Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters / Edition 1

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters / Edition 1

ISBN-10:
0792339134
ISBN-13:
9780792339137
Pub. Date:
08/31/1996
Publisher:
Springer Netherlands
ISBN-10:
0792339134
ISBN-13:
9780792339137
Pub. Date:
08/31/1996
Publisher:
Springer Netherlands
Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters / Edition 1

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters / Edition 1

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Overview

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Product Details

ISBN-13: 9780792339137
Publisher: Springer Netherlands
Publication date: 08/31/1996
Series: Developments in Cardiovascular Medicine , #182
Edition description: 1996
Pages: 602
Product dimensions: 8.27(w) x 10.98(h) x 0.39(d)

About the Author

Morad, M. (Georgetown Univ); Ebashi, S. (National Institute for Physiological Sciences, Okazaki, Japan); Trautwein, W. (Universitat des Saarlandes); Kurachi, Y. (Osaka Univ)

The contributors represent the specialties of physiology, pharmacology, neurophysiology, anatomy and cell biology, biophysics, and cardiovascular diseases. Most are from universities and research institutions in the U.S., Japan, the U.K., Canada, France, and Germany. Institutions prominently represented include Osaka Univ, UCLA, Univ of Maryland, and Universite de Paris-Sud.

Table of Contents

Preface. Thoughts of my Friend, Hiroshi Irisawa; S. Ebashi. Dr Hiroshi Irisawa during his Youth and Physiology; I. Seyama. Part One: Section I: Channels and Channel Proteins. 1. Introduction. 2. A Pacemaker Channel. 3. The Cardiac N+ Channel. 4. The L-Type Cardiac Ca2+ Channel. 5. The Cardiac K+ Channels. 6. Cardiac Cl- Channels. 7. Cardiac Ion Channels Not Gated by Voltage. Section II: Ion Channels in Cardiovascular Development. Section III: Pharmacology of Ion Channels. Section IV: Ion Channels and Cardiac Pathology. Part Two: Section One: Molecular Aspects of Ca2+ Release. Section II: Molecular Steps in Cardiac Relaxation. 2. Molecular Biology and Physiology of Na+-Ca2+ Exchange. 3. Contraction-Relaxation Regulation. Section III: Regulation of Celluar Ca2+ by Other Transporters. Index.
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