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Molecular Pathology: The Molecular Basis of Human Disease

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Overview

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

• Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
• Companion Web Site – will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials
• Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
• Outlines the principles and practice of molecular pathology
• Explains the practice of “molecular medicine” and the translational aspects of molecular pathology

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Editorial Reviews

From the Publisher
"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."

—Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written toenhance thework of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order.Instead, the contributorsconcentrated on clarity of explanationsupported by selected examples so that the reader may grasp the fundamentals better.In fact, this may be one medical textbook thatcan be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."

—Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore

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Product Details

  • ISBN-13: 9780123744197
  • Publisher: Elsevier Science
  • Publication date: 3/16/2009
  • Edition description: New Edition
  • Pages: 664
  • Product dimensions: 8.60 (w) x 11.00 (h) x 1.40 (d)

Meet the Author

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.

Gregory J. Tsongalis, Ph.D., H.C.L.D., C.C. is Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

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Table of Contents

PART I: Essential Pathology - Mechanisms of Disease
Molecular Mechanisms of Cell Death
Acute and Chronic Inflammation
Infection and Host Response
Neoplasia

PART II: Concepts in Molecular Biology and Genetics
Basic Concepts in Human Molecular Genetics
The Human Genome: Implications for the Understanding of Human Disease
The Human Transcriptome: Implications for the Understanding of Human Disease
The Human Epigenome: Implications for the Understanding of Human Disease
The Human Proteome: Implications for the Understanding of Human Disease
Integrative Systems Biology: Implications for the Understanding of Human Disease

PART III:Principles and Practice of Molecular Pathology
Pathology: The Clinical Description of Human Disease
Molecular Pathogenesis: The Biological Basis of Human Disease
Integration of Molecular and Cellular Pathogenesis

PART IV: Molecular Pathology of Human Disease
Molecular Basis of Cardiovascular Disease
Molecular Basis of Hemostatic and Thrombotic Diseases
Molecular Basis of Lymphoid and Myeloid Diseases
Molecular Basis of Diseases of Immunity
Molecular Basis of Pulmonary Disease
Molecular Basis of Diseases of the Gastrointestinal Tract
Molecular Basis of Liver Disease
Molecular Basis of Diseases of the Exocrine Pancreas
Molecular Basis of Diseases of the Endocrine System
Molecular Basis of Gynecologic Diseases
Molecular Basis of Prostate Disease
Molecular Basis of Breast Disease
Molecular Basis of Skin Disease
Molecular Basis of Diseases of the Nervous System

PART V: Practice of Molecular Medicine
Molecular Diagnosis of Human Disease
Molecular Assessment of Human Disease in the Clinical Laboratory
Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

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Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted June 15, 2009

    The only molecular pathology textbook that covers the molecular basis of major human diseases

    This textbook is ideal for faculty teaching pathology courses in medical schools and graduate pathology, biomedical, and allied health departments. It teaches from the perspective of integrative systems biology and encompasses all molecular aspects of biology, as applied to the understanding of human diseases. If you are looking for an alternative textbook this is it as it provides state-of-the-art coverage of topics from cell injury and cell death, to the molecular basis of cardiovascular disease.

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