Motor Neuron Disease, An Issue of Physical Medicine and Rehabilitation Clinics

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Overview

Half a century ago Lou Gehrig was given his diagnosis: amyotrophic lateral sclerosis. It remains a devastating terminal disease. However, considerable effort has been made in the last decade by some of the premier neurologists, physiatrists, and neuroscientists in the world to elucidate a greater understanding of pathogenic mechanisms, to characterize the disease clinically, and to find greater ways to ease suffering for these patients. In this issue of Physical Medicine and Rehabilitation Clinics of North America, we have brought together some of the world’s leading authorities on amyotrophic lateral sclerosis and other motor neuron diseases to emphasize this ongoing research and to explain what the future holds in regard to our further understanding of these diseases.

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Product Details

  • ISBN-13: 9781416063377
  • Publisher: Elsevier Health Sciences
  • Publication date: 8/11/2008
  • Series: Clinics: Internal Medicine Series
  • Pages: 429
  • Product dimensions: 6.20 (w) x 9.10 (h) x 0.70 (d)

Table of Contents

Foreword George H. Kraft xv

Preface Michael D. Weiss Gregory T. Carter xix

Dedication Michael D. Weiss Gregory T. Carter xxi

Genetics of Amyotrophic Lateral Sclerosis Nailah Siddique Teepu Siddique 429

Glial Cells in ALS: The Missing Link? Elsa Raibon Lisa Marie Todd Thomas Moller 441

Current and Future Directions in Genomics of Amyotrophic Lateral Sclerosis John Ravits Bryan J. Traynor 461

Androgen Receptor Function in Motor Neuron Survival and Degeneration Gregory A. Cary Albert R. La Spada 479

Designing Clinical Trials in Amyotrophic Lateral Sclerosis Jeremy M. Shefner 495

Motor Unit Number Estimation in the Assessment of Performance and Function in Motor Neuron Disease Mark B. Bromberg Alexander A. Brownell 509

Fatigue in Amyotrophic Lateral Sclerosis Jau-Shin Lou 533

The Role of Exercise in Amyotrophic Lateral Sclerosis Amy Chen Jacqueline Montes Hiroshi Mitsumoto 545

Respiratory Treatment of Amyotrophic Lateral Sclerosis Joshua O. Benditt Louis Boitano 559

Nutrition and Dietary Supplements in Motor Neuron Disease Jeffrey Rosenfeld Amy Ellis 573

Quality of Life in Amyotrophic Lateral Sclerosis Mark B. Bromberg 591

Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis Susan C. Woolley Jonathan S. Katz 607

The Amyotrophic Lateral Sclerosis Center: A Model of Multidisciplinary Management Angeli S. Mayadev Michael D. Weiss B. Jane Distad Lisa S. Krivickas Gregory T. Carter 619

Drug Therapy in Amyotrophic Lateral Sclerosis B. Jane Distad Gregg D. Meekins Lee L. Liou Michael D. Weiss Gregory T. Carter Robert G. Miller 633

Clinical Trials in Spinal Muscular Atrophy Petra Kaufmann Susan T. Iannaccone 653

Diagnosis and ClinicalManagement of Spinal Muscular Atrophy Jay J. Han Craig M. McDonald 661

Index 681

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