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Molecules and Medicine [NOOK Book]

Overview

Molecules And Medicine

This book is appropriate for a broad readership, starting with curious and thoughtful college undergraduates and reaching beyond to professors and researchers in the life sciences, chemistry, and medicine. This book provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine.

Molecules and Medicine delves into the discovery, application, and mode of action of more ...

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Molecules and Medicine

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Overview

Molecules And Medicine

This book is appropriate for a broad readership, starting with curious and thoughtful college undergraduates and reaching beyond to professors and researchers in the life sciences, chemistry, and medicine. This book provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine.

Molecules and Medicine delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now in use in modern medicine. Molecule structures and shapes are shown for all of these medicines. The opening sections of the book provide a unique, clear, and concise introduction which enables the reader to understand chemical formulas.

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Editorial Reviews

From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description: This is a picture book with explanations — various drugs are shown together with a superficial discussion of their application.
Purpose: The goal is to introduce molecules to the interested student. The hook is the medical utility of the representatives chosen, but the value of this is questionable and it is not clear that the goal is achieved.
Audience: The intended audience is undergraduate students with some passing interest in how drugs might work. Most lay readers could follow the text as well. One of the authors is a world class authority.
Features: This is basically a picture book of commonly used drugs, presenting structural and computer-derived space-filling formulas, divided into classes by their medical applications. In each target, some brief description of possible mode of action is provided. Some of the material is out of date and the choice of drugs seems entirely arbitrary (why lipitor, for example, as the only statin drug?). Statements like "Chemistry can cure disease," while true in some circumstances, are clearly hyperbole. References are provided for each of the compounds. A serious concern is that uninitiated readers (the target audience) will acquire a very superficial and possibly misleading set of facts about one or another commercial product. "A little learning is a dangerous thing," as Alexander Pope notably stated. Physics for poets may have its place, but science deserves better.
Assessment: This effort cannot be recommended since it is overly superficial.
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Product Details

  • ISBN-13: 9781118361733
  • Publisher: Wiley
  • Publication date: 2/28/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 272
  • File size: 25 MB
  • Note: This product may take a few minutes to download.

Meet the Author

E. J. Corey has been a Professor at Harvard University since 1959. He was educated at The Massachusetts Institute of Technology (1945-1950) and served as a faculty member at the University of Illinois from1951 to 1959. He is the 1990 Nobel Laureate in Chemistry, and the recipient of over seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal of the American Chemical Society. He is amember of the U.S. National Academy of Sciences and the U.S. National Institute of Medicine. Professor Corey is the author of more than 1,000 publications and is one of the most cited authors in science.

Barbara Czakó completed undergraduate studies at the University of Debrecen, Hungary, where she worked with Dr. Sándor Berényi. She obtained a Master of Science degree at the University of Missouri-Columbia with Professor Shon R. Pulley. Dr. Czakó received her Ph.D. degree (2006) in synthetic organic chemistry under the guidance of Professor Gary A. Molander at the University of Pennsylvania. Currently she is a postdoctoral fellow with Professor E.J. Corey at Harvard University. In 2005 she published with László Kürti the textbook Strategic Applications of Named Reactions in Organic Synthesis.

László Kürti was born and raised in Hungary. He received his diploma from the University of Debrecen, Hungary, where he conducted research in the laboratory of Professor Sándor Antus. Subsequently he received his Master of Science degree at the University of Missouri-Columbia working with Professor Michael Harmata, and his Ph.D. degree (2006) in synthetic organic chemistry under the supervision of Professor Amos B. Smith III (the University of Pennsylvania). Currently he is a Damon Runyon Cancer Fellow in the group of Professor E.J. Corey at Harvard University. In 2005 he published with Barbara Czakó the textbook Strategic Applications of Named Reactions in Organic Synthesis.

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Table of Contents

PART I. INTRODUCTION.

UNDERSTANDING STRUCTURAL DIAGRAMS OF ORGANIC MOLECULES.

SOME COMMON MOLECULES.

PROTEINS AND THREE-DIMENSIONAL PROTEIN STRUCTURE.

SOME OF THE PROTEIN STRUCTURES THAT APPEAR IN THIS BOOK.

PART II. INFLAMMATORY, CARDIOVASCULAR AND METABOLIC DISEASES.

ANTI-INFLAMMATORY AGENTS.

Acetylsalicylic acid Aspirin).

Naproxen (Aleve).

How Do Anti-Inflammatory Drugs Work?

Other Eicosanoids in Inflammation.

An Overview of Inflammation.

Celecoxib (Celebrex).

Prednisone (Deltasone).

Methotrexate (Trexall).

Allopurinol (Zyloprim).

ANTIASTHMATIC AND ANTIALLERGIC AGENTS.

Salmeterol (Serevent).

Fluticasone Propionate (Flovent).

Montelukast Sodium (Singulair).

Tiotropium Bromide (Spiriva).

Loratadine (Claritin).

TYPE 2 DIABETES.

An Overview of Metabolic Syndrome.

ANTIDIABETIC AND CHOLESTEROL-LOWERING AGENTS.

Metformin (Glucophage).

Glipizide (Glucotrol).

Pioglitazone (Actos).

Sitagliptin (Januvia).

Atorvastatin (Lipitor).

Ezetimibe (Zetia).

