Molecular Pathology: The Molecular Basis of Human Disease / Edition 1

Molecular Pathology: The Molecular Basis of Human Disease / Edition 1

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by William B. Coleman
     
 

Most "pathology" textbooks cover diseases and disease processes from the perspective of description (what does it look like and what are its characteristics), risk factors, disease-causing agents, and to some extent, cellular mechanisms. However, these books typically contain very sparse coverage (if any at all) of molecular mechanisms of disease. The reason for this…  See more details below

Overview

Most "pathology" textbooks cover diseases and disease processes from the perspective of description (what does it look like and what are its characteristics), risk factors, disease-causing agents, and to some extent, cellular mechanisms. However, these books typically contain very sparse coverage (if any at all) of molecular mechanisms of disease. The reason for this is partially historical - most major forms of disease have been known for a long time, but the molecular basis of these diseases are not always known or have been elucidated only recently. Nevertheless, our overall understanding of the molecular and genetic mechanisms of the pathogenesis of most major human diseases has been advancing at a significant pace over the last two decades. As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, there is a need for a new textbook where molecular mechanisms represent the focus. Molecular Pathology focuses on the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.

Molecular Pathology is appropriate as a classroom teaching tool for medical students, biomedical graduate students, and some allied health students. In addition, it should be used as a reference book for practicing basic scientists and physician scientists that perform disease-related research. Further, this textbook will be valuable for pathology residents and other postdoctoral fellows who need to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.


* Exam Master? web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
* Companion Web Site - would host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials
* Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
* Outlines the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology
* Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine

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Editorial Reviews

From the Publisher
"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."

—Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written toenhance thework of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order.Instead, the contributorsconcentrated on clarity of explanationsupported by selected examples so that the reader may grasp the fundamentals better.In fact, this may be one medical textbook thatcan be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."

—Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore

Product Details

ISBN-13:
9780080922195
Publisher:
Elsevier Science
Publication date:
02/10/2009
Series:
The Molecular Basis of Human Disease Series
Pages:
664

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Molecular Pathology: The Molecular Basis of Human Disease 5 out of 5 based on 0 ratings. 1 reviews.
Anonymous More than 1 year ago
This textbook is ideal for faculty teaching pathology courses in medical schools and graduate pathology, biomedical, and allied health departments. It teaches from the perspective of integrative systems biology and encompasses all molecular aspects of biology, as applied to the understanding of human diseases. If you are looking for an alternative textbook this is it as it provides state-of-the-art coverage of topics from cell injury and cell death, to the molecular basis of cardiovascular disease.