Mouse Models in the Study of Genetic Neurological Disorders / Edition 1

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Overview

This volume covers the use of animal models for human genetic disease, including models of developmental disorders, neuromuscular diseases, neurodegenerative diseases and learning disorders. Researchers who study these disorders will find this volume a useful resource.

Disc. specific diseases, incl. x-linked demyelination, ALS, Charcot-Marie-Tooth disease & Down's; developmental errors.

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Editorial Reviews

Booknews
With a hapless transgenic mouse expressing a human spinocerebellular ataxia type I gene on the cover, this volume comprises 14 contributed chapters by 31 international specialists in the neurosciences. The editor concedes that, with the rapid proliferation of mouse models for neurological disorders, this can hardly be a comprehensive compendium. Following his overview of such genetically engineered models in neuroscience research, coverage treats models in the study of: Pelizaeus-Merzbacher disease, Charcot-Marie Tooth disease, cerebellar development, the role of neurotrophic factors in development and neurodegenerative disorders, neurofilament abnormalities, amyotrophic lateral sclerosis, CAG trinucleotide repeat diseases, Alzheimer's, lysomal disorders, PKU/hyperphenylalaninemia, Down syndrome, and epilepsy. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780306459658
  • Publisher: Springer US
  • Publication date: 2/28/1999
  • Series: Advances in Neurochemistry Series , #9
  • Edition description: 1999
  • Edition number: 1
  • Pages: 366
  • Product dimensions: 6.30 (w) x 9.20 (h) x 1.20 (d)

Table of Contents

1. An Overview of Mouse Models in Neuroscience Research; B. Popko. 2. X-Linked Dysmyelination: Mouse Models of Pelizaeus-Merzbacher Disease; K.-A. Nave. 3. Charcot-Marie-Tooth Disease: Pathology, Genetics and Animal Models; U. Suter. 4. Mouse Mutations in the Study of Cerebellar Development; D. Karagogeos, O. Pavlou . 5. The Role of Neurotrophic Factors in Development and Neurodegenerative Disorder; W.D. Snider, I. Silos-Santiago. 6. Transgenic Mice with Neurofilament Abnormalities; C. Lampron, et al. 7. Mouse Models of Amyotrophic Lateral Sclerosis; T.L. Williamson, D.W. Cleveland. 8. Transgenic Mouse Models of CAG Trinucleotide Repeat Neurologic Diseases; H.T. Orr, H.Y. Zoghbi. 9. Alzheimer's Disease and Genetically Engineered Animal Models; D.R. Borchelt, et al. 10. Model of Genetic Susceptibility to Late-Onset Alzheimer's Disease: Mice Transgenic for Human Apolipoprotein E Alleles; D.E. Schmechel, et al. 11. Lysosomal Disorders; K. Suzuki, et al. 12. Neurological Implications of the Genetic Mouse Modesl Human Phenylketonuria and Hyperphenylalinemia; J.D. McDonald. 13. Mouse Models of Down Syndrome; M.T. Davisson, A.C. Costa. 14. Modeling Epileptic Disorders in Mice; T.N. Seyfried, et al.

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