CARDIOVASCULAR AGENTS.

Atenolol (Tenormin).

Enalapril (Vasotec).

Candesartan Cilexetil (Atacand).

Aliskiren (Tekturna).

Amlodipine (Norvasc).

Nitroglycerin.

Clopidogrel Bisulfate (Plavix).

Digoxin (Lanoxin).

RECEPTORS AND SIGNALING.

Information Flow into the Cell by Chemical Signaling.

REFERENCES FOR PART II.

PART III. REPRODUCTIVE MEDICINE.

Oral Contraceptives.

Testosterone.

Mifepristone (Mifeprex).

Oxytocin (Oxytocin).

Sildenafil (Viagra).

OSTEOPOROSIS.

Some Aspects of Osteoporosis.

Alendronate (Fosamax).

Calcitriol (Rocaltrol).

Raloxifene (Evista).

Teriparatide (Forteo).

GLAUCOMA AND ANTIULCER AGENTS.

Latanoprost (Xalatan).

Ranitidine (Zantac).

Omeprazole (Prilosec).

REFERENCES FOR PART III.

PART IV. AUTOIMMUNE DISEASE AND ORGAN TRANSPLANT.

A Brief Survey of the Immune System.

IMMUNOSUPPRESSIVE AGENTS.

Azathioprine (Imuran).

Mycophenolate Mofetil (CellCept).

Cyclosporin (Neoral).

Tacrolimus (Prograf).

FTY720 (Fingolimod).

INFECTIOUS DISEASES.

ANTIBIOTICS.

Amoxicillin (Amoxil).

Cefaclor (Ceclor).

Doxycycline (Vibramycin).

Azithromycin (Zithromax).

Ciprofloxacin (Cipro).

Trimethoprim (Triprim).

Amikacin (Amikin).

Vancomycin (Vancocin).

Linezolid (Zyvox).

Isoniazid (Laniazid).

Ancillary Antibiotics.

Drug Resistance.

ANTIVIRAL AGENTS.

On Viruses and Viral Diseases.

Acyclovir (Zovirax).

Ribavirin (Virazole).

Oseltamivir (Tamiflu).

Zidovudine (Retrovir, AZT).

Zalcitabine (Hivid).

Nevirapine (Viramune).

Efavirenz (Sustiva).

Lopinavir + Ritonavir (Kaletra).

UK427857 (Maraviroc).

ANTIFUNGAL AGENTS.

Amphotericin (Fungizone).

Fluconazole (Diflucan).

Caspofungin (Cancidas).

Terbinafine (Lamisil).

ANTIMALARIAL AND ANTIPARASITIC AGENTS.

Parasitic Diseases: A Focus on Malaria.

Chloroquine (Aralen).

Artemether + Lumefantrine (CoArtem).

Atovaquone + Proguanil (Malarone).

Miltefosine (Impavido).

Nitazoxanide (Alinia).

Ivermectin (Stromectol).

REFERENCES FOR PART IV.

PART V. MALIGNANT DISEASE.

An Overview of Cancer.

Capecitabine (Xeloda).

Carboplatin (Paraplatin).

Vinblastine (Velban).

Paclitaxel (Taxol).

Cyclophosphamide (Cytoxan).

Tamoxifen (Nolvadex).

Irinotecan (Camptosar).

Bleomycin (Blenoxane).

Imatinib (Gleevec).

Sunitinib (Sutent).

Bortezomib (Velcade).

Ancillary Anticancer Agents.

REFERENCES FOR PART V.

PART VI. DRUGS ACTING ON THE NERVOUS SYSTEM.

PAIN AND ANALGESIA.

Lidocaine (Xylocaine).

Morphine (Avinza).

Acetaminophen (Tylenol).

Fentanyl (Duragesic).

Sodium Thiopental (Sodium Pentothal).

Gabapentin (Neurontin).

Diazepam (Valium).

Sumatriptan (Imitrex).

HYPNOTICS (INSOMNIA) AND ANTISMOKING.

Zolpidem (Ambien).

Ramelteon (Rozerem).

Varenicline (Chantix).

The Brain, Neurotransmission and Molecular Neurotransmitters.

NEURODEGENERATIVE AND PSYCHIATRIC DISEASES.

Levodopa (Larodopa).

Donepezil (Aricept).

ANTIEPILEPTIC AGENTS.

ANTIANXIETY AGENTS.

ANTIDEPRESSANTS.

ANTIPSYCHOTICS.

REFERENCES FOR PART VI.

GLOSSARY.

INDEX.

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Customer Reviews

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Sort by: Showing all of 4 Customer Reviews
  • Anonymous

    Posted May 27, 2012

    Good!!!

    Very good explanation clear and even though its a bit technacal at times otherwise its perfect!!! 500 stars!!!!

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  • Anonymous

    Posted October 21, 2007

    Chemistry leads medicine

    The thoughtful presentation of what drugs can and can not do in medicine. This analysis is based om the chemical structure of the drug and the known mechanisms of the drug's action. It is a text not unlike Richard Courant's What is Mathematics useful to the beginning student as well as a professor of science and medicine. It may serve well an enlightened layman and a physician in practise.

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  • Anonymous

    Posted April 17, 2010

    No text was provided for this review.

  • Anonymous

    Posted March 20, 2010

    No text was provided for this review.

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