Molecular View Of A Beneficial T Cell Auto-Reactivity---Auto-Antigen Mediated Nkt Cell Activation.

Overview

The current dogma is that the immune system is meant to generate immune protection to pathogen and maintain tolerance to self. Auto-antigenic activation is mostly thought to be associated with auto-immune disease. NKT cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self antigens. Accumulated data suggest that auto-antigenic NKT cell activation is beneficial, however the mechanism remains poorly understood. We show here that auto-antigens serve as partial...
See more details below
Other sellers (Paperback)
  • All (2) from $72.22   
  • New (2) from $72.22   
Sending request ...

More About This Book

Overview

The current dogma is that the immune system is meant to generate immune protection to pathogen and maintain tolerance to self. Auto-antigenic activation is mostly thought to be associated with auto-immune disease. NKT cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self antigens. Accumulated data suggest that auto-antigenic NKT cell activation is beneficial, however the mechanism remains poorly understood. We show here that auto-antigens serve as partial agonists for NKT cells activating comparatively normal ERK signaling but deficient calcium signaling. Auto-antigenic activation leads NKT cells to a specialized activation status. In this activated status, NKT cell cytokine production is biased to IL-13 and GM-CSF, which correlates the high histone acetylation basal level on those gene loci in NKT cell population; NKT cells are less sensitive to subsequent strong glycolipid antigen alpha-GalCer stimulation; and NKT cells are reversibly primed to promptly respond to subsequent innate danger signals such as IL-12 combined with IL-18. These results show that instead of pathogenesis, auto-antigenic activation of NKT cells is an essential part of physiological NKT cell function.
Read More Show Less

Product Details

  • ISBN-13: 9781244572416
  • Publisher: BiblioLabsII
  • Publication date: 9/30/2011
  • Pages: 258
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.54 (d)

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)