Mouse Genetics : Concepts and Applications / Edition 1

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Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

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Product Details

  • ISBN-13: 9780195075540
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/1995
  • Edition number: 1
  • Pages: 376
  • Product dimensions: 9.50 (w) x 6.38 (h) x 1.02 (d)

Meet the Author

Princeton University
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Table of Contents

1 An Introduction to Mice 3
2 Town Mouse, Country Mouse 15
3 Laboratory Mice 32
4 Reproduction and Breeding 62
5 The Mouse Genome 76
6 Mutagenesis and Transgenesis 114
7 Mapping in the Mouse: An Overview 133
8 Genetic Markers 159
9 Classical Linkage Analysis and Mapping Panels 195
10 Non-breeding Mapping Strategies 264
Appendix A: Suppliers of Mice 285
Appendix B: Computational Tools and Electronic Databases 286
Appendix C: Source Materials for Further Reading 291
Appendix D: Statistics 294
Appendix E: Glossary of Terms 307
Notes 317
References 327
Index 353
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