Molecular Pharmacology

Overview

This text provides a brief introduction to general pharmacological principles and their use as experimental tools. By using receptor theory and molecular models, this text explores the mechanisms of drug responses in body systems without using the body itself. It also discusses biostatistics as related to drug-response quantification and optimization.

The book contains black-and-white illustrations.

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Overview

This text provides a brief introduction to general pharmacological principles and their use as experimental tools. By using receptor theory and molecular models, this text explores the mechanisms of drug responses in body systems without using the body itself. It also discusses biostatistics as related to drug-response quantification and optimization.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Thaddeus Marczynski, MD, PhD (University of Illinois at Chicago College of Medicine)
Description: This book describes measurements of drug activities in biological systems, assuming that these measurements may be useful for better understanding the mechanisms and therapeutic actions of drugs in humans. The book emphasizes operational approaches to quantifying molecular activity in organ systems; therefore, it does not require knowledge about detailed molecular mechanisms.
Purpose: The book is structured as an introduction to the science of pharmacology and application of its principles toward probing biological system, and as such the book is not targeted at any specific medical specialty.
Audience: The book is clearly useful to students as well to medical practitioners who want to understand the mechanisms of drug therapeutic actions and their potential untoward or toxic effects.
Features: Chapter 1 deals with definitions of major terms and classification of biological systems. Chapters 2 and 3 deal with the dose-response curves and their implications for modeling and understanding molecular events. Chapter 4 discusses human receptors created from recombinant DNA and their usefulness in clinical and basic research settings. Chapters 5 and 6 deal with estimates of drug tissue concentrations, receptor sensitivity and with various ways receptors transmit information to the cell. Chapters 7 and 8 are devoted to the methods used in evaluating receptor responses and antagonism of these responses, respectively. Chapter 9 deals with the statistical assessment of differences in biological system responses, as well as with their molecular interpretation.
Assessment: In general, the quality of the book is very good and should be purchased by libraries of medical colleges. Parenthetically, however, one should mention that figure 6-8A in its large title has a glaring misspelling error: "stimulis" instead of stimuli.
Thaddeus Marczynski
This book describes measurements of drug activities in biological systems, assuming that these measurements may be useful for better understanding the mechanisms and therapeutic actions of drugs in humans. The book emphasizes operational approaches to quantifying molecular activity in organ systems; therefore, it does not require knowledge about detailed molecular mechanisms. The book is structured as an introduction to the science of pharmacology and application of its principles toward probing biological system, and as such the book is not targeted at any specific medical specialty. The book is clearly useful to students as well to medical practitioners who want to understand the mechanisms of drug therapeutic actions and their potential untoward or toxic effects. Chapter 1 deals with definitions of major terms and classification of biological systems. Chapters 2 and 3 deal with the dose-response curves and their implications for modeling and understanding molecular events. Chapter 4 discusses human receptors created from recombinant DNA and their usefulness in clinical and basic research settings. Chapters 5 and 6 deal with estimates of drug tissue concentrations, receptor sensitivity and with various ways receptors transmit information to the cell. Chapters 7 and 8 are devoted to the methods used in evaluating receptor responses and antagonism of these responses, respectively. Chapter 9 deals with the statistical assessment of differences in biological system responses, as well as with their molecular interpretation. In general, the quality of the book is very good and should be purchased by libraries of medical colleges. Parenthetically, however, one should mention thatfigure 6-8A in its large title has a glaring misspelling error: ""stimulis"" instead of stimuli.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780865425408
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1997
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 256
  • Product dimensions: 7.99 (w) x 7.99 (h) x 0.26 (d)

Table of Contents

1 Biologic Systems and Definitions of Terms 1
2 Dose-Response Curves 22
3 Molecular Models of Drug-Receptor Interaction 43
4 Human Receptors from Recombinant DNA 64
5 Concentrations of Drugs in Tissues 92
6 Agonism and Stimulus-Response Mechanisms 114
7 Drug-Response Measurement Systems: Signal Strength, Stability, and Selectivity 143
8 Drug Antagonism 170
9 Statistical and Biologic Significance 201
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