turkey erythrocytes and their functional consequences.- Discussion.- Adaptive response of beta-adrenergic sensitive adenylate cyclase system.- Discussion.- Hormone specific desensitization of Sertoli cell adenylate cyclase in a cell-free system.- Discussion.- Inositol Phospholipid-Coupled Systems.- Adaptations of receptor-dependent phosphatidylinositol 4,5-bisphosphate breakdown.- Discussion.- Cell responses to phosphoinositide-hydrolysing receptors: some potential sites of modulation.- Discussion.- The kinase C substrate protein B-50 and feedback control of synaptic signal transduction.- Discussion.- Retroinhibition of the calcium-phosphatidylinositol cascade by diacylglycerol in thyroid.- Discussion.- Visual Transduction.- Fast termination and adaptation processes in the cGMP cascade of visual transduction.- Discussion.- Phosphorylation of rhodopsin involved in terminating the visual response.- Discussion.- Ion Conductance.- Permeability control and desensitization by nicotinic acetylcholine receptors.- Discussion.- Cellular Systems.- Regulation of leukocyte responses to chemoattractants: role of receptors, guanine nucleotide regulatory (N) proteins and phospholipase C.- Modulation of macrophage oxygen metabolism. Evidence for desensitization and activation of the cell response to environmental stimuli.- Discussion.- Antibody induced down regulation of membrane receptors in human diseases.- Discussion.- Concluding Remarks.
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