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Mouse Genetics : Concepts and Applications / Edition 1
     

Mouse Genetics : Concepts and Applications / Edition 1

by Lee M. Silver, Silver
 

ISBN-10: 0195075544

ISBN-13: 9780195075540

Pub. Date: 01/28/1995

Publisher: Oxford University Press, USA

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the

Overview

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

Product Details

ISBN-13:
9780195075540
Publisher:
Oxford University Press, USA
Publication date:
01/28/1995
Pages:
376
Product dimensions:
9.50(w) x 6.38(h) x 1.02(d)

Table of Contents

1. An Introduction to Mice
1.1. Of Mice, Men, and a Woman
1.2. The Origin of Mice in Genetic Research
1.3. The New Biology and the Mouse Model
2. Town Mouse, Country Mouse
2.1. What are Mice?
2.2. Where Do Mice Come From?
2.3. The Mus Species Group and the House Mouse
2.4. Lifestyles and Adaptability of Wild House Mice
3. Laboratory Mice
3.1. Sources of Laboratory Mice
3.2. Mouse Crosses and Standard Strains
3.3. Coisogenics, Congenics, and Other Specialized Strains
3.4. Standardized Nomenclature
3.5. Strategies for Record-Keeping
4. Reproduction and Breeding
4.1. Reproductive Performance: Comparison of Inbred Strains
4.2. Germ Cell Differentiation and Sexual Maturation
4.3. Mating and Pregnancy
4.4. The Postnatal Period
4.5. Assisted Reproduction for the Infertile Cross
5. The Mouse Genome
5.1. Quantifying the Genome
5.2. Chromosomes
5.3. Genome Evolution and Gene Families
5.4. Repetitive "Non-Functional" DNA Families
5.5. Genomic Imprinting
6. Mutagenesis and Transgenesis
6.1. Classical Mutagenesis
6.2. Embryo Manipulation
6.3. Transgenic Mice Formed by Nuclear Injection
6.4. Targeted Mutagenesis and Gene Replacement
6.5. Further Uses of Transgenic Technologies
7. Mapping in the Mouse: An Overview
7.1. Genetic Maps Come in Various Forms
7.2. Mendel's Genetics, Linkage, and the Mouse
7.3. General Strategies for Mapping Mouse Loci
7.4. The Final Chapter of Genetics
8. Genetic Markers
8.1. Genotypic and Phenotypic Variation
8.2. Restriction Fragment Length Polymorphisms (RFLPs)
8.3. Polymorphisms Detected by PCR
8.4. Region-Specific Panels of DNA Markers
9. Classical Linkage Analysis and Mapping Panels
9.1. Demonstration of Linkage in the Mouse
9.2. Recombinant Inbred Strains
9.3. Interspecific Mapping Panels
9.4. Starting From Scratch With a New Mapping Project
9.5. Quantitative Traits and Polygenic Analysis
10. Non-Breeding Mapping Strategies
10.1. Linkage Maps Without Breeding
10.2. Chromosomal Mapping Tools
10.3. Physical Maps and Positional Cloning
10.4. The Human Genome Project and the Ultimate Map
Appendix A: Suppliers of Mice.
Appendix B: Computational Tools and Electronic Databases.
Appendix C: Source Materials for Further Reading.
Appendix D: Statistics.
Appendix E: Glossary of Terms.

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