Molecular Neuropathology

Overview

This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using ...

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Overview

This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: This book describes some basic methods of molecular studies in pathology of CNS disorders and gives selected examples of their application. All 11 chapters are written by different authors.
Purpose: The book is divided into two parts, the first on techniques and the second on their applications. All chapters are presented in different format with no apparent involvement of the editors. Part 1 contains a chapter on brain banks compiled in very general terms with no specific recommendations; a chapter on PCR with no specific reference to CNS, a chapter on RNA isolation with some useful notes; and chapters on in situ hybridization, immunocytochemistry, and autoradiography. Only one chapter contains an experimental protocol (immunostaining procedure). The second part of the book was intended to illustrate the application of the methods described in the first. Indeed, chapters on prion diseases and amyloidoses are fully relevant. The chapter on intracerebral transplantations, though quite informative, lies more on the physiological side. The chapter on transgenic animals belongs rather to the first part because of the complexity of the described methods and limited number of examples. The last chapter on quantitative imaging presents concise discussion of the potential advantages and pitfalls of computerized analysis.
Audience: To whom the book is addressed is not quite clear,because the background necessary to read it varies from an undergraduate to a mature researcher.
Features: The book contains moderate amount of black-and-white photographs and schemes. Some of them are repeated in different chapters. The lists of references in some (not all) chapters are definitely outdated. In the chapter on transgenic animals, an important approach of regulated (inducible) mutations is only mentioned in a short note, though it was widely discussed already two years ago.
Assessment: This is a loose collection of chapters, some of which present the material in a concise and informative manner.
Alexander Kolchinsky
This book describes some basic methods of molecular studies in pathology of CNS disorders and gives selected examples of their application. All 11 chapters are written by different authors. The book is divided into two parts, the first on techniques and the second on their applications. All chapters are presented in different format with no apparent involvement of the editors. Part 1 contains a chapter on brain banks compiled in very general terms with no specific recommendations; a chapter on PCR with no specific reference to CNS, a chapter on RNA isolation with some useful notes; and chapters on in situ hybridization, immunocytochemistry, and autoradiography. Only one chapter contains an experimental protocol (immunostaining procedure). The second part of the book was intended to illustrate the application of the methods described in the first. Indeed, chapters on prion diseases and amyloidoses are fully relevant. The chapter on intracerebral transplantations, though quite informative, lies more on the physiological side. The chapter on transgenic animals belongs rather to the first part because of the complexity of the described methods and limited number of examples. The last chapter on quantitative imaging presents concise discussion of the potential advantages and pitfalls of computerized analysis. To whom the book is addressed is not quite clear,because the background necessary to read it varies from an undergraduate to a mature researcher. The book contains moderate amount of black-and-white photographs and schemes. Some of them are repeated in different chapters. The lists of references in some (not all) chapters are definitely outdated. In the chapter on transgenic animals, animportant approach of regulated (inducible) mutations is only mentioned in a short note, though it was widely discussed already two years ago. This is a loose collection of chapters, some of which present the material in a concise and informative manner.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780521425582
  • Publisher: Cambridge University Press
  • Publication date: 6/8/1995
  • Series: Postgraduate Medical Science Series
  • Edition number: 1
  • Pages: 190
  • Product dimensions: 5.98 (w) x 8.98 (h) x 0.43 (d)

Table of Contents

List of contributors
1 Brain banks 3
2 RNA isolation and analysis 10
3 Polymerase chain reaction 22
4 Principles and practice of in situ hybridization histochemistry in neuropsychiatric research 38
5 Immunocytochemistry: a neuropathological perspective 61
6 Autoradiography in brain research: theory, practice and applications 77
7 Human prion diseases 93
8 Molecular pathogenesis of the cerebral amyloidoses 109
9 Intracerebral transplantation and functional recovery 138
10 Methods of construction of transgenic animals and applications of the technology 156
11 Neuropathology by numbers: application of image analysis techniques to quantitative neuropathology 174
Index 185
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