Molecular Physiology of Growth

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How do hormones and growth factors regulate animal growth in the developing embryo and after injury? What processes at the molecular level determine the growth patterns of different tissues? In this diverse synthesis of recent research, the regulation of growth in response to environmental and genetic stimuli is discussed at the level of the animal, tissues and cells. Contrasts are drawn between regulation in fetal and adult tissues, and in different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as hormones and growth factors. This state of the art review will be of significant interest to graduate students and research scientists in the fields of animal growth, endocrinology and cell biology.
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Editorial Reviews

From the Publisher
" excellent book of great cellular and molecular biology value." Cellular and Molecular Biology

"This book is a great resource for beginners as well as those who already use this technique, because each chapter contains its own methods section." James Konopka, The Quarterly Review of Biology

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Product Details

  • ISBN-13: 9780521471107
  • Publisher: Cambridge University Press
  • Publication date: 10/10/1996
  • Series: Society for Experimental Biology Seminar Series , #60
  • Edition description: New Edition
  • Pages: 182
  • Product dimensions: 5.98 (w) x 8.98 (h) x 0.59 (d)

Table of Contents

List of contributors
The role of growth hormone in growth regulation 1
Insulin-like growth factor-I and its binding proteins: role in post-natal growth 13
Growth factor interactions in epiphyseal chondrogenesis 35
Developmental changes in the CNS response to injury: growth factor and matrix interactions 49
The role of transforming growth factor [beta] during cardiovascular development 69
Tenascin: an extracellular matrix protein associated with bone growth 87
Compartmentation of protein synthesis, mRNA targeting and c-myc expression during muscle hypertrophy and growth 99
The role of mechanical tension in regulating muscle growth and phenotype 119
The pre-natal influence on post-natal muscle growth 135
Genomic imprinting and intrauterine growth retardation 151
Index 163
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