Monoamine Oxidase Inhibitors in Neurological Diseases / Edition 1

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Emphasizing the role of monoamine oxidase (MAO) in the etiology and pathogenesis of Parkinson's disease and Alzheimer's disease, this up-to-date reference describes the genetics, physiology, biochemistry, pharmacology, and clinical aspects of this very important class of enzymes.

Details how the interaction between selegiline (deprenyl) and MAO may retard the progression of neurodegenerative disorders!

Providing the latest theories on how selegiline operates, Monoamine Oxidase Inhibitors in Neurological Diseases

  • presents fundamental information on MAO types A and B
  • examines the distribution of MAO A and B in the normal human brain
  • investigates the effects of disease and aging on MAO A and B
  • analyzes a critical role for MAO in the toxic action in Parkinson's disease
  • elucidates selegiline's novel ability to delay the progression or repair the damage of dopaminergic neurons
  • discusses the usefulness of MAO inhibitors in psychiatric disease
  • and more!

This book contains black-and-white illustrations.

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Editorial Reviews

A cross-section of the controversy over why selegiline (deprenyl, Eldepryl), a specific monoamine oxidase type B inhibitor, seems to slow the progress of neurological diseases such as Parkinson's, Huntington's, and Alzheimer's. Some say the findings indicate that the diseases have a largely environmental etiology; others stick to their genetic guns. Among the topics are the structure, molecular genetics, organization and inheritance of monoamine oxidases A and B; the reduction of nerve cell death by deprenyl without monoamine oxidase inhibition; and the inhibitors as neuroprotective therapy. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780824790820
  • Publisher: Taylor & Francis
  • Publication date: 1/12/1994
  • Series: Neurological Disease and Therapy Series, #21
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 400
  • Product dimensions: 6.25 (w) x 9.25 (h) x 0.25 (d)

Table of Contents

The Distribution of Monoamine Oxidases A and B in Normal Human Brain, Karin N. Westlund
Effects of Disease and Aging on Monoamine Oxidases A and B, Manfred Gerlach, Peter Riederer, and Moussa B. H. Youdim
Biochemistry and Mechanism of Action of Monoamine Oxidases A and B, Eimear M. O'Brien and Keith F. Tipton
The Structure, Gene, and Promoter Organization of Monoamine Oxidases A and B, Jean Chen Shih, Kevin Chen, Joseph S. Grimsby, Qin-Shi Zhu, and Timothy K. Gallaher
Molecular Genetics and Inheritance of Human Monoamine Oxidases A and B, Xandra O. Breakefield, Zheng-Yi Chen, Elizabeth Tivol, Christo Shalish, and Ian W. Craig
Role of Monoamine Oxidase Genetics in the Etiology of Parkinson's Disease, Janice H. Kurth and Matthias C. Kurth
Multiple Forms of Monoamine Oxidase and Iron: Their Relevance to the Pathology and Treatment of Parkinson's Disease, Moussa B. H. Youdim, Dorit Ben-Shachar, and Peter Riederer
A Critical Role for Monoamine Oxidase in Toxin Action in Parkinson's Disease, Peter Jenner
Effects of Monoamine Oxidase B Inhibitors on Dopaminergic Function: Role of 2-Phenylethylamine and Aromatic L-Amino Acid Decarboxylase, Augusto V. Juorio, Xin-Min Li, I. A. Paterson, and Alan A. Boulton
Inhibition of Monoamine Oxidase B and the Neuroprotective Effects of Selegiline, Kevin T. Finnegan
Reduction of Nerve Cell Death by Deprenyl Without Monoamine Oxidase Inhibition, William G. Tatton, Nadine A. Seniuk, William Y. H. Ju, and Karen S. Ansari
Monoamine Oxidase Inhibitors as Neuroprotective Therapy, Warren Olanow and Donald B. Calne
Selegiline as Symptomatic Treatment for Parkinson's Disease, Abraham Lieberman
Monoamine Oxidase Inhibitors in Alzheimer's Disease, Jody Corey-Bloom and Leon J. Thal
Role of Monoamine Oxidase Inhibitors in Psychiatry, David J. Houlihan and Samuel Gershon

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