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Molecular Virology

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Overview

Provides an essential introduction to modern virology. Focussing on the new molecular approach, this textbook presents the principles of virology in a clear and concise manner that will give students of biology or medicine a broad, comprehensive understanding of the subject. The text explores and explains the fundamental aspects of virology including structure of virus particles and virus genomes, virus replication, control of gene expression, and virus pathogenesis (including AIDS). Later chapters consider the major current concerns in virology, such as responses to and treatment of virus infections, and the emergence of novel infectious agents including viruses, viroids and prions. The book is illustrated with over 100 clear line drawings, which complement the text. The summaries at the end of each chapter provide an excellent revision aid.

The book contains black-and-white illustrations.

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Editorial Reviews

Jerry Lynn Taylor
This second edition paperback book provides a broad introduction to virology. Although it is called Principles of Molecular Virology, the author also includes a broad-based introduction including a brief history of some early seminal works in the field. The author states that he designed the book to provide a text describing the general principles of "molecules and viruses" supplemented with specific examples for illustration purposes. He wanted it to reflect the current emphasis and concerns of virology. This book is not intended to be as encyclopedic as many virology texts, but rather to describe basic concepts in a very readable format and direct the reader to other works for greater detail. He has designed the text for teaching undergraduate student in virology. There is a remarkable amount of detail included for so small a book. This is accomplished through the use of many figures and much tabulated information. Although many of the figures are not self-explanatory, in combination with text material they provide much useful information. The text provides specific examples about bacteriophage, plant viruses, insect viruses, and mammalian viruses, as well as subviral particles, like pitons. This breadth of coverage sets the book apart from some other introductory virology texts that focus primarily on human viruses. Chapters are based on concepts, including pathogenesis, infection, and expression. Each chapter has self-assessment questions, which serve as a review of the chapter. There is also a very good glossary of terms. Terms whose definitions are found in the glossary are printed in bold in the text, triggering the reader to look up thedefinition. This well-written text provides a very useable introduction to virology. The information provided is current. It would be a worthwhile addition to the library of teachers of undergraduate virology.
From The Critics
Reviewer: Jerry Lynn Taylor, PhD (Medical College of Wisconsin)
Description: This second edition paperback book provides a broad introduction to virology. Although it is called Principles of Molecular Virology, the author also includes a broad-based introduction including a brief history of some early seminal works in the field.
Purpose: The author states that he designed the book to provide a text describing the general principles of "molecules and viruses" supplemented with specific examples for illustration purposes. He wanted it to reflect the current emphasis and concerns of virology.
Audience: This book is not intended to be as encyclopedic as many virology texts, but rather to describe basic concepts in a very readable format and direct the reader to other works for greater detail. He has designed the text for teaching undergraduate student in virology.
Features: There is a remarkable amount of detail included for so small a book. This is accomplished through the use of many figures and much tabulated information. Although many of the figures are not self-explanatory, in combination with text material they provide much useful information. The text provides specific examples about bacteriophage, plant viruses, insect viruses, and mammalian viruses, as well as subviral particles, like pitons. This breadth of coverage sets the book apart from some other introductory virology texts that focus primarily on human viruses. Chapters are based on concepts, including pathogenesis, infection, and expression. Each chapter has self-assessment questions, which serve as a review of the chapter. There is also a very good glossary of terms. Terms whose definitions are found in the glossary are printed in bold in the text, triggering the reader to look up the definition.
Assessment: This well-written text provides a very useable introduction to virology. The information provided is current. It would be a worthwhile addition to the library of teachers of undergraduate virology.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780121585310
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 11/1/1993
  • Edition description: Older Edition
  • Pages: 200
  • Product dimensions: 6.68 (w) x 9.59 (h) x 0.54 (d)

Table of Contents

Preface to the second edition
Preface to the first edition
Ch. 1 Introduction 1
Viruses are distinct from 'living' organisms 1
The origins of virology 3
Living host systems 4
Cell culture methods 6
Serological/immunological methods 8
Ultrastructural studies 11
'Molecular biology' 16
Ch. 2 Particles 22
The function and formation of virus particles 22
Capsid symmetry and virus architecture 23
Enveloped viruses 33
Complex structures 37
Protein-nucleic acid interactions and genome packaging 42
Virus receptors - recognition and binding 46
Other interactions of the virus capsid with the host cell 46
Ch. 3 Genomes 50
The structure and complexity of virus genomes 50
Molecular genetics 52
Virus genetics 56
'Large' DNA genomes 65
'Small' DNA genomes 68
Positive-strand RNA viruses 72
Negative-strand RNA viruses 75
Segmented and multipartite virus genomes 77
Reverse transcription and transposition 81
Evolution and epidemiology 91
Ch. 4 Replication 97
Overview of virus replication 97
Investigation of virus replication 98
The replication cycle 102
Ch. 5 Expression 128
Expression of genetic information 128
Control of prokaryote gene expression 129
Control of expression in bacteriophage [lambda] 130
Control of eukaryote gene expression 134
Genome coding strategies 136
Transcriptional control of expression 146
Post-transcriptional control of expression 151
Ch. 6 Infection 163
Virus infections of plants 163
Immune responses to virus infections in animals 166
Virus-host interactions 175
The course of virus infections 184
Prevention and therapy of virus infection 187
Virus vectors and gene therapy 190
Chemotherapy of virus infections 192
Ch. 7 Pathogenesis 200
Mechanisms of cellular injury 201
Viruses and immunodeficiency 205
Virus-related diseases 212
Cellular transformation by viruses 214
Viruses and cancer 225
New and emergent viruses 228
Ch. 8 Novel infectious agents: genomes without viruses, viruses without genomes 239
Satellites and viroids 239
Prions 243
App. 1 Classification of subcellular infectious agents 259
App. 2: Glossary and abbreviations 268
App. 3: Answers to self-assessment questions 280
Index 298
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