Molecular Virology

Molecular Virology

by Alan J. Cann
     
 

ISBN-10: 012158531X

ISBN-13: 9780121585310

Pub. Date: 11/01/1993

Publisher: Elsevier Science & Technology Books

Provides an essential introduction to modern virology. Focussing on the new molecular approach, this textbook presents the principles of virology in a clear and concise manner that will give students of biology or medicine a broad, comprehensive understanding of the subject. The text explores and explains the fundamental aspects of virology including structure of…  See more details below

Overview

Provides an essential introduction to modern virology. Focussing on the new molecular approach, this textbook presents the principles of virology in a clear and concise manner that will give students of biology or medicine a broad, comprehensive understanding of the subject. The text explores and explains the fundamental aspects of virology including structure of virus particles and virus genomes, virus replication, control of gene expression, and virus pathogenesis (including AIDS). Later chapters consider the major current concerns in virology, such as responses to and treatment of virus infections, and the emergence of novel infectious agents including viruses, viroids and prions. The book is illustrated with over 100 clear line drawings, which complement the text. The summaries at the end of each chapter provide an excellent revision aid.

Product Details

ISBN-13:
9780121585310
Publisher:
Elsevier Science & Technology Books
Publication date:
11/01/1993
Edition description:
Older Edition
Pages:
200
Product dimensions:
6.68(w) x 9.59(h) x 0.54(d)

Table of Contents

Preface to the second edition
Preface to the first edition
Ch. 1Introduction1
Viruses are distinct from 'living' organisms1
The origins of virology3
Living host systems4
Cell culture methods6
Serological/immunological methods8
Ultrastructural studies11
'Molecular biology'16
Ch. 2Particles22
The function and formation of virus particles22
Capsid symmetry and virus architecture23
Enveloped viruses33
Complex structures37
Protein-nucleic acid interactions and genome packaging42
Virus receptors - recognition and binding46
Other interactions of the virus capsid with the host cell46
Ch. 3Genomes50
The structure and complexity of virus genomes50
Molecular genetics52
Virus genetics56
'Large' DNA genomes65
'Small' DNA genomes68
Positive-strand RNA viruses72
Negative-strand RNA viruses75
Segmented and multipartite virus genomes77
Reverse transcription and transposition81
Evolution and epidemiology91
Ch. 4Replication97
Overview of virus replication97
Investigation of virus replication98
The replication cycle102
Ch. 5Expression128
Expression of genetic information128
Control of prokaryote gene expression129
Control of expression in bacteriophage [lambda]130
Control of eukaryote gene expression134
Genome coding strategies136
Transcriptional control of expression146
Post-transcriptional control of expression151
Ch. 6Infection163
Virus infections of plants163
Immune responses to virus infections in animals166
Virus-host interactions175
The course of virus infections184
Prevention and therapy of virus infection187
Virus vectors and gene therapy190
Chemotherapy of virus infections192
Ch. 7Pathogenesis200
Mechanisms of cellular injury201
Viruses and immunodeficiency205
Virus-related diseases212
Cellular transformation by viruses214
Viruses and cancer225
New and emergent viruses228
Ch. 8Novel infectious agents: genomes without viruses, viruses without genomes239
Satellites and viroids239
Prions243
App. 1Classification of subcellular infectious agents259
App. 2: Glossary and abbreviations268
App. 3: Answers to self-assessment questions280
Index298

